Elderly Black man receiving the COVID vaccine at West Philly community vaccine clinic

At Penn Medicine, we are administering the COVID-19 vaccines in the fairest, safest and quickest way possible.

If you would like more information about the vaccines or to schedule a vaccine appointment, please call our COVID-19 Vaccine Scheduling Hotline between 8 am and 5 pm, Monday through Friday, at 267-758-4902.

If you would like us to keep you updated about the COVID vaccines at Penn Medicine, please complete our Vaccine Interest Form for PA residents and for NJ residents visit NJVSS

COVID-19 Vaccine Boosters

Penn Medicine is providing booster shots of the Pfizer-BioNTech, Moderna and Johnson & Johnson COVID-19 vaccines to these groups:

  • Members of our own healthcare workforce
  • Patients ages 16 and older who are severely immunocompromised* and received their second dose of Pfizer at least 28 days ago
  • Patients ages 18 and older who are severely immunocompromised* and received their second dose of Moderna at least 28 days ago
  • Patients ages 18 and older who received their second dose of Pfizer at least six months ago
  • Patients ages 18 and older who received their second dose of Moderna at least six months ago
  • Patients ages 18 and older who received their dose of Johnson & Johnson at least two months ago

CDC guidance allows eligible individuals to choose which vaccine they receive as a booster dose. Some people may prefer to receive the same vaccine type that they originally received, and others may prefer to get a different vaccine booster. If you are not sure which vaccine to get as your booster dose, you should speak with your health care provider.

We encourage anyone who is eligible for a booster to go their local pharmacy due to our limited capacity to provide boosters. Unlike last winter, there is ample supply of vaccine in the community, including at retail pharmacies close to your home. We remain confident in our area pharmacies’ ability to provide your COVID booster shots, safely and conveniently, just like they do with flu shots every year.

We will continue to provide first and second shots to those who are unvaccinated.

*Information for Immunocompromised Patients

People with weakened immune systems have a harder time fighting infections and are especially vulnerable to viruses like COVID. The FDA authorized an additional dose of the Pfizer and Moderna COVID-19 vaccines for people whose immune systems are severely weakened, meaning they:

  • Are currently receiving active treatment with chemotherapy or daily radiation therapy for cancer (such as lung cancer, breast cancer and/or cancer of the blood (leukemia or lymphoma))
  • Are the recipient of an organ transplant and taking immunosuppressive therapy to prevent organ rejection, or are currently being treated for graft versus host disease after transplant
  • Have undergone CAR-T-cell or had a stem cell transplant within the last 2 years and currently taking immunosuppression therapy
  • Are diagnosed with moderate or severe primary immunodeficiency (e.g., DiGeorge syndrome, Wiskott-Aldrich syndrome, Severe Combined Primary Immunodeficiency, Chronic Granulomatous Disease, Common Variable Immunodeficiency, Congenital Neutropenia Syndrome, X-Linked Lymphoproliferative Disease, X-Linked Agammaglobulinemia, and others)
  • Have advanced or untreated HIV infection with a CD4 cell count less than 200 cells
  • Are currently taking one or more of the following medications in doses at or above what is listed:
    • Prednisone 20 mg. daily or more for 2 or more weeks
    • Dexamethasone 3 mg. daily
    • Methylprednisolone 16 mg daily
    • Hydrocortisone 80mg daily
    • Methotrexate (e.g., Otresup, Rasuvor, Rheumatrex or Trexall) 0.4 mg/kg/week or more
    • Azathioprine (e.g., Azasan or Imuran) 3 mg/kg/day or more
    • 6-mercaptopurine (e.g., Purinethol or Purixan) 1.5 mg/kg/day or more
    • Rituximab (e.g. Rituxan, Truxima, Ruxience, or Riabni)
    • Nataluzimab (e.g. Tysabri)
    • Alemtuzumab (e.g. Lemtrada)
    • Eculizumab (e.g., Soliris)

People with severely weakened immune systems should receive the additional dose at least 28 days following the two-dose regimen of the same vaccine .

