Breast cancer detection with four modalities and a single contrast agent
NAMIL focuses on the development of novel and multifunctional nanoparticle contrast agents. A current major area is the development of inorganic (e.g. silver, gold or bismuth) nanoparticles as contrast agents for x-ray based techniques. The nanoparticles can be further modified to have a variety of additional functional properties, such as fluorescence, MRI contrast or therapeutic effects. Related areas of interest are dual energy mammography and photon counting CT. These technologies are being applied for structural imaging and molecular imaging of the levels of specific cell types and proteins in vivo.
Bouché, Mathilde; Hsu, Jessica; Dong, Yuxi C.; Kim, Johoon; Taing, Kimberly; Cormode, David P. Recent advances in molecular imaging with gold nanoparticles. Bioconjugate Chemistry, 2019, online.
Hsu, Jessica, C.; Cruz, Emma D.; Lau, Kristen C.; Bouché, Mathilde; Maidment, Andrew D. A.; Cormode, David P. Renally-excretable and size-tunable silver sulfide nanoparticles for dual energy mammography or computed tomography. Chemistry of Materials, 2019, 31, 19, 7845-7854.
Dong, Yuxi C.; Hajfathalian, Maryam; Maidment, Portia S. N.; Hsu, Jessica C.; Naha, Pratap C.; Si-Mohamed, Salim; Breuilly, Marine; Kim, Johoon; Chhour, Peter; Douek, Philippe; Litt, Harold I.; Cormode, David P. Effect of gold nanoparticle size on their properties as contrast agents for computed tomography. Scientific Reports, 2019, 9, 1, 14912.
Department of Radiology
Smilow Center for Translational Research 11-175
3400 Civic Center Blvd BLDG 421
Philadelphia, PA 19104