Description of Research Expertise:
KEY WORDS:
magnetic resonance, brain mapping, cerebral blood flow, brain injury
RESEARCH INTERESTS
Physiology and pathophysiology of functional activation. Clinical and translational neuroimaging. Imaging in stroke. Imaging in epilepsy. Imaging of recovery of function. Imaging in sleep research.
RESEARCH TECHNIQUES
Magnetic resonance imaging and spectroscopy with an emphasis on magnetic resonance techniques used to image brain function in addition to brain structure. Optical spectroscopy and imaging.
RESEARCH SUMMARY
Overall research focuses on cerebral blood flow and metabolism under normal and conditions and in response to brain injury. Specific conditions under investigation include functional activation of human brain in response to cognitive and sensorimotor tasks, epilepsy, cerebrovascular disease, and strokes. This research primarily utilizes magnetic resonance techniques including functional imaging techniques and spectroscopy, often correlated with other methods. There is a large component of data analysis and processing using statistical parametric mapping and other computational methods. In addition, the physiological basis and pathophysiological influences on functional activation are studied using a rat model. The research is carried out in collaboration with investigators from Radiology Research, the Cerebrovascular Research Center, Cognitive Neurology, and the Epilepsy Center.
Selected Publications:
Alsop, D. C., Detre, J. A., Golay, X., Gunther, M., Hendrikse, J., Hernandez-Garcia, L., Lu, H., Macintosh, B. J., Parkes, L. M., Smits, M., van Osch, M. J., Wang, D. J., Wong, E. C., Zaharchuk, G.: Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia Magn Reson Med : 2014.
Wang, Z., Li, Y., Childress, A. R., Detre, J. A.: Brain entropy mapping using fMRI PLoS ONE 9 (3): e89948,2014.
Satterthwaite, T. D., Shinohara, R. T., Wolf, D. H., Hopson, R. D., Elliott, M. A., Vandekar, S. N., Ruparel, K., Calkins, M. E., Roalf, D. R., Gennatas, E. D., Jackson, C., Erus, G., Prabhakaran, K., Davatzikos, C., Detre, J. A., Hakonarson, H., Gur, R. C., Gur, R. E.: Impact of puberty on the evolution of cerebral perfusion during adolescence Proc Natl Acad Sci U S A 111 (23): 8643-8,2014.
Kandel, B.M., Wang, D. J.J., Detre, J.A., Gee, J.C., Avants, B.B.: Decomposing cerebral blood flow MRI into functional and structural components: A non-local approach based on prediction Neuroimage in press : 2014.
Favilla, C. G., Mesquita, R. C., Mullen, M., Durduran, T., Lu, X., Kim, M. N., Minkoff, D. L., Kasner, S. E., Greenberg, J. H., Yodh, A. G., Detre, J. A.: Optical Bedside Monitoring of Cerebral Blood Flow in Acute Ischemic Stroke Patients During Head-of-Bed Manipulation Stroke : 2014.
Franklin, T. R., Wang, Z., Shin, J., Jagannathan, K., Suh, J. J., Detre, J. A., O'Brien, C. P., Childress, A. R.: A VBM study demonstrating ''apparent'' effects of a single dose of medication on T1-weighted MRIs Brain structure & function 218 (1): 97-104,2013.
Weber, M. J., Detre, J. A., Thompson-Schill, S. L., Avants, B. B.: Reproducibility of functional network metrics and network structure: A comparison of task-related BOLD, resting ASL with BOLD contrast, and resting cerebral blood flow Cogn Affect Behav Neurosci : 2013.
Wang, A., Das, S.R., Xie, S.X., Arnold, S.E., Detre, J.A., Wolk, D.A.: Arterial spin labeled MRI in prodromal Alzheimer''s disease: A multi-site study NeuroImage: Clinical 2 : 630-36,2013.
Mesquita, R. C., Schenkel, S. S., Minkoff, D. L., Lu, X., Favilla, C. G., Vora, P. M., Busch, D. R., Chandra, M., Greenberg, J. H., Detre, J. A., Yodh, A. G.: Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions Biomed Opt Express 4 (7): 978-94,2013.
Mesquita, R. C., Faseyitan, O. K., Turkeltaub, P. E., Buckley, E. M., Thomas, A., Kim, M. N., Durduran, T., Greenberg, J. H., Detre, J. A., Yodh, A. G., Hamilton, R. H.: Blood flow and oxygenation changes due to low-frequency repetitive transcranial magnetic stimulation of the cerebral cortex J Biomed Opt 18 (6): 067006,2013.
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