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LSPFI Research Image: MRI-Derived Cerebrovascular Reactivity (CVR)


Research at the Laboratory for Structural, Physiologic and Functional Imaging is primarily focused on the continued development of image-based quantitative methods for the study of tissue oxygen metabolism at enhanced temporal and spatial resolution, and the study of degenerative and acquired vascular disease of the brain and other organ systems, including the human placenta and fetus. A related area of concentration is development of technology for the evaluation of preclinical vascular disease.

LSPFI is also active in developing methods for quantitative assessment of metabolic and degenerative skeletal disorders. Ongoing projects target creation of cranial models and orthopedic applications of high-resolution 3D anatomical models.


Faculty and Staff

Felix Werner Wehrli, PhD

Felix Wehrli, PhD

  • Director, Laboratory for Structural, Functional and Physiologic Imaging
  • Professor of Radiologic Science, Biochemistry and Biophysics

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Hee Kwon Song,  PhD

Hee Kwon Song, PhD

Associate Professor of Radiology

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Chamith S. Rajapakse, PhD

Chamith Rajapakse, PhD

Assistant Professor of Radiology and Orthopaedic Surgery

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Michael C. Langham, PhD

Michael Langham, PhD

Assistant Professor of Radiology

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Hyunyeol Lee, PhD

Research Associate

Alessandra Caporale, PhD

Postdoctoral Researcher

Pei-Hsin Wu, PhD

Postdoctoral Researcher

Alexandria Batzdorf

Research Specialist

Rajiv Deshpande

HHMI Graduate Student

Brandon Jones

Graduate Student

Kelly Sexton

Clinical Research Coordinator

Alyssa Johncola

Clinical Research Coordinator

Holly Stefanow

Associate Director and Project Manager


1. Leonard MB, Wehrli FW, Ziolkowski SL, Billig E, Long J, Nickolas TL, Magland JF, Nihtianova S, Zemel BS, Herskovitz R, Rajapakse CS. A multi-imaging modality study of bone density, bone structure and the muscle - bone unit in end-stage renal disease. Bone. 2019 Oct;127:271-279.

2. Caporale A, Langham MC, Guo W, Johncola A, Chatterjee S, Wehrli FW. Acute effects of electronic cigarette aerosol inhalation on vascular function detected at quantitative MRI. Radiology. 2019 Aug 20:190562. [Epub ahead of print]

3. Chatterjee S, Tao JQ, Johncola A, Guo W, Caporale A, Langham MC, Wehrli FW. Acute exposure to e-cigarettes causes inflammation and pulmonary endothelial oxidative stress in nonsmoking, healthy young subjects. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 1;317(2):L155-L166.

4. Englund EK, Fernández-Seara MA, Rodríguez-Soto AE, Lee H, Rodgers ZB, Vidorreta M, Detre JA, Wehrli FW. Calibrated fMRI for dynamic mapping of CMRO(2) responses using MR-based measurements of whole-brain venous oxygen saturation. J Cereb Blood Flow Metab. 2019 Aug 8:271678X19867276.

5. Ailavajhala R, Oswald J, Rajapakse CS, Pleshko N. Environmentally-controlled near infrared spectroscopic imaging of bone water. Sci Rep. 2019 Jul 15;9(1):10199.


University of Pennsylvania
1 Founders Building
3400 Spruce Street
Philadelphia, PA 19104
Phone: 215-662-7951



Learn more about the Laboratory for Structural, Physiologic and Functional Imaging (LSPFI)

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