COVID-19 Clinical Trials

The Randomized Elimination or ProLongation of Angiotensin Converting Enzyme inhibitors and angiotensin receptor blockers in Coronavirus Disease 2019. The purpose of the study is to compare the effect of stopping versus continuing ACEI or ARBs in patients who have COVID-19.

Only patients admitted to the hospital and on a ventilator for treatment of COVID-19 are eligible to participate. The purpose of this study is to develop a possible new treatment for COVID-19 disease which uses antibodies against this virus.

Penn Medicine is seeking plasma donation from eligible healthy volunteers for a research study. Interested volunteers must have recovered from a COVID-19 positive diagnosis (made by collection of a swab of the nose or throat).

You are being invited to participate in an anonymous survey to gain insight into your experience during the COVID-19 pandemic. The following survey was developed to obtain information on what you are experiencing during your confinement, which may include working from home.

While there is a limited supply of personal protective equipment (PPE) during the Covid-19 pandemic, there is a larger availability of surgical masks compared to N95 masks. We plan to perform a prospective cohort study to study the fit factor of a modified surgical mask compared to that of a N95 mask and the unmodified standard surgical mask.

The purpose of this study is to understand how the body learns to fight infections, through influenza vaccination or after SARS-CoV2 infection that causes COVID-19.

The ACTIV-2 Study is testing an investigational medicine to see if they are safe and can help adults with COVID-19 get better. We also want to see if this study drug is safe, can stop the disease process and prevent hospitalization.

The purpose of this research study is to understand how our patients with Multiple Sclerosis (MS) and other neuroimmune disorders are being affected by the COVID-19 outbreak.

We are interested in comparing 3 care conditions to determine which condition is best to help people with opioid use disorder (OUD) and mental illness reduce their drug use and improve their psychiatric symptoms.

The overall purpose of the biobank is to collect and store biological specimens, such as blood, urine, respiratory specimens, other bodily fluids, and tissue where available, as well as health information of people who may or may not have been exposed to the SARS-CoV-2 virus as well as those who have developed COVID-19 disease.. Storing these samples and this information allows researchers to use them for research studies, including but not limited to COVID-19.

The purpose of this study is to determine if it is safe to take Cyclosporine for up to two weeks in patients who have COVID-19 infection. The reason this is important for people afflicted with the COVID-19 virus is that an over active immune system leading to cytokine release syndrome is thought to cause death in some patients.

This open-label, controlled, phase 1 trial will assess the safety and efficacy of convalescent plasma in severely ill, hospitalized participants with pneumonia due to COVID-19.

This trial will study the safety and efficacy of Remdesivir in combination with either Dexamethasone or Baracitinib in adults that are hospitalized with COVID-19.

The primary goal of this study is to assess use of an aerosol biocontainment device for planned airway procedures under general anesthesia.

The main purpose of this study is to try a new type of laboratory test for COVID-19 (also called SARS-CoV-2 or novel coronavirus). This study hopes to collect more information about who is most as risk from this disease, how it affects different types of people, and how to test for it.

Phase 2/3 study of INO-4800 DNA vaccine for SARS-CoV-2 to assess safety, efficacy & immunogenicity of vaccine in health volunteers at high risk for SARS-CoV-2 exposure. INO-4800 1.0mg or placebo given by intradermal injection followed by electroporation using CELLECTRA2000 investigational device at Day 0 and Day 28.

This research study is looking at experimental drugs to prevent the COVID-19 disease from occurring in people who have been exposed to the SARS-CoV-2 virus. The study drugs target the virus that causes COVID-19 and are designed to make it harder for the virus to infect you.

This will be an observational study to investigate the feasibility and efficacy of a home-based, tech enabled, remotely supervised, cardiac rehabilitation (CR) program in qualifying American adults who cannot participate in traditional center based rehab.