Elderly Black man receiving the COVID vaccine at West Philly community vaccine clinic

At Penn Medicine, we are administering the COVID-19 vaccines in the fairest, safest and quickest way possible. Our ultimate goal is to ensure that everyone who wants a vaccine gets it.

If you would like more information about the vaccines or to schedule a vaccine appointment, please call our COVID-19 Vaccine Scheduling Hotline between 8 am and 5 pm, Monday through Friday, at 267-758-4902.

If you would like us to keep you updated about the COVID vaccines at Penn Medicine, please complete our Vaccine Interest Form for PA residents and for NJ residents visit NJVSS.

Information on Moderna and Johnson & Johnson Boosters

Penn Medicine is working on plans to begin offering booster shots of the Moderna and Johnson & Johnson COVID-19 vaccines beginning the week of October 25, 2021. Please check back on that date for more information.

COVID-19 Vaccine Boosters

Information on Pfizer Vaccine Boosters

Penn Medicine is providing booster shots of the Pfizer-BioNTech COVID-19 vaccine initially to two groups:

  • Members of our own healthcare workforce who received their second dose of Pfizer at least six months ago
  • Patients ages 65 and older who received their second dose of Pfizer at least six months ago

We also encourage anyone who is eligible for a boosterincluding people between 18 and 64 years of age who have underlying medical conditions and people whose jobs put them at a high risk of exposureto go their local pharmacy to get their booster shots due to our limited capacity to provide boosters. Unlike last winter, there is now ample supply of vaccine in the community, including at retail pharmacies close to your home. We remain confident in our area pharmacies’ ability to provide your COVID booster shots, safely and conveniently, just like they do with flu shots every year.

We will continue to provide third shots to patients who are immunocompromised and first and second shots to those who are unvaccinated. (Please see below for more information for immuncompromised patients.)

The FDA and CDC are expected to conduct meetings in the future to determine whether people who received the two-dose Moderna vaccine or the single-dose Johnson & Johnson vaccine also need a booster. At this time, only patients who received the two-dose Pfizer vaccine may be eligible for a booster.  

Information for Immunocompromised Patients

The FDA authorized an additional dose of the Pfizer-BioNTech and Moderna COVID-19 vaccines for for people whose immune systems are severely weakened. This includes people who:

  • Are currently receiving active treatment with chemotherapy or daily radiation therapy for cancer (such as lung cancer, breast cancer and/or cancer of the blood (leukemia or lymphoma))
  • Are the recipient of an organ transplant and taking immunosuppressive therapy to prevent organ rejection, or are currently being treated for graft versus host disease after transplant
  • Have undergone CAR-T-cell or had a stem cell transplant within the last 2 years and currently taking immunosuppression therapy
  • Are diagnosed with moderate or severe primary immunodeficiency (e.g., DiGeorge syndrome, Wiskott-Aldrich syndrome, Severe Combined Primary Immunodeficiency, Chronic Granulomatous Disease, Common Variable Immunodeficiency, Congenital Neutropenia Syndrome, X-Linked Lymphoproliferative Disease, X-Linked Agammaglobulinemia, and others)
  • Have advanced or untreated HIV infection with a CD4 cell count less than 200 cells
  • Are currently taking one or more of the following medications in doses at or above what is listed:
    • Prednisone 20 mg. daily or more for 2 or more weeks
    • Dexamethasone 3 mg. daily
    • Methylprednisolone 16 mg daily
    • Hydrocortisone 80mg daily
    • Methotrexate (e.g., Otresup, Rasuvor, Rheumatrex or Trexall) 0.4 mg/kg/week or more
    • Azathioprine (e.g., Azasan or Imuran) 3 mg/kg/day or more
    • 6-mercaptopurine (e.g., Purinethol or Purixan) 1.5 mg/kg/day or more
    • Rituximab (e.g. Rituxan, Truxima, Ruxience, or Riabni)
    • Nataluzimab (e.g. Tysabri)
    • Alemtuzumab (e.g. Lemtrada)
    • Eculizumab (e.g., Soliris)

We are scheduling third vaccine dose appointments for severely immunocompromised patients at Penn Medicine. When you arrive at your third dose appointment, you will need to confirm that you have a severely weakened immune system and one of the conditions listed above.

