The following selected publications by Penn authors discuss nicotine dependency and cessation.
Leone FT, Evers-Casey S. Behavioral Interventions in Tobacco Dependence. Prim Care Clin Office Practice 2009, Pages 489–507. A better understanding of the nature of nicotine addiction, of behavioral learning, and of common misconceptions regarding tobacco use treatment, can create new opportunities to impact smoking by offering clinicians novel methods of influence that have otherwise not be available within the traditional cessation approach.
Leone FT, Evers-Casey S. Developing a Rational Approach to Tobacco Use Treatment in Pulmonary Practice: A Review of the Biological Basis of Nicotine Addiction. Clin. Pulm. Med 2012; 19: 53-61. This paper examines the biological basis of this behavior and seeks to integrate this insight into a rational approach to the problem in practice. Smoking is reexamined within the framework of an irrational compulsion to seek nicotine, despite a rational desire to stop. Control over the compulsion to smoke is established as an important clinical outcome, and the rationale for treating tobacco dependence as a chronic illness is examined. Finally, practical insights into managing ambivalence, including an aggressive pharmacotherapeutic approach based on the neurobiology, are presented.
Schnoll RA, Martinez E, Langer C, Miyamoto C, Leone FT. Predictors of Smoking Cessation Among Cancer Patients Enrolled in a Smoking Cessation Program. Acta Oncologica. 2011; 50: 678-684. A discussion of the variables that may influence outcomes of group model cessation interventions.
Schnoll RA, Cappella J, Lerman C, Pinto A, Patterson F, Wileyto EP, Bigman C, Leone FT. A Novel Recruitment Message to Increase Enrollment into a Smoking Cessation Treatment Program: Preliminary Results from a Randomized Trial. J Health Comm. 2011 Jun 10:1-8. Insight into the role of message construction on willingness to engage in cessation treatment.
Schnoll R, Martinez E, Tatum K, Weber D, Kuzla N, Glass M, Ridge J, Langer C, Miyamoto C, Leone FT. A Bupropion Smoking Cessation Clinical Trial for Cancer Patients. Cancer Causes and Control 2010 Jun; 21: 811-820. A report on intervention outcomes in the special case of cancer patients who continue to smoke.
Evers-Casey S , Leone F, Kanzleiter L, Pennsylvania’s Tobacco Education Project- Medical School Module. MedEdPORTAL; 2009. A comprehensive resource for medical educators interested in implementing a tobacco use treatment training module. Includes Standardized Patient scenarios, evaluation materials, and validation data.
Leone FT, Evers-Casey S, Veloski J, Patkar A, Kanzleiter L for the Pennsylvania Continuum of Tobacco Education workgroup. Short, intermediate, and long-term outcomes of Pennsylvania’s Continuum of Tobacco Education Project pilot. Nic Tob Res 2009; 11: 387-393. A report on the educational outcomes derived from implementation of a structured learning experience for third year medical students.
Schnoll RA, Wileyto EP, Pinto A, Leone FT, Gariti P, Siegel S, Perkins K, Dackis C, Berrettini W, Lerman C. A placebo-controlled trial of modafinil for nicotine dependence. Drug Alc Dep. 2008; 98: 86-93. Results from a clinical trial investigating a novel therapeutic target in nicotine dependence.
Niaura R, Hays JT, Jorenby D, Leone FT, Pappas JE, Reeves K, Williams K, Billing C. The efficacy and safety of varenicline for smoking cessation using a flexible dosing strategy in adult smokers. Curr Med Res Opin. 2008; 24: 1931-1941. Results of a clinical trial evaluating the utility of a patient-centered strategy for pