Research images from the Functional and Metabolic Imaging Group (FMIG) at Penn Radiology


Our group develops hyperpolarized13C and 129Xe MRI techniques for molecular and functional imaging of a variety of pulmonary disorders. We use hyperpolarized 13C substrates to visualize and quantify alterations in regional metabolic activity in lungs in presence of inflammation and injury in a variety of pathologies including ARDS, COPD, lung allograft rejection, fibrosis as well as in lung cancer. We evaluate the use of this novel molecular imaging tool to detect early changes in disease progression and to investigate its efficacy to monitor response to therapy. We use 129Xe imaging to visualize functional parameters of the lungs including ventilation, oxygen tension and uptake. The combination of our molecular and functional imaging tools paves the way for comprehensive assessment of the pulmonary system for the purpose of diagnosis, phenotyping as well as therapeutic evaluation.


Faculty And Staff

Rahim R. Rizi, PhD

Rahim R. Rizi, PhD

Professor of Radiology
Primary Investigator

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Stephen J. Kadlecek, PhD

Stephen Kadlecek, PhD

Associate Professor

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Kai Ruppert, PhD

Kai Ruppert, PhD

Research Assistant Professor of Radiology

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Maurizio Cereda, MD

Associate Professor of Radiology

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Federico Sertic

Post-Doctoral Scholar

Faraz Amzajerdian

Graduate Student

Hooman Hamedani

Research Specialist

Mehrdad Pourfathi

Graduate Student

Sarmad Siddiqui

Doctoral Student

Yi Xin

Research Specialist

Tahmina Achekzai

Research Specialist

Ryan Baron

Research Assistant

Ian Duncan

Grant Coordinator

Luis Loza

Research Specialist

Harrilla Profka

Research Specialist

Recent Publications

1. Ruppert K, Hamedani H, Amzajerdian F, Xin Y, Duncan IF, Profka H, et al. Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging. Sci Rep 2018;8(1):7310. Doi: 10.1038/s41598-018-25713-0.

2. Pourfathi M, Cereda M, Chatterjee S, Xin Y, Kadlecek S, Duncan I, et al. Lung Metabolism and Inflammation during Mechanical Ventilation; An Imaging Approach. Sci Rep 2018;8(1):3525. Doi: 10.1038/s41598-018-21901-0.

3. Siddiqui S, Kadlecek S, Pourfathi M, et al. The use of hyperpolarized carbon-13 magnetic resonance for molecular imaging. Advanced Drug Delivery Reviews. 2016.

4. Xin Y, Cereda M, Hamedani H, Pourfathi M, Siddiqui S, Meeder N, et al. Unstable Inflation Causing Injury: Insight from Prone Position and Paired CT Scans. Am J Respir Crit Care Med 2018:rccm.201708–1728OC. Doi: 10.1164/rccm.201708-1728OC.

Contact Us

Functional and Metabolic Imaging Group
MRI Learning Center, 1st Floor Founders Building
3400 Spruce Street
Philadelphia, PA 19104
Phone: 215-662-6671


Learn more about the FMIG

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