Department of Radiology

Measuring bone metastasis early response to therapy using FDG PET/CT  Measuring changes in glutamine metabolism  after glutaminase inhibtion using [18F]fljuoroglutamine

Focus

This program focuses on molecular imaging methods to guide individualized, precision medicine treatment for breast cancer patients with the goal of more effective, less toxic treatment. Research also seeks to elucidate the in vivo biology of breast cancer, using imaging. Current research focuses mostly on PET-based method to imaging cancer metabolism, proliferation and quiescence, tumor receptor expression and response to targeted therapy. The program brings together faculty specialists and key staff with experience in molecular imaging, breast imaging, oncology, breast surgery, clinical imaging study design and data analysis.

 

Faculty And Staff

David A. Mankoff, MD, PhD

David A. Mankoff, MD, PhD

Director, PET Center
Vice Chair, Research, Radiology
Gerd Muehllehner Professor of Radiology

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Amy S. Clark, MD, MSCE

Amy S. Clark, MD, MSCE

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

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Robert K. Doot, PhD

Robert K. Doot, PhD

Research Assistant Professor of Radiology

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Elizabeth S. McDonald, MD

Elizabeth S. McDonald, MD

Program Director, Breast/Women's Imaging Fellowship
Assistant Professor of Radiology at the Hospital of the University of Pennsylvania

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Hsiaoju(Sharon) Lee

Researcher
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Prashanth Padakanti, PhD

Researcher
Head shot of Austin Pantel

Austin Ryan Pantel, MD

Assistant Professor of Radiology at the Hospital of the University of Pennsylvania

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Erin Schubert

NMROC Administrator
Rong Zhou, PhD

Rong Zhou, PhD

Research Associate Professor of Radiology

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Recent Publications

1. Zhou R, Pantel AR, Li S, Lieberman BP, Ploessl K, Choi H, Blankemeyer E, Lee H, Kung HF, Mach RH, Mankoff DA. [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition. Cancer Res. 2017 Mar 15;77(6):1476-1484.

2. Pantel AR, Ackerman D, Lee SC, Mankoff DA, Gade TP. Imaging Cancer Metabolism: Underlying Biology and Emerging Strategies. J Nucl Med. 2018 Sep;59(9):1340-1349

3. Liao GJ, Clark AS, Schubert EK, Mankoff DA. 18F-Fluoroestradiol PET: Current Status and Potential Future Clinical Applications. J Nucl Med. 2016 Aug;57(8):1269-75.

Contact Us

Berger, Theresa
PSOM Research Coordinator
Email: theresa.berger@uphs.upenn.edu
Phone: 215-746-2813

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