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Amy S. Clark, MD, MSCE

Amy S. Clark, MD, MSCE Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Clark is a Penn Medicine employed physician.

Clinical Specialties


  • Medicine
    • Medical Oncology

Programs & Centers:

  • Cancer
    • Breast Cancer Program

Board Certification:

  • Internal Medicine, 2009
  • Medical Oncology, 2012

Clinical Expertise:

  • Breast Cancer

Description of Clinical Expertise

I am a medical oncologist who specializes in breast cancer. I only see breast cancer patients in the outpatient setting, but treat patients will all cancers when working in the hospital.

Practice Locations and Appointments

  • Rena Rowan Breast Center

    Abramson Cancer Center Perelman Center for Advanced Medicine, West Pavilion, 3rd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Penn State Milton S. Hershey Medical Center
Residency: Boston Medical Center (Formerly Boston City Hospital)
Fellowship: Hospital of the University of Pennsylvania


American Society of Clinical Oncology, National

Hospital Affiliation

Dr. Clark is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My research focuses on clinical trials and drug development for those with early stage and metastatic breast cancer. I also seek to develop novel predictive biomarkers specifically using molecular imaging as companions to early phase trials.

Selected Publications:

Clark Amy S, Karasic Thomas B, DeMichele Angela, Vaughn David J, O'Hara Mark, Perini Rodolfo, Zhang Paul, Lal Priti, Feldman Michael, Gallagher Maryann, O'Dwyer Peter J: Palbociclib (PD0332991)-a Selective and Potent Cyclin-Dependent Kinase Inhibitor: A Review of Pharmacodynamics and Clinical Development. JAMA oncology : 1-8,2015.

Farwell Michael D, Clark Amy S, Mankoff David A: How Imaging Biomarkers Can Inform Clinical Trials and Clinical Practice in the Era of Targeted Cancer Therapy. JAMA oncology 1 (4): 421-2,2015.

Mankoff David A, Farwell Michael D, Clark Amy S, Pryma Daniel A: How Imaging Can Impact Clinical Trial Design: Molecular Imaging as a Biomarker for Targeted Cancer Therapy. Cancer journal (Sudbury, Mass.) 21 (3): 218-24,2015.

DeMichele Angela, Yee Douglas, Berry Donald A, Albain Kathy S, Benz Christopher C, Boughey Judy, Buxton Meredith, Chia Stephen K, Chien A Jo, Chui Stephen Y, Clark Amy, Edmiston Kirsten, Elias Anthony, Forero-Torres Andres, Haddad Tufia C, Haley Barbara, Haluska Paul, Hylton Nola M, Isaacs Claudine, Kaplan Henry, Korde Larissa A, Leyland-Jones Brian, Liu Minetta C, Melisko Michelle, Minton Susan E, Moulder Stacy, Nanda Rita, Olopade Olufunmilayo I, Paoloni Melissa, Park John W, Parker Barbara A, Perlmutter : The Neoadjuvant Model is Still the Future for Drug Development in Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research : 2015.

Clark AS, DeMichele A.: The Cyclin D/Cyclin Dependent Kinase 4/6 Complex as a Target in the Treatment of Breast Cancer. Current Breast Cancer Reports 7 (4): 175-182,2015.

17. DeMichele, A, Natalie Shih, N, Koehler, M, Huang Bartlett, C, Jiang, J, Zhu, Z, Hardwick, J, Huang, D, Zheng, X, Clark, AS, Colameco, C, Driscoll, A, Feldman, M, Gallagher, M, Goodman, N, Huj, H, O'Dwyer, P, Rejto, PA: Upregulation of cell cycle pathway genes without loss of RB1 contributes to acquired resistance to single-agent treatment with Palbociclib in breast cancer. San Antonio Breast Cancer Symposium : 2015.

DeMichele, A, Dickson, M, Clark, AS, Colameco, C, Gallagher, M, Gramlich, K, Zafman, K, Lewis, D, Vaughn, D, Schwartz, G, O’Dwyer, P.: Characterization of Isolated, Uncomplicated Neutropenia, Related to the CDK 4/6 Inhibitor Palbociclib. American Association of Clinical Oncology : 2015.

Clark, AS, O'Dwyer, PJ, Wang, X, Troxel, A, Lal, P, Feldman, MD, Gallagher, M, Driscoll, A, Ndicu, J, Nivar, I, Rosen, MA, Matro, J, Bradbury, AR, Domchek, SM, Fox, KR, DeMichele, A: Palbociclib & paclitaxel on an alternating schedule for advanced breast cancer: Results of a phase Ib trial. San Antonio Breast Cancer Symposium : 2015.

Harding, JJ, Telli, ML, Munster, PM, Le, MH, Molineaux, C, Bennett, MK, Mittra, E, Burris, HA, Clark, AS, Dunphy, M, Meric-Bernstam, F, Patel, MR, DeMichele, A, Infante, JR.: Safety and tolerability of increasing doses of CB-839, a first-in-class, orally administered small molecule inhibitor of glutaminase, in solid tumors. J Clin Oncol 33 (suppl; abstr 2512): 2015.

Silber Jeffrey H, Rosenbaum Paul R, Ross Richard N, Niknam Bijan A, Ludwig Justin M, Wang Wei, Clark Amy S, Fox Kevin R, Wang Min, Even-Shoshan Orit, Giantonio Bruce J: Racial disparities in colon cancer survival: a matched cohort study. Annals of internal medicine 161 (12): 845-54,2014.

Academic Contact Info

Perelman Center for Advanced Medicine
3rd Floor, West Pavilion
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 662-7096
Fax: (215) 615-3349
Patient appointments: 800-789-PENN (7366)