Amy S. Clark, MD, MSCE
Medical Oncology
Accepting new patients
Sees patients age 18 and up
Rena Rowan Breast Center
Headshot of Amy S. Clark, MD, MSCE
Penn Medicine Provider

About me

  • Deputy Director, Breast Cancer Clinical Trials
  • Jill and Alan Miller Associate Professor in Breast Cancer Excellence

Education and training

  • Medical School: Penn State Milton S. Hershey Medical Center
  • Residency: Boston Medical Center
  • Fellowship: University of Pennsylvania Health System

What my patients think about me

Average Rating

424 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
February 2026
addresses all my concerns, listens attentively and answers all my questions
Anonymous
February 2026
she is wonderful
Anonymous
February 2026
Dr. Clark is very warm, personable, and knowledgeable.
Anonymous
January 2026
dr clark is smart and knowledgeable and kind and personable

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. Clark is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Jung W, Ko K, Smith AM, Huang A, Xia C, Martei YM, Narayan VK, Clark AS, Lefebvre B, McDermott K, Koropeckyj-Cox D, Fasan O, Hutsell A, Daniels A, Englefield V, Leger KJ, Getz KD, Narayan HK, Marshall JD, Powell-Wiley TM, Yancy CW, Ky B. Air Pollution and Cardiac Remodeling and Function in Patients With Breast Cancer , JAMA Netw Open. : 2026


Magbanua MJM, Manon NA, Wolf DM, Rivero-Hinojosa S, Ahmed Z, Sayaman RW, Tin A, Renner D, Kalashnikova E, Brown-Swigart L, Hirst GL, Yau C, Li W, Isaacs C, Shatsky RA, Clark AS, Zimmer A, Delson AL, Rodriguez A, Liu MC, Pohlmann PR, Esserman LJ, Rugo HS, DeMichele A, van 't Veer L. Circulating tumor DNA refines risk stratification of neoadjuvant therapy-resistant breast tumors , Nat Commun.: 2025


R. Jaber Chehayeb; P. Coutifaris; F. White; J. Heintz; S. L. Jacob; J. Q. Zhang; O. M. Fayanju; E. S. Lebrow; N. Taunk; K. Lee; H. Knollman; I. Makhlin; A. Clark; R. Jankowitz; A. Nayak; S. Domchek; A. DeMichele; P. D. Shah Factors associated with pCR and distant recurrence in patients with early-stage TNBC treated with KN522 , San Antonio Texas Breast Cancer Symposium, San Antonio, TX : 2025


Paula R. Pohlmann, Hope S. Rugo, Christina Yau, Douglas Yee, A. Jo Chien, Nicole Williams, Anne M. Wallace, Judy C. Boughey, Christos Vaklavas, Mili Arora, Virginia Borges, Amy S. Clark, Coral Omene, Claudine Isaacs, Erica Stringer-Reasor, Rita Nanda, Carla Falkson, Kathy S. Albain, Nancy Chan, Evanthia Roussos Torres, Mariya Rozenblit, Jennifer Tseng, Satya Bommakanti, Chaitali Nangia, Lamorna Brown-Swigart, Gillian L. Hirst, Neel Pasricha, Crystal H. Kretzer, Jane Perlmutter, Alexander Borowsky, W. Fraser Symmans, Laura van ‘t Veer, Nola Hylton, Laura J. Esserman Pathologic complete response rates (pCR) after the novel HER2 ADC ARX788 in the neoadjuvant setting: Results from the I-SPY2.2 trial , San Antonio Texas Breast Cancer Symposium, San Antonio, TX : 2025


Chien, J., Mukhtar, R.A., Yau, C., Elias, A. D., Wallace, A. M., Chan, N., Omene, C., Tseng, J., Trivedi, M. S., Stringer-Reasor, E., Yee, D., Clark, A. S., Thomas, A., Han, H., Arora, M., Nangia, C., Albain, K., Falkson, C., Isaacs, C., Zimmer, A., Rozenblit, M., van 't Veer, L., Swigart, L. B., Hirst, G. L., Symmans, W. F., Borowsky, A. D., Onishi, N., Hylton, N., Alkhafaji, S., Giridhar, K. V., Vaklavas, C., Wei, M., Goetz, M. P., Chen, N., Olopade, O., Huppert, L., Wu, C., Esserman, L. J. I-SPY2 Endocrine Optimization Pilot (EOP): Neoadjuvant vepdegestrant monotherapy or in combination with letrozole or abemaciclib in molecularly selected patients (pts) with HR+ HER2- Stage 2/3 breast cancer (BC) , San Antonio Breast Cancer Symposium, San Antonio, TX: 2025


Xia C, Smith AM, Lefebvre B, Jamal FA, Armenian SH, Koropeckyj-Cox D, Zhang L, Liu PP, Landsburg D, Clark AS, Shah PD, Hubbard RA, Huang A, Golec S, Hewitt M, Wilcox NS, Chen Z, Rethy L, Jung W, Ko K, Narayan V, Martei YM, Lang NN, Januzzi JL, Felker GM, Ky B. Biomarker-Guided Cardioprotection for Patients Treated With Anthracyclines: A Randomized Clinical Trial , JAMA Netw Open.: 2025


DeMichele, A., Clark, A. S., Shea, E., Bayne, E. J., Sterner, C. J., Rohn, K., Dwyer, S., Pan, T., Nivar, I., Chen, Y., Wileyto, P., Berry, L. R., Deluca, S., Savage, J., Makhlin, I., Pant, D. K., Martin, H., Egunsola, A., Mears, N., Goodspeed, B. L., Chislock, E. M., Graves, J., Wang, J., Shih, N., Belka, G. K., Berry, D., Nayak, A., Feldman, M., & Chodosh, L. A. Targeting dormant tumor cells to prevent recurrent breast cancer: a randomized phase 2 trial , Nature Medicine : 2025


Clark, A. S., Zhao, F., Klein, P., Montero, A. J., Falkson, C., Krill-Jackson, E., Rowland, K., Sardesai, S., Incorvati, J., Dillon, P., Wolff, A. C., Trauger, R., Heineman, T. C., Coffey, M. C., & Miller, K. D. A Phase II Randomized Study of Paclitaxel Alone or Combined with Pelareorep with or without Avelumab in Metastatic Hormone Receptor-Positive Breast Cancer: The BRACELET-01/PrE0113 Study , Clinical cancer research: 2025


Jung W, Hubbard RA, Smith AM, Ko K, Huang A, Wang J, Isaacs JM, Zhang L, Liu PP, Chen Z, Shah PD, Mintzer D, Bhattacharya S, Knollman HM, Clark AS, Koropeckyj-Cox D, Messinger M, Wilcox NS, Xia C, Narayan V, Upshaw JN, Armenian SH, Ky B. Risk-guided cardioprotection with carvedilol in patients with breast cancer (CCT guide): a phase 1 randomized clinical trial. , Breast Cancer Res Treat: 2025


Garrido-Castro, C. A., Gorthi, A., Kim S.E., D'Ippolito, A., Nanda, R., Abdou, Y., Clark, A. S., Sacks, R. L., O'Connor, T. P., Sinclair, N., Lo, K.M.S., Desrosiers, J., Lin, N. U., Burstein, H. J., Mittendorf, E.A., Painter, C., Eaton, M. L., Barrett, C., Tayob, N., Tolaney, S.M. Cell-free circulating chromatin profiles enable epigenomic characterization of mechanisms of response and resistance to sacituzumab govitecan in breast cancer , 2025 ASCO Annual Meeting: 2025