You are welcome to schedule at a location outside of Penn Medicine. Please let us know if you receive an additional dose, so we can update your medical record.

People with weakened immune systems have a harder time fighting infections and other diseases and are especially vulnerable to viruses like COVID. The FDA evaluated information on the use of a third dose of the Pfizer-BioNTech or Moderna vaccines in these individuals and determined that a third vaccine dose may increase their protection against COVID. These individuals should receive the additional dose at least 28 days following the two-dose regimen of the same vaccine. The third dose should be the same mRNA vaccine as the primary vaccine series. Currently, there is not data to support the use of an additional vaccine dose after a primary Johnson & Johnson vaccine in people with severely weakened immune systems. The FDA and CDC are working to provide guidance on this issue. 

Adults (Ages 16 and Older): Where to Get the COVID Vaccines

The Pfizer-BioNTech vaccine is fully approved by the FDA for adults ages 16 years and older. The FDA has authorized the emergency use of the Moderna and Johnson & Johnson vaccines for adults 18 years of age and older. We recommend that anyone who is eligible gets vaccinated to protect yourself and others from COVID.

Vaccine Locations at Penn Medicine

To schedule a vaccine appointment at one of the Penn Medicine locations listed below, please call our COVID-19 Vaccine Scheduling Hotline at 267-758-4902. We answer calls between 8 am and 5 pm on Monday through Friday. We also have walk-in hours (where appointments are not necessary) at some of our vaccine clinics. 

Penn Medicine Chester County Hospital

701 E Marshall St, West Chester, PA 19380

Please visit the Chester County Hospital website for more information and updates.

Penn Medicine Lancaster General Health

555 N Duke St, Lancaster, PA 17602

Please visit the Lancaster General Health website for more information on how to schedule an appointment.

Penn Medicine Princeton Health

1 Plainsboro Rd, Plainsboro Township, NJ 08536

Please visit the Princeton Health website for more information and updates. 

Penn Medicine Valley Forge 

1001 Chesterbrook Blvd, Berwyn, PA 19312

By Appointment Only

Pennsylvania Hospital, Hall Mercer Building

245 S. 8th Street, Philadelphia, PA 19107

Walk-ins welcome: Thursday and Friday, 8:30 am - 11:15 am and 12:15 pm - 3:00 pm

Penn Presbyterian Medical Center

51 N. 39th Street, Philadelphia, PA, 19104 - 1st floor lobby, Wright Saunders Building

Walk-ins welcome: Wednesday and Friday, 8:30 am - 3:30 pm

Perelman Center for Advance Medicine

3400 Civic Center Boulevard, Philadelphia, PA 19104 - 15th floor - South Pavilion

By Appointment Only

The Theater of the Living Arts (TLA)

This location is now closed. We moved the clinic to the Hall Mercer Building at Pennsylvania Hospital

Adolescents (Ages 12-15): Where to Get the Pfizer COVID Vaccine

The FDA has authorized the emergency use authorization for the Pfizer-BioNTech COVID-19 vaccine to adolescents 12 through 15 years old. Currently, we are offering the Pfizer vaccine to adolescents in the following Penn Medicine locations. Please note: Those under 18 must be accompanied by a parent or legal guardian.

Penn Medicine Chester County Hospital

To schedule, call the vaccine scheduling hotline at 267-758-4902.

Penn Medicine Lancaster General Health

For more information, please visit the Lancaster General Health website

Penn Medicine Princeton Health

Register with the New Jersey Vaccine Scheduling System (NJVSS) online and select "Penn Medicine Princeton Medical Center".

Children's Hospital of Philadelphia (CHOP)

For more information, please visit the CHOP website

Who Should Get the COVID Vaccine


If you have any questions about a COVID vaccine and whether you should receive it, please contact your health care provider.

We recommend that you speak with your doctor before receiving the vaccines if you have any of the following conditions:

  • A history of severe allergic reactions or anaphylactic reaction to a medication or vaccine
  • A bleeding disorder
  • Are taking a blood thinner
  • Are immunocompromised
  • Are taking a medicine that affects your immune system
  • Are pregnant or plan to become pregnant
  • Are breastfeeding

Have questions about the COVID-19 vaccines?

Check out our frequently asked questions (FAQs) for more information on vaccine safety, getting vaccinated and booster shots.

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