Amy S. Clark, MD, MSCE
Medical Oncology
Accepting new patients
Sees patients age 18 and up
Rena Rowan Breast Center
Penn Medicine Provider

About me

  • Deputy Director, Breast Cancer Clinical Trials
  • Jill and Alan Miller Associate Professor in Breast Cancer Excellence

Education and training

  • Medical School: Penn State Milton S. Hershey Medical Center
  • Residency: Boston Medical Center
  • Fellowship: University of Pennsylvania Health System

What my patients think about me

Average Rating

412 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

December 2025
love her, very personable
December 2025
she is very knowledgeable and answers all questions!
November 2025
dr.clark was patient and answered all my questions
November 2025
she's amazing!!!

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. Clark is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Chien, J., Mukhtar, R.A., Yau, C., Elias, A. D., Wallace, A. M., Chan, N., Omene, C., Tseng, J., Trivedi, M. S., Stringer-Reasor, E., Yee, D., Clark, A. S., Thomas, A., Han, H., Arora, M., Nangia, C., Albain, K., Falkson, C., Isaacs, C., Zimmer, A., Rozenblit, M., van 't Veer, L., Swigart, L. B., Hirst, G. L., Symmans, W. F., Borowsky, A. D., Onishi, N., Hylton, N., Alkhafaji, S., Giridhar, K. V., Vaklavas, C., Wei, M., Goetz, M. P., Chen, N., Olopade, O., Huppert, L., Wu, C., Esserman, L. J. I-SPY2 Endocrine Optimization Pilot (EOP): Neoadjuvant vepdegestrant monotherapy or in combination with letrozole or abemaciclib in molecularly selected patients (pts) with HR+ HER2- Stage 2/3 breast cancer (BC) , San Antonio Breast Cancer Symposium, San Antonio, TX: 2025


R. Jaber Chehayeb; P. Coutifaris; F. White; J. Heintz; S. L. Jacob; J. Q. Zhang; O. M. Fayanju; E. S. Lebrow; N. Taunk; K. Lee; H. Knollman; I. Makhlin; A. Clark; R. Jankowitz; A. Nayak; S. Domchek; A. DeMichele; P. D. Shah Factors associated with pCR and distant recurrence in patients with early-stage TNBC treated with KN522 , San Antonio Texas Breast Cancer Symposium, San Antonio, TX : 2025


Paula R. Pohlmann, Hope S. Rugo, Christina Yau, Douglas Yee, A. Jo Chien, Nicole Williams, Anne M. Wallace, Judy C. Boughey, Christos Vaklavas, Mili Arora, Virginia Borges, Amy S. Clark, Coral Omene, Claudine Isaacs, Erica Stringer-Reasor, Rita Nanda, Carla Falkson, Kathy S. Albain, Nancy Chan, Evanthia Roussos Torres, Mariya Rozenblit, Jennifer Tseng, Satya Bommakanti, Chaitali Nangia, Lamorna Brown-Swigart, Gillian L. Hirst, Neel Pasricha, Crystal H. Kretzer, Jane Perlmutter, Alexander Borowsky, W. Fraser Symmans, Laura van ‘t Veer, Nola Hylton, Laura J. Esserman Pathologic complete response rates (pCR) after the novel HER2 ADC ARX788 in the neoadjuvant setting: Results from the I-SPY2.2 trial , San Antonio Texas Breast Cancer Symposium, San Antonio, TX : 2025


DeMichele, A., Clark, A. S., Shea, E., Bayne, E. J., Sterner, C. J., Rohn, K., Dwyer, S., Pan, T., Nivar, I., Chen, Y., Wileyto, P., Berry, L. R., Deluca, S., Savage, J., Makhlin, I., Pant, D. K., Martin, H., Egunsola, A., Mears, N., Goodspeed, B. L., Chislock, E. M., Graves, J., Wang, J., Shih, N., Belka, G. K., Berry, D., Nayak, A., Feldman, M., & Chodosh, L. A. Targeting dormant tumor cells to prevent recurrent breast cancer: a randomized phase 2 trial , Nature Medicine : 2025


Clark, A. S., Zhao, F., Klein, P., Montero, A. J., Falkson, C., Krill-Jackson, E., Rowland, K., Sardesai, S., Incorvati, J., Dillon, P., Wolff, A. C., Trauger, R., Heineman, T. C., Coffey, M. C., & Miller, K. D. A Phase II Randomized Study of Paclitaxel Alone or Combined with Pelareorep with or without Avelumab in Metastatic Hormone Receptor-Positive Breast Cancer: The BRACELET-01/PrE0113 Study , Clinical cancer research: 2025


Jung W, Hubbard RA, Smith AM, Ko K, Huang A, Wang J, Isaacs JM, Zhang L, Liu PP, Chen Z, Shah PD, Mintzer D, Bhattacharya S, Knollman HM, Clark AS, Koropeckyj-Cox D, Messinger M, Wilcox NS, Xia C, Narayan V, Upshaw JN, Armenian SH, Ky B. Risk-guided cardioprotection with carvedilol in patients with breast cancer (CCT guide): a phase 1 randomized clinical trial. , Breast Cancer Res Treat: 2025


Garrido-Castro, C. A., Gorthi, A., Kim S.E., D'Ippolito, A., Nanda, R., Abdou, Y., Clark, A. S., Sacks, R. L., O'Connor, T. P., Sinclair, N., Lo, K.M.S., Desrosiers, J., Lin, N. U., Burstein, H. J., Mittendorf, E.A., Painter, C., Eaton, M. L., Barrett, C., Tayob, N., Tolaney, S.M. Cell-free circulating chromatin profiles enable epigenomic characterization of mechanisms of response and resistance to sacituzumab govitecan in breast cancer , 2025 ASCO Annual Meeting: 2025


Clark AS, Zhao F, Klein P, Montero AJ, Falkson C, Jackson EK, Rowland K, Sardesai S, Incorvati J, Dillon P, Wolff AC, Trauger R, Heineman TC, Coffey MC, Miller KD BRACELET-01/PrE0113: A Phase II Randomized Study of Paclitaxel (Pac), Pac/Pelareorep (Pel) or Pac/Pel/Avelumab in Metastatic Hormone Receptor Positive Breast Cancer , Clinical Cancer Research : 2025


Gitto, S. B., Pantel, A. R., Maxwell, K. N., Pryma, D. A., Farwell, M. D., Liu, F., Cao, Q., O'Brien, S. R., Clark, A. S., Shah, P. D., & McDonald, E. S. FluorThanatrace PET imaging as a biomarker of response to PARP inhibitors in breast cancer , Communications medicine: 2025


Berlin, E., Ko, K., Ma, L., Messing, I., Hollawell, C., Smith, A. M., Taunk, N. K., Narayan, V., Upshaw, J. N., Clark, A. S., Shah, P. D., Knollman, H., Bhattacharya, S., Koropeckyj-Cox, D., Wang, J., Yegya-Raman, N., Han, I. S., Lefebvre, B., Li, T., Wilcox, N. S., Jung, W., Chen, J., Freedman, G. M., Ky, B. Cardiac Effects of Modern Breast Radiation Therapy in Patients Receiving Systemic Cancer Therapy , JACC. CardioOncology: 2025