What is a breast biopsy?

A breast biopsy is a minimally invasive needle procedure performed by a specialized radiologist with image-guidance and a local anesthetic to remove a small sample of your breast tissue. After the tissue is removed, it is passed onto a pathologist, who studies the sample to determine whether cancer cells are present. If cancer is detected, a biopsy helps us determine what kind of cancer it is and how to treat it.

Who is a candidate for a breast biopsy?

Your Penn Medicine provider may order a biopsy after the breast radiology team completes your work-up with imaging and recommends a biopsy for a mass or other abnormality. While this may seem scary, a mass does not always mean cancer. Only about 25 percent of women who have a breast biopsy are diagnosed with cancer. However, breast biopsies remain crucial because they are the fastest and least invasive way to confirm or deny a breast cancer diagnosis so that patients can begin treatment as early as possible.

How to prepare for a breast biopsy procedure

Usually, limited preparation is needed for a breast biopsy. You should tell your radiologist about any medications you are taking and bring any results from recent breast imaging (mammograms or ultrasounds) to be reviewed before the procedure. The Breast Radiology team will give you specific instructions on how to prepare for your biopsy, based on which procedure you will have.

Is anesthesia used during a breast biopsy? 

We always use local anesthesia for image-guided needle biopsies and aspirations. For surgical biopsies most patients require general anesthesia. Breast biopsies are most often performed as an outpatient procedure.

What breast biopsy types are used?

We use mammography, ultrasound and MRI to target abnormal tissue and collect samples from the breast. The type of biopsy we use depends on factors including the location, appearance, and size of the abnormal tissue. It also depends on individual patient needs and abilities. Our breast cancer team always performs the least invasive procedure possible that is best for the patient.

How long do biopsy results take?

After extraction of the tissue, the breast biopsy sample is kept at Penn to be analyzed by a specialized pathologist. The tissue must process overnight before it can be examined. After the pathologist reaches a decision, the report of the findings is available to your physician and the radiologist, who will then communicate the results to you. Because of this course of action, breast biopsy results typically take 2-3 working days to reach the patient but may take up to a week or longer depending on the complexity of the case and the tissue sample.

The report will show whether cancer cells were found in your breast. If cancer cells are found, Penn will be with you every step of the way. The pathology report will help you and your breast cancer team make informed decisions about next steps and breast cancer treatment. You will likely be referred for further testing to determine the stage of the cancer, which will help us create a treatment plan that is best for you.

If the report shows that the cells in a lump are benign or noncancerous, you still might require follow-up treatment as recommended by the radiologist, a surgeon, or your doctor.

Why choose Penn Medicine

Our breast cancer team of coordinators, technologists, sonographers, nurses, radiologists, and pathologists use advanced imaging and technology to perform breast biopsies. We offer compassionate care and work quickly to get you the answers you need. At Penn, you’ll find:

  • Skilled radiologists: Our specialized radiologists diagnose patients using core biopsy. Biopsy results take 2-3 working days and eliminate the need for most excisional (surgical) biopsies. Core biopsy is quick, minimally invasive, and provides our breast cancer team with vital information before any surgical procedure or other treatment.
  • Advanced technology: We use state-of-the-art image-guided methods and devices to precisely pinpoint abnormal breast tissue.
  • Dedicated pathologists: Every biopsy is evaluated by a specialized breast pathologist who only works with breast tissue. Our extensive experience means we see details that your tissue is in the hands of experts. The breast cancer diagnosis we deliver is in-depth and accurate.
  • Specialized care close to home: We conduct breast biopsies at all Penn Medicine breast cancer locations. You have access to our team of providers and breast pathologists no matter where you live
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Rated “exceptional” by The National Cancer Institute

Penn Medicine’s Abramson Cancer Center is a world leader in cancer research, patient care, and education. Our status as a national leader in cancer care is reflected in our continuous designation as a Comprehensive Cancer Center by the National Cancer Institute (NCI) since 1973, one of 7 such centers in the United States. The ACC is also a member of the National Comprehensive Cancer Network, one of a select few cancer centers in the U.S., that are working to promote equitable access to high-quality, advanced cancer care.

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