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CMROI graphic: Measurement of arterial blood flow pulsatility with optics.

Measurement of arterial blood flow pulsatility with optics.

Focus

The primary goal of the Center for Magnetic Resonance and Optical Imaging (CMROI) is to develop cutting edge core Magnetic Resonance and Optical biomedical imaging technologies for solving important problems in biomedical research with a special emphasis on the rapid clinical translation of these state-of-the art technologies. Specifically, the Resource is focused on the development of quantitative, noninvasive MR and optical imaging based biomarkers for studying tissue metabolism and function, with an eye towards clinical translation through early diagnoses and to facilitate in the development and evaluation of new therapies in a variety of diseases. These technological developments are driven by collaboration of scientists from within and outside the primary institution. The Center for Magnetic Resonance and Optical Imaging is supported by the National Institute for Biomedical Imaging and Bioengineering through a grant from the National Institutes of Health.

Faculty and Staff

Ravinder Reddy, PhD

Ravinder Reddy, PhD

Director, CMROI

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Penn Radiology Department Chair Mitchell D. Schnall, MD, PhD, FACR

Mitchell D. Schnall, MD, PhD, FACR

Chair, Department of Radiology

Co-Clinical Director, CMROI

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John A. Detre, MD

John A. Detre, MD

Co-Clinical Director, CMROI

Director, Center for Functional Imaging

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Ari Borthakur, PhD, MBA

Associate Director, Training and Dissemination
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Mark Elliott, PhD

Associate Director, Collaboration and Service
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Hari Hariharan, PhD

Associate Director, Technology Transfer
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Susan Colleluori

Associate Director, Fiscal and Administrative
 

Publications

1. Zhou R, Bagga P, Nath K, Hariharan H, Mankoff DA. Reddy R. Glutamate-Weighted Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple-Negative Breast Cancer.  Cancer Res. 2018 Oct 1;78(19):5521-5526. doi: 10.1158/0008-5472.CAN-17-3988. Epub 2018 Aug 2. PMCID: PMC6168340.

2. Nanga RPR, DeBrosse C, Kumar D, Roalf D, McGeehan B, D'Aquilla K, Borthakur A, Hariharan H, Reddy D, Elliott M, Detre JA, Epperson CN, Reddy R. Reproducibility of 2D GluCEST in healthy human volunteers at 7T. Magn Reson Med. 2018 Nov;80(5):2033-2039. doi: 10.1002/mrm.27362. Epub 2018 May 25. PMCID: PMC6107408.

3. Bagga P, Pickup S, Crescenzi R, Martinez D, Borthakur A, D’Aquilla K, Verma G, Detre JA, Greenberg J, Hariharan H, Reddy R. In vivo GluCEST MRI: Reproducibility, background contribution and source of glutamate changes in the MPTP mouse model of Parkinson’s disease. 2018, Scientific Reports 2018 Feb 13;8(1):2883.  PMCID:PMC5811435.

4. Haris M, Bagga P, Hariharan H, McGettigan-Croce B, Johnson LA, Reddy R.  Molecular imaging biomarkers for cell-based immunotherapies. J Transl Med. 2017 Jun 19;15(1):140. doi: 10.1186/s12967-017-1240-6. Review. PMCID: PMC5477274.

5. Bagga P, Haris M, D'Aquilla K, Wilson NE, Marincola FM, Schnall MD, Hariharan H, Reddy, R. Non-caloric sweetener provides magnetic resonance imaging contrast for cancer detection. J Transl Med. 2017 May 30;15(1):119. doi: 10.1186/s12967-017-1221-9.  PMID: 28558795.

 

Contact

Center for Magnetic Resonance & Optical Imaging
Susan Colleluori
422 Curie Boulevard
B1 Stellar Chance Labs
Philadelphia, PA 19104-6100
Phone: 215-898-2932
Email: shannon.long@uphs.upenn.edu

 

Learn more about the Center for Magnetic Resonance and Optical Imaging

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