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Elizabeth S. McDonald, MD

Elizabeth S. McDonald, MD Physician

Program Director, Breast/Women's Imaging Fellowship Assistant Professor of Radiology at the Hospital of the University of Pennsylvania

Dr. McDonald is a Penn Medicine employed physician.

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Clinical Specialties


  • Radiology

Programs & Centers:

Board Certification:

  • Diagnostic Radiology, 2008

Practice Locations and Appointments

  • Penn Radiology

    Hospital of the University of Pennsylvania 3400 Spruce Street Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

  • Penn Radiology

    Penn Medicine Bucks County 777 Township Line Road Yardley, PA 19067 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

  • Penn Radiology

    Penn Presbyterian Medical Center Cupp Pavilion 51 N. 39th Street Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of Penn Presbyterian Medical Center

  • Penn Radiology

    Perelman Center for Advanced Medicine Atrium, Ground Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

  • Penn Radiology

    Penn Medicine Radnor 250 King of Prussia Road Radnor, PA 19087 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

  • Penn Radiology

    Penn Medicine University City 7th Floor 3737 Market Street Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of Penn Presbyterian Medical Center

  • Penn Radiology

    Penn Medicine Valley Forge 1001 Chesterbrook Boulevard Berwyn, PA 19312 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Amerihealth
  • NJ Medicaid
  • NJ Medicare
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Mayo Medical School
Residency: Mayo Clinic
Fellowship: Mayo Clinic
Fellowship: University of Washington Hospital and Clinics


Abramson Cancer Center of the University of Pennsylvania , National American Academy of Neurology, National American Association for Cancer Research, National American Association for Women Radiologists, National American College of Physicians-American Society of Internal Medicine, National American College of Radiology-Member reviewer ACR Practice Guidelines and Technical Standards: "Screening and Diagnostic Mammography.", National American Medical Association (AMA)2002-2003, Alternate Delegate to the Physican House of Delegates, 2002 AMA Policy Advisor, "Low cost drugs to poor countries during times of pandemic health crisis." Resolution 402 passed AMA-House of Delegates (Annual Meeting 2002). 2000-2001, Alternate Delegate to the Student House of Delegates (Mayo Medical School), National American Roentgen Ray Society, National Association of University Radiologists, National Institute for Translational Medicine and Therapeutics, National Mayo Alumni Association, National Minnesota Medical Association (2001-2002) Delegate 1998, Committee on Ethics and Medical-Legal Affairs, Local Radiological Society of North America, National Society for Neuroscience, National Society of Breast Imaging, National Society of Interventional Radiology, National Society of Thoracic Radiology, National The Doctor's Mayo Society of the Mayo Clinic Alumni Association, National

Hospital Affiliation

Dr. McDonald is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Zuckerman S,Conant EF,Keller B,Weinstein S,McDonald ES.: Implementation of synthesized 2D mammography in a population-based digital breast tomosynthesis screening program Radiology : 2016.

McDonald ES, Mankoff DA, Mach RH: Novel strategies for breast cancer imaging: new imaging agents to guide treatment J Nuc Med 57 : 69S-74S,2016.

McDonald ES, Oustimov A, Weinstein SP, Synnestvedt M, Schnall MD, Conant EF: Effectiveness of digital breast tomosynthesis compared with digital mammography: Outcomes analysis from 3 years of breast cancer screening JAMA Oncology 2 (6): 2016.

Cruz, L, McDonald, ES, Mick, R, Czerneicki, B: Anti-HER2 Th1 Response is Superior to Breast MRI in Response to Neoadjuvant Chemotherapy in Patients with HER2 Positive Breast Cancer Annals of Surgery : 2016.

Lowenfeld, L, Zaheer, S, Oechsle, C, Fracol, M, Datta, J, Xu, S, Fitzpatrick, E, Roses, RE, Fisher, CS, McDonald, ES, Zhang, PJ, DeMichele, A, Mick, R, Koski, GK, Czerniecki, BJ.: Addition of Anti-Estrogen Therapy to Anti-HER2 Dendritic Cell Vaccination Improves Regional Nodal Immune Response and Pathologic Complete Response Rate in Patients with ERpos/HER2pos Early Breast Cancer. Oncoimmunology : 2016.

Naha PC, Lau KC, Hsu JC, Hajfathalian M, Mian S, Chhour P, Uppuluri L, McDonald ES, Maidment AD, Cormode DP: Gold silver alloy nanoparticles (GSAN): an imaging probe for breast cancer screening with dual-energy mammography or computed tomography. Nanoscale 8 (28): 13740-54,2016.

Makvandi, M, Xu, K, Lieberman, BP, Anderson, R, Effron, SS, Winters, H, Zeng, C, McDonald, ES, Pryma, DA, Greenberg, RA, Mach, RH.: A radiotracer strategy to quantify PARP-1 expression in vivo provides a biomarker that can enable patient selection for PARP inhibitor therapy. Cancer Research : 2016.

