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CRISPR “Minigene” Approach Stops Genetic Liver Disease in Mice

A new CRISPR gene-editing technique prevented a genetic liver disease known to be driven by hundreds of different mutations and improved clinical symptoms in mice, Penn Medicine researchers reported in new proof-of-concept study published online in Science Advances.

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Latest News Releases

Machine Learning Identifies Personalized Brain Networks in Children
February 19, 2020
Results from a new study suggest that Bmal1 gene is not an essential regulator of circadian rhythms
February 18, 2020

On the News Blog

The Curious Case of Preterm Birth: Is Environment to Blame?

February 20, 2020

Perhaps the scariest fact of all is that even in 2020, doctors admit they’re not entirely sure why some babies come early.
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Can You Exercise Your Way Out of Knee Surgery?

February 18, 2020

Between stem cell infusions and exercise, many look to avoid knee replacement surgery. But a Penn Medicine doctor explained that it might not be so easy.
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Helping diabetic women have healthy babies

February 13, 2020

Caitlyn Kristich was thrilled to learn that she was pregnant. She was also scared. Kristich had suffered two miscarriages before she was diagnosed with type 1 diabetes.
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Fractured Body

February 11, 2020

Ram Gajavelli hit the red “STOP” button on the treadmill, ending his walk at just a quarter of a mile because of the stabbing pain he felt in his feet, legs, and back.
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Can Your Birthday Predict Your Future?

February 06, 2020

The Zodiac may not be able to predict your soulmate, but, when it comes to health outcomes, there seems to be some scientific truth behind the astrological musings of the Ancient Greeks. Though it’s likely the environment (of both mother and baby), rather than the stars, that controls your fate.
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Dementia Trends Inspire Innovative Approaches to Care

February 04, 2020

Mary walks toward the hospital, unsteady and confused. Her daughter Susan gently guides her toward the door. As they sit in the waiting room of pre-admission testing, Mary barely hears her name called and doesn’t know what to do when she hears it. Susan helps her to stand and to walk toward a smiling stranger. Mary doesn’t understand the questions the stranger asks.
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Penn Medicine In the News

‘Ditch the Disk’ Group of Tech Execs Is Spurring the Medical Industry to Move on from CD-ROMs
February 16, 2020
CNBC
With Viruses Like Flu and Coronavirus, Pneumonia Often Delivers the Fatal Blow
February 14, 2020
Philadelphia Inquirer
Carl June on CRISPR, CAR T, and How the Vietnam War Dropped Him Into Medicine
February 14, 2020
Endpoints News

Stalling Need for ADT in Recurrent Prostate Cancer
February 14, 2020
MedPage Today
Penn Study Suggests Editing Human Genes to Fight Cancer is Safe
February 12, 2020
Philadelphia Inquirer
Streamline Development Sued for Defective Building
January 31, 2020
WHYY