Department of Radiology

Radiopharmaceutical Chemistry and Biology Lab a-syn Fibrils graphic

Focus

Our program focuses on the development of novel probes for use with the molecular imaging technique, positron emission tomography (PET). 

The Radiopharmaceutical Chemistry and Biology Lab uses basic principles of medicinal chemistry and structural biology in the design and optimization of probes for use in preclinical and translational imaging studies. Current research focuses mostly on radiotracers for imaging PARP-1 expression in tumors ([18F]FTT), cell proliferation and quiescence ([18F]ISO-1) oxidative stress ([18F]ROStrace), dopamine receptor dysregulation, and abnormal protein aggregation in neurodegenerative disorders such as alpha synuclein in Parkinson’s disease.

 

Faculty and Staff

Robert H. Mach, PhD

Robert H. Mach, PhD

Britton Chance Professor of Radiology

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Chenbo Zeng, PhD

Chenbo Zeng, PhD

Research Assistant Professor of Radiology

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Head shot of Mehran Makvandi

Mehran Makvandi, PharmD, RPh, BCNP

Assistant Professor of Radiology at the Hospital of the University of Pennsylvania

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Kuiying Xu, PhD, Research Scientist, Radiopharmaceutical Chemistry and Biology Lab

Kuiying Xu, PhD

Research Scientist
Catherine Hou, Researcher, Radiopharmaceutical Chemistry and Biology Lab

Catherine Hou

Researcher
Chia-Ju Hsieh, MS, Researcher, Radiopharmaceutical Chemistry and Biology Lab

Chia-Ju Hsieh, MS

Researcher
Boeun Lee, PhD, Post Doctoral Fellow, Radiopharmaceutical Chemistry and Biology Lab

Boeun Lee, PhD

Post Doctoral Fellow
Bieneke Janssen, PhD Post Doctoral Fellow, Radiopharmaceutical Chemistry and Biology Lab

Bieneke Janssen, PhD

Post Doctoral Fellow
Aladdin Riad, PhD Post Doctoral Fellow, Radiopharmaceutical Chemistry and Biology Lab

Aladdin Riad, PhD

Post Doctoral Fellow
Zsofia Lengyel, PhD, Post Doctoral Fellow, Radiopharmaceutical Chemistry and Biology Lab

Zsofia Lengyel, PhD

Post Doctoral Fellow
Ji Youn Lee, PhD Post Doctoral Fellow, Radiopharmaceutical Chemistry and Biology Lab

Ji Youn Lee, PhD

Post Doctoral Fellow
Laura Puentes, MS Graduate Student, Radiopharmaceutical Chemistry and Biology Lab

Laura Puentes, MS

Graduate Student
Janet Barrow, Administrative Assistant, Radiopharmaceutical Chemistry and Biology Lab

Janet Barrow

Administrative Coordinator

Recent Publications

1. Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, Simpkins F, Mach RH, Lin LL.  A PET imaging agent for evaluating PARP-1 expression in ovarian cancer.  J Clin Invest. 2018; 2116-2126.

2. Hou C, Hsieh CJ, Li S, Lee H, Graham TJ, Xu K, Weng CC, Doot RK, Chu W, Chakraborty SK, Dugan LL, Mintun MA, Mach RH. Development of a Positron emission tomography radiotracer for imaging elevated levels of superoxide in neuroinflammation. ACS Chem Neurosci. 2018; 9: 578-586. 

3. Hsieh CJ, Ferrie JJ, Xu K, Lee I, Graham TJA, Tu Z, Yu J, Dhavale D, Kotzbauer P, Petersson EJ, Mach RH. Alpha synuclein fibrils contain multiple binding sites for small molecules. ACS Chem Neurosci. 2018; 9: 2521 - 2527.

 

Contact Us

Robert H. Mach, Ph.D.
Britton Chance Professor of Radiology
rmach@pennmedicine.upenn.edu

Janet Barrow
Administrative Coordinator
barrowj@pennmedicine.upenn.edu

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