Find a Doctor or Practice Location

Are you a referring physician?
within
I am searching for a
Reset Form
John A. Detre, MD

John A. Detre, MD Physician

Director, Center for Functional Imaging
Professor of Neurology
Professor of Radiology

Dr. Detre is a Penn Medicine employed physician.

Clinical Specialties

Specialty:

  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 1994

Clinical Expertise:

  • Functional Neuroimaging
  • Headache
  • Migraines
  • Stroke

Description of Clinical Expertise

headache, facial pain syndromes, stroke

Practice Locations and Appointments

  • Penn Neurology

    Penn Neuroscience Center Perelman Center for Advanced Medicine, South Pavilion, 2nd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Yale University School of Medicine
Residency: University Health Center of Pittsburgh
Residency: Hospital of the University of Pennsylvania

Memberships

American Academy of Neurology, National American Association for the Advancement of Science (AAAS), National Center for Cognitive Neuroscience (Univ. of Penna.), Local David Mahoney Institute of Neurological Sciences (Univ. of Penna.), Local International Society of Magnetic Resonance in Medicine, International National Headache Foundation, National Philadelphia Neurological Society, Local Society for Neuroscience, National Stroke Council, American Heart Association, National

Hospital Affiliation

Dr. Detre is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

KEY WORDS:
magnetic resonance, brain mapping, cerebral blood flow, brain injury

RESEARCH INTERESTS
Physiology and pathophysiology of functional activation. Clinical and translational neuroimaging. Imaging in stroke. Imaging in epilepsy. Imaging of recovery of function. Imaging in sleep research.


RESEARCH TECHNIQUES
Magnetic resonance imaging and spectroscopy with an emphasis on magnetic resonance techniques used to image brain function in addition to brain structure. Optical spectroscopy and imaging.


RESEARCH SUMMARY
Overall research focuses on cerebral blood flow and metabolism under normal and conditions and in response to brain injury. Specific conditions under investigation include functional activation of human brain in response to cognitive and sensorimotor tasks, epilepsy, cerebrovascular disease, and strokes. This research primarily utilizes magnetic resonance techniques including functional imaging techniques and spectroscopy, often correlated with other methods. There is a large component of data analysis and processing using statistical parametric mapping and other computational methods. In addition, the physiological basis and pathophysiological influences on functional activation are studied using a rat model. The research is carried out in collaboration with investigators from Radiology Research, the Cerebrovascular Research Center, Cognitive Neurology, and the Epilepsy Center.

Selected Publications:

Alsop, D. C., Detre, J. A., Golay, X., Gunther, M., Hendrikse, J., Hernandez-Garcia, L., Lu, H., Macintosh, B. J., Parkes, L. M., Smits, M., van Osch, M. J., Wang, D. J., Wong, E. C., Zaharchuk, G.: Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia Magn Reson Med : 2014.

Wang, Z., Li, Y., Childress, A. R., Detre, J. A.: Brain entropy mapping using fMRI PLoS ONE 9 (3): e89948,2014.

Satterthwaite, T. D., Shinohara, R. T., Wolf, D. H., Hopson, R. D., Elliott, M. A., Vandekar, S. N., Ruparel, K., Calkins, M. E., Roalf, D. R., Gennatas, E. D., Jackson, C., Erus, G., Prabhakaran, K., Davatzikos, C., Detre, J. A., Hakonarson, H., Gur, R. C., Gur, R. E.: Impact of puberty on the evolution of cerebral perfusion during adolescence Proc Natl Acad Sci U S A 111 (23): 8643-8,2014.

Kandel, B.M., Wang, D. J.J., Detre, J.A., Gee, J.C., Avants, B.B.: Decomposing cerebral blood flow MRI into functional and structural components: A non-local approach based on prediction Neuroimage in press : 2014.

Favilla, C. G., Mesquita, R. C., Mullen, M., Durduran, T., Lu, X., Kim, M. N., Minkoff, D. L., Kasner, S. E., Greenberg, J. H., Yodh, A. G., Detre, J. A.: Optical Bedside Monitoring of Cerebral Blood Flow in Acute Ischemic Stroke Patients During Head-of-Bed Manipulation Stroke : 2014.

Wang, A., Das, S.R., Xie, S.X., Arnold, S.E., Detre, J.A., Wolk, D.A.: Arterial spin labeled MRI in prodromal Alzheimer''s disease: A multi-site study NeuroImage: Clinical 2 : 630-36,2013.

Franklin, T. R., Wang, Z., Shin, J., Jagannathan, K., Suh, J. J., Detre, J. A., O'Brien, C. P., Childress, A. R.: A VBM study demonstrating ''apparent'' effects of a single dose of medication on T1-weighted MRIs Brain structure & function 218 (1): 97-104,2013.

Falcone, M., Wileyto, E. P., Ruparel, K., Gerraty, R. T., Laprate, L., Detre, J. A., Gur, R., Loughead, J., Lerman, C.: Age-related differences in working memory deficits during nicotine withdrawal Addict Biol : 2013.

Datta, R., Aguirre, G. K., Hu, S., Detre, J. A., Cucchiara, B.: Interictal cortical hyperresponsiveness in migraine is directly related to the presence of aura Cephalalgia 33 (6): 365-74,2013.

Weber, M. J., Detre, J. A., Thompson-Schill, S. L., Avants, B. B.: Reproducibility of functional network metrics and network structure: A comparison of task-related BOLD, resting ASL with BOLD contrast, and resting cerebral blood flow Cogn Affect Behav Neurosci : 2013.

View all publications

Academic Contact Info

3 W Gates Building
3400 Spruce Street
Office: 517 Goddard Labs

Philadelphia, PA 19104
Phone: (215) 349-8465
Fax: (215) 614-1927
Patient appointments: 800-789-PENN (7366)

Related Links