If you make an appointment and come to a Penn Medicine location for your third dose, you will need to confirm that you have one of the conditions listed above. You are welcome to schedule at a location outside of Penn Medicine. Please let us know if you receive an additional dose outside of Penn, so we can update your medical record.

Vaccine Locations at Penn Medicine

Where Adults Can Get the COVID Vaccines

The Pfizer-BioNTech vaccine is fully approved by the FDA for adults ages 16 years and older. The FDA has authorized the emergency use of the Moderna and Johnson & Johnson vaccines for adults 18 years of age and older. We recommend that anyone who is eligible gets vaccinated to protect yourself and others from COVID.

To schedule a vaccine appointment at one of the Penn Medicine locations listed below, please call our COVID-19 Vaccine Scheduling Hotline at 267-758-4902. We answer calls between 8 am and 5 pm on Monday through Friday. We also have walk-in hours (where appointments are not necessary) at some of our vaccine clinics. 

Penn Medicine Chester County Hospital

701 E Marshall St, West Chester, PA 19380

Please visit the Chester County Hospital website for more information and updates.

Penn Medicine Lancaster General Health

555 N Duke St, Lancaster, PA 17602

Please visit the Lancaster General Health website for more information on how to schedule an appointment.

Penn Medicine Princeton Health

1 Plainsboro Rd, Plainsboro Township, NJ 08536

Please visit the Princeton Health website for more information and updates. 

Penn Medicine Valley Forge 

1001 Chesterbrook Blvd, Berwyn, PA 19312

By Appointment Only

Pennsylvania Hospital, Hall Mercer Building

245 S. 8th Street, Philadelphia, PA 19107

Walk-ins welcome: Thursday and Friday, 8:30 am - 11:15 am and 12:15 pm - 3:00 pm

Penn Presbyterian Medical Center

51 N. 39th Street, Philadelphia, PA, 19104 - 1st floor lobby, Wright Saunders Building

Walk-ins welcome: Wednesday and Friday, 8:30 am - 3:30 pm

Perelman Center for Advance Medicine

3400 Civic Center Boulevard, Philadelphia, PA 19104 - 15th floor - South Pavilion

By Appointment Only

The Theater of the Living Arts (TLA)

This location is now closed. We moved the clinic to the Hall Mercer Building at Pennsylvania Hospital

Where Children and Adolescents Can Get the Pfizer COVID Vaccine

The FDA has authorized the emergency use authorization for the Pfizer-BioNTech COVID-19 vaccine to children 5 through 11 years old and adolescents 12 through 15 years old.

For children ages 5 to 11, we are planning to make the Pfizer/BioNTech vaccine available in the coming weeks at certain family medicine practices and at future community clinics. We encourage parents to take advantage of vaccine information and availability through their local pharmacy, their child’s pediatrician and other community vaccination events as well.

Currently, we are offering the Pfizer vaccine to adolescents 12 to 15 years old in the following Penn Medicine locations.

Please note: Those under 18 must be accompanied by a parent or legal guardian.

Penn Medicine Chester County Hospital

To schedule, call the vaccine scheduling hotline at 267-758-4902.

Penn Medicine Lancaster General Health

For more information, please visit the Lancaster General Health website

Penn Medicine Princeton Health

Register with the New Jersey Vaccine Scheduling System (NJVSS) online and select "Penn Medicine Princeton Medical Center".

Children's Hospital of Philadelphia (CHOP)

For more information, please visit the CHOP website

Who Should Get the COVID Vaccine


If you have any questions about a COVID vaccine and whether you should receive it, please contact your health care provider.

We recommend that you speak with your doctor before receiving the vaccines if you have any of the following conditions:

  • A history of severe allergic reactions or anaphylactic reaction to a medication or vaccine
  • A bleeding disorder
  • Are taking a blood thinner
  • Are immunocompromised
  • Are taking a medicine that affects your immune system
  • Are pregnant or plan to become pregnant
  • Are breastfeeding

Have questions about the COVID-19 vaccines?

Check out our frequently asked questions (FAQs) for more information on vaccine safety, getting vaccinated and booster shots.

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