Description of Research Expertise:
My research focuses on clinical trials and drug development for those with early stage and metastatic breast cancer. I also seek to develop novel predictive biomarkers specifically using molecular imaging as companions to early phase trials.
Liao Geraldine J, Clark Amy S, Schubert Erin K, Mankoff David A: 18F-Fluoroestradiol PET: Current Status and Potential Future Clinical Applications. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 57 (8): 1269-75,2016.
Mamtani Ronac, Clark Amy S, Scott Frank I, Brensinger Colleen M, Boursi Ben, Chen Lang, Xie Fenglong, Yun Huifeng, Osterman Mark T, Curtis Jeffrey R, Lewis James D: Association between breast cancer recurrence with immunosuppression in rheumatoid arthritis and inflammatory bowel disease: A cohort study. Arthritis & rheumatology (Hoboken, N.J.) : 2016.
Narayan Hari K, French Benjamin, Khan Abigail M, Plappert Theodore, Hyman David, Bajulaiye Akinyemi, Domchek Susan, DeMichele Angela, Clark Amy, Matro Jennifer, Bradbury Angela, Fox Kevin, Carver Joseph R, Ky Bonnie: Noninvasive Measures of Ventricular-Arterial Coupling and Circumferential Strain Predict Cancer Therapeutics-Related Cardiac Dysfunction. JACC. Cardiovascular imaging : 2016.
Clark A S, DeMichele A, Mankoff D: HER2 imaging in the ZEPHIR study. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 27 (4): 555-7,2016.
Clark Amy S, Karasic Thomas B, DeMichele Angela, Vaughn David J, O'Hara Mark, Perini Rodolfo, Zhang Paul, Lal Priti, Feldman Michael, Gallagher Maryann, O'Dwyer Peter J: Palbociclib (PD0332991)-a Selective and Potent Cyclin-Dependent Kinase Inhibitor: A Review of Pharmacodynamics and Clinical Development. JAMA oncology : 1-8,2015.
Farwell Michael D, Clark Amy S, Mankoff David A: How Imaging Biomarkers Can Inform Clinical Trials and Clinical Practice in the Era of Targeted Cancer Therapy. JAMA oncology 1 (4): 421-2,2015.
Mankoff David A, Farwell Michael D, Clark Amy S, Pryma Daniel A: How Imaging Can Impact Clinical Trial Design: Molecular Imaging as a Biomarker for Targeted Cancer Therapy. Cancer journal (Sudbury, Mass.) 21 (3): 218-24,2015.
DeMichele Angela, Yee Douglas, Berry Donald A, Albain Kathy S, Benz Christopher C, Boughey Judy, Buxton Meredith, Chia Stephen K, Chien A Jo, Chui Stephen Y, Clark Amy, Edmiston Kirsten, Elias Anthony, Forero-Torres Andres, Haddad Tufia C, Haley Barbara, Haluska Paul, Hylton Nola M, Isaacs Claudine, Kaplan Henry, Korde Larissa A, Leyland-Jones Brian, Liu Minetta C, Melisko Michelle, Minton Susan E, Moulder Stacy, Nanda Rita, Olopade Olufunmilayo I, Paoloni Melissa, Park John W, Parker Barbara A, Perlmutter : The Neoadjuvant Model is Still the Future for Drug Development in Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research : 2015.
Clark AS, DeMichele A.: The Cyclin D/Cyclin Dependent Kinase 4/6 Complex as a Target in the Treatment of Breast Cancer. Current Breast Cancer Reports 7 (4): 175-182,2015.
Harding, JJ, Telli, ML, Munster, PM, Le, MH, Molineaux, C, Bennett, MK, Mittra, E, Burris, HA, Clark, AS, Dunphy, M, Meric-Bernstam, F, Patel, MR, DeMichele, A, Infante, JR.: Safety and tolerability of increasing doses of CB-839, a first-in-class, orally administered small molecule inhibitor of glutaminase, in solid tumors. J Clin Oncol 33 (suppl; abstr 2512): 2015.