Our group develops hyperpolarized13C and 129Xe MRI techniques for molecular and functional imaging of a variety of pulmonary disorders. We use hyperpolarized 13C substrates to visualize and quantify alterations in regional metabolic activity in lungs in presence of inflammation and injury in a variety of pathologies including ARDS, COPD, lung allograft rejection, fibrosis as well as in lung cancer. We evaluate the use of this novel molecular imaging tool to detect early changes in disease progression and to investigate its efficacy to monitor response to therapy. We use 129Xe imaging to visualize functional parameters of the lungs including ventilation, oxygen tension and uptake. The combination of our molecular and functional imaging tools paves the way for comprehensive assessment of the pulmonary system for the purpose of diagnosis, phenotyping as well as therapeutic evaluation.
Faculty And Staff
1. Ruppert K, Hamedani H, Amzajerdian F, Xin Y, Duncan IF, Profka H, et al. Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging. Sci Rep 2018;8(1):7310. Doi: 10.1038/s41598-018-25713-0.
2. Pourfathi M, Cereda M, Chatterjee S, Xin Y, Kadlecek S, Duncan I, et al. Lung Metabolism and Inflammation during Mechanical Ventilation; An Imaging Approach. Sci Rep 2018;8(1):3525. Doi: 10.1038/s41598-018-21901-0.
3. Siddiqui S, Kadlecek S, Pourfathi M, et al. The use of hyperpolarized carbon-13 magnetic resonance for molecular imaging. Advanced Drug Delivery Reviews. 2016.
4. Xin Y, Cereda M, Hamedani H, Pourfathi M, Siddiqui S, Meeder N, et al. Unstable Inflation Causing Injury: Insight from Prone Position and Paired CT Scans. Am J Respir Crit Care Med 2018:rccm.201708–1728OC. Doi: 10.1164/rccm.201708-1728OC.
Functional and Metabolic Imaging Group
MRI Learning Center, 1st Floor Founders Building
3400 Spruce Street
Philadelphia, PA 19104