Laboratory for Advanced Computed Tomography Imaging Team Photo 2020
Front row(L to R): Nadav Shapira, Peter Noël, Leening Liu, Wenchao Cao; Back: Michael Geagan, Kai Mei, Amy Perkins, Sebastian Meyer


The Laboratory for Advanced Computed Tomography Imaging is dedicated to developing next generation x-ray and computed tomography solutions to provide clinicians with information that exceeds present clinical standards.

When it comes to diagnostics and therapy monitoring, the current tendency is to look at simple "gray values" and contrast differences to determine whether anatomical or pathological changes have occurred. Our long-term vision is to play an active role in the fundamental transformation of x-ray-based imaging towards a diagnostics and therapy tool assisting on the biomolecular level with novel contrast mechanisms.

We address the whole imaging chain by employing cross-discipline approaches, ranging from novel x-ray detection concepts to machine-learning algorithms. Our strong collaboration with experts in clinical departments and the medical device industry guides and accelerates the translation of novel technologies into early clinical applications. The Laboratory for Advanced Computed Tomography Imaging is located in the Department of Radiology of the Perelman School of Medicine at the University of Pennsylvania.

Recent Publications

1. Willemink MJ,  Noël PB. The evolution of image reconstruction for CT—from filtered back projection to artificial intelligence. Eur Radiol. 2019 May; 29(5), 2185-2195.

2. Mechlem K, Ehn S, Sellerer T, Braig E, Münzel D, Pfeiffer F, Noël PB. Joint statistical iterative material image reconstruction for spectral computed tomography using a semi-empirical forward model. IEEE transactions on medical imaging, June 2018, 37(1), 68-80.

3. Gromann LB, De Marco F, Willer K, Noël PB, Scherer K, Renger B, et al. In-vivo x-ray dark-field chest radiography of a pig. Sci Rep. 7, July 2017, 4807.

4. Ehn S, Sellerer T, Muenzel D, Fingerle AA, Kopp F, Duda M, et al. Assessment of quantification accuracy and image quality of a full‐body dual‐layer spectral CT system. J Appl Clin Med Phys., 2018 Jan; 19(1), 204-217.

5. Muenzel D, Bar-Ness D, Roessl E, Blevis I, Bartels M, Fingerle AA, et al. Spectral photon-counting CT: Initial experience with dual–contrast agent K-edge colonography. Radiology, 2017 Jun; 283(3), 723-728. 

Open Positions

Scientist or Postdoctoral Researcher in Biomedical Imaging 
Dr. Noël's Laboratory for Advanced Computed Tomography Imaging in the Radiology Department of the University of Pennsylvania seeks a full-time postdoctoral researcher with expertise in biomedical imaging. A candidate for this position should hold a Ph.D. in one of the following or closely related fields: physics, bioengineering, computer sciences, mechanical engineering, or electrical engineering. Prior work experience in the area of biomedical imaging is highly desirable. A strong background in x-ray imaging, image reconstruction, and/or machine learning is a plus. The applicant should be highly motivated, exhibit excellent interpersonal and communication skills, and be able to prioritize multiple tasks.

Mechanical Engineer in Biomedical Imaging 
A candidate for this position should hold a Bachelor's degree in Mechanical, Manufacturing, Electrical Engineering or a related field. Duties of this position include design, optimization and implementation of experimental x-ray and CT imaging setups. Additional duties will be to keep laboratory space in safe and operational working order. The successful candidate will have demonstrated the ability to work independently and meet objectives in a timely manner. Knowledge of 3-D printing and CAD modelling is a plus.

Undergraduates and Master's students as well as individuals seeking a visiting research fellowship, are also encouraged to contact Dr. Noël about working in the Laboratory for Advanced Computed Tomography Imaging.

All applicants should send an email with attached CV explaining their interest in the position to Dr. Noël.

Contact Information

Dr. Peter Noël
Laboratory for Advanced Computed Tomography Imaging
University of Pennsylvania
Department of Radiology
3400 Spruce Street, One Silverstein
Philadelphia, PA 19104
Office: +1 (215) 898-8212


In This Section:

  • Personnel

    Meet the researchers, faculty and staff at the Laboratory for Advanced Computed Tomography Imaging (LACTI).

  • PixelPrint

    PixelPrint technology was developed by the LACTI team at Penn Medicine and helps improve CT imaging.

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