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The mission of our NIH-funded Digestives Diseases Research Center is to unite investigators with interests in digestive and liver disease in the exploration of creative experimental approaches as well as to stimulate others to enter these areas of research. The scientific focus of the Center revolves around host-environmental interactions in digestive and liver disease research from bench to bedside. Research amongst Center Investigators includes the molecular regulation of cellular processes in the digestive tract and liver, how they are integrated with the immune system, and their responses to environmental exposures such as diet and the microbiota. The Center is divided into three thematic areas: Intestinal Biology, Liver Biology, and Microbiology/Immunology. Center resources include four scientific cores to support research in both model systems and human subjects for Center Investigators, a pilot project program, weekly seminar series, an annual retreat, and various enrichment programs.

Co-directors

Gary Wu headshotGary D. Wu, MD
Ferdinand G. Weisbrod Professor in Gastroenterology
Director, Host-Microbial Analytic and Repository Core
gdwu@pennmedicine.upenn.edu

Klaus Kaestner headshotKlaus Kaestner, PhD                
Thomas and Evelyn Suor Butterworth Professor of Genetics                   
Director of Next Generation Sequencing Core
kaestner@pennmedicine.upenn.edu

Associate Director

Rebecca Wells headshotRebecca G. Wells, MD
Vice Chief for Research in Gastroenterology and Hepatology
Director of Education, NSF Center for Engineering Mechanobiology
Member, Penn NCI Physical Sciences in Oncology Center PSOC@Penn
Associate Director, NIDDK Center for Molecular Studies in Digestive and Liver Diseases
rgwells@pennmedicine.upenn.edu

Center Administrator

Kim Meyers-McCombs

*Please remember to cite the Center (NIH-P30-DK050306) and its core facilities (Molecular Pathology and Imaging Core, Host-Microbial Analytic and Repository Core, Genetically-Modified Mouse Core, and the Cell Culture and iPS Core) in your publications*

The final report on the NIDDK Centers Program Review has been released and is available on the NIDDK website.  The report includes newly added or revised sections that summarize input and outcomes, including recommendations to enhance the Centers programs.
kimmeyer@pennmedicine.upenn.edu

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