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Amy S. Clark, MD, MSCE

Amy S. Clark, MD, MSCE Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Clark is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties


  • Medical Oncology

Programs & Centers:

Board Certification:

  • Internal Medicine, 2009
  • Medical Oncology, 2012

Clinical Expertise:

  • Breast Cancer

Description of Clinical Expertise

I am a medical oncologist who specializes in breast cancer. I only see breast cancer patients in the outpatient setting, but treat patients will all cancers when working in the hospital.

Practice Locations and Appointments

  • Rena Rowan Breast Center

    Abramson Cancer Center Perelman Center for Advanced Medicine, West Pavilion, 3rd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Penn State Milton S. Hershey Medical Center
Residency: Boston Medical Center (Formerly Boston City Hospital)
Fellowship: Hospital of the University of Pennsylvania


American Society of Clinical Oncology, National

Hospital Affiliation

Dr. Clark is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My research focuses on clinical trials and drug development for those with early stage and metastatic breast cancer. I also seek to develop novel predictive biomarkers specifically using molecular imaging as companions to early phase trials.

Selected Publications:

Finkelman Brian S, Putt Mary, Wang Teresa, Wang Le, Narayan Hari, Domchek Susan, DeMichele Angela, Fox Kevin, Matro Jennifer, Shah Payal, Clark Amy, Bradbury Angela, Narayan Vivek, Carver Joseph R, Tang W H Wilson, Ky Bonnie: Arginine-Nitric Oxide Metabolites and Cardiac Dysfunction in Patients With Breast Cancer. Journal of the American College of Cardiology 70 (2): 152-162,2017.

Vonderheide Robert H, Domchek Susan M, Clark Amy S: Immunotherapy for Breast Cancer: What Are We Missing? Clinical cancer research : an official journal of the American Association for Cancer Research 23 (11): 2640-2646,2017.

Alexander I. Spira, Omid Hamid, Todd M. Bauer, Virginia F. Borges, Jeffrey S. Wasser, David C. Smith, Amy S. Clark, Emmett V. Schmidt, Yufan Zhao, Janet E. Maleski, Tara C. Gangadhar: Efficacy/safety of epacadostat plus pembrolizumab in triple-negative breast cancer and ovarian cancer: phase 1/2 ECHO-202 study. Journal of Clinical Oncology 35 ((suppl; abstr 1103)): 2017.

Katrina Korhonen, MD, Marsha C. Lynch, MD, Austin R. Pantel, MD, Angela R. Bradbury, MD, Susan Domchek, MD, Jennifer Matro, MD, Payal Shah, MD, Angela DeMichele, MD, MSCE, John H. Glick, MD, David A. Mankoff, MD, PhD, Amy S. Clark, MD: Patterns of Early Response to Endocrine Therapy seen on FDG PET/CT in Bone-Dominant Metastatic Breast Cancer: an Interim Analysis Proceedings of the Society of Nuclear Medicine and Molecular Imaging, Denver, CO (Abstract 469): 2017.

Rita Nanda, Minetta C. Liu, Christina Yau, Smita Asare, Nola Hylton, Laura Van't Veer, Jane Perlmutter, Anne M. Wallace, Amy Jo Chien, Andres Forero-Torres, Erin Ellis, Heather Han, Amy Sanders Clark, Kathy S. Albain, Judy Caroline Boughey, Anthony D. Elias, Donald A. Berry, Douglas Yee, Angela DeMichele, Laura Esserman: Pembrolizumab plus standard neoadjuvant therapy for high-risk breast cancer (BC): Results from I-SPY 2. Journal of Clinical Oncology 32 (abstr 506): 2017.

Mankoff David A, Farwell Michael D, Clark Amy S, Pryma Daniel A: Making Molecular Imaging a Clinical Tool for Precision Oncology: A Review. JAMA oncology 3 (5): 695-701,2017.

Aditya Bardia, Sara Hurvitz, Denise A. Yardley, Amelia Zelnak, Angela DeMichele, Amy S. Clark, Das Purkayastha, Tania Small, 6 Christopher Tucci, 6 Stacy Moulder: TRINITI-1: Ribociclib + everolimus + exemestane triplet combination in men or postmenopausal women with HR+, HER2– advanced breast cancer following progression on a cyclin-dependent kinase 4/6 inhibitor Proceedings of the San Antonio Breast Cancer Symposium, San Antonio, TX : 2016.

Angela DeMichele, Amy Clark, Robin Holmes, Melissa Volpe, Christopher Medrano, Andrea Troxel1, Anna Kalota, Kevin R. Fox, Susan M. Domchek, Jennifer Matro, Angela R. Bradbury, Natalie Shih, Michael Feldman, Elizabeth O. Hexner, Jacqueline F. Bromberg: Targeting Inflammatory Pathways: A Phase II Trial of the JAK-inhibitor Ruxolitinib in Combination with Exemestane for Aromatase Inhibitor Resistant, Estrogen-Receptor Positive Breast Cancer Proceedings of the San Antonio Breast Cancer Symposium, San Antonio, TX : 2016.

Amy S. Clark, Nicholas P. McAndrew, Xingmei Wang, Andrea Troxel, Michael Feldman, Priti Lal, Paul Zhang, John Ndicu, Isoris Nivar, Mark Rosen, Maryann Gallagher, Jessica Burrell, Susan Domchek, Kevin R. Fox, Peter O’Dwyer, Angela DeMichele: Single Agent Palbociclib with or without Trastuzumab for the treatment of Rb+ Advanced Breast Cancer: A Phase II Trial Proceedings of the San Antonio Breast Cancer Symposium, San Antonio, TX : 2016.

Mamtani Ronac, Clark Amy S, Scott Frank I, Brensinger Colleen M, Boursi Ben, Chen Lang, Xie Fenglong, Yun Huifeng, Osterman Mark T, Curtis Jeffrey R, Lewis James D: Association between breast cancer recurrence with immunosuppression in rheumatoid arthritis and inflammatory bowel disease: A cohort study. Arthritis Rheumatol 68 (10): 2403-11,2016.

Academic Contact Info

Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-103
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 662-7096
Patient appointments: 800-789-7366 (PENN)