McDonald ES, Hammersley JA, Chou SS, Rahbar H, Scheel JR, Lee CI, Liu CL, Lehman CD, Partridge SC.: Performance of DWI as a Rapid Unenhanced Technique for Detecting Mammographically Occult Breast Cancer in Elevated-Risk Women with Dense Breasts. AJR Am Journal of Roentgenol : W1-W12,2016.

McDonald ES, Clark A, Tchou J, Zhang, P, Freedman, G.: Clinical diagnosis and management of breast cancer J Nuc Med 57 : 9S-16S,2016.

Conant, EF, Keller, BM, Gastounioti, A, McDonald, ES, Kontos, D.: Agreement between Breast Percent Density Estimations from Standard-Dose versus Synthetic Digital Mammograms: Results from a Large Screening Cohort Using Automated Measures. Radiology : 2016.

Chen L, Ray S, Keller BM, Pertuz S, McDonald ES, Conant EF, Kontos D: The Impact of acquisition dose on quantitative breast density estimation with digital mammography: Results from ACRIN PA 4006 Radiology : 2016.

Korhonen K, Weinstein S, McDonald ES, Conant EC: Strategies for increasing cancer detection: a review of true positives and false negatives in screening with digital breast tomosynthesis Radiographics : 2016.

Rahbar, H, McDonald, ES, Lee, JM, Partridge, SC, Lee, CI.: How Can Advanced Imaging Be Used to Mitigate Potential Breast Cancer Overdiagnosis? Academic Radiology : 2016.

McDonald ES, McCarthy AM, Akhtar A, Synnestvedt A, Schnall M, Conant EF: Baseline screening mammography: Performance of full field digital versus digital breast tomosynthesis American Journal of Roentgenology 205 (5): 1143-8,2015.

Zuckerman, S, Weinstein, SW, McDonald, ES, Conant, E: A pictorial essay of synthetic tomosynthesis American Journal of Roentgenol : 2016.

Makvandi M, Tilahun ED, Lieberman BP, Anderson RC, Zeng C, Xu K, Hou C, McDonald ES, Pryma DA,Mach RH: The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer Biochem Biophys Res Commun (BBRC) 467 (4): 1070-1075.,2015.

Mitsumori LM, McDonald ES, Wilson GJ, Neligan PC, Minoshima S, Maki JH: MR Lymphangiography: How I do it J Magn Reson Imaging 42 (6): 1465-77,2015.

Mahrooghy M, Ashraf A, Days D, Mcdonald ES, Rosen M, Mies C, Feldman M, Kontos D. : Pharmacokinetic tumor heterogeneity as a prognostic biomarker for classifying breast cancer recurrence risk IEEE Trans Biomed Eng. 62 (6): 1585-94,2015.

Pertuz S, McDonald ES, Weinstein SP, Conant EC, Kontos D: Fully-automated quantitative estimation of volumetric breast density from digital breast tomosynthesis images: Preliminary results and comparison with digital mammography and magnetic resonance imaging Radiology : 150277,2015.

Clark AS, McDonald E, Lynch MC, Mankoff D: Using nuclear medicine imaging in clinical practice: update on PET to guide treatment of patients with metastatic breast cancer Oncology 28 (5): 424-30,2014.

Doot RK, McDonald ES, Mankoff DA: Role of PET quantitation in the monitoring of cancer response to treatment: review of approaches and human clinical trials Clin Transl Imaging 2 (4): 295-303,2014.

McDonald ES, Schopp JG, Peacock S, DeMartini WB, Rahbar H, Lehman CD, Partridge SC: Diffusion-weighted MRI: association between patient characteristics and apparent diffusion coefficients of normal breast fibroglandular tissue at 3 T AJR Am J Roentgenol 202 (5): W496-502,2014.

Derakhshan JJ, McDonald ES, Siegelman ES, Schnall MD, Wehrli FW: Chemical shift artifact of the third kind: Implications for gradient-echo based contrast enhanced imaging Accepted for ISMRM : 2016.

Mirzabeigi MN, McDonald ES, Chu MW, Fischer JP, Basta M, Kovach S, Wu LC, Serletti J, Kanchwala S: Operative management of locoregional cancer recurrence following post-mastectomy breast reconstruction-indications and outcomes American Society for Reconstructive Microsurgery : 2016.

Partridge SC, McDonald ES: Diffusion weighted magnetic resonance imaging of the breast: protocol optimization, interpretation, and clinical applications Magn Reson Imaging Clin N Am 21 (3): 601-624,2013.

Academic Contact Info

Hospital of the University of Pennsylvania
3400 Spruce Street, 1 Silverstein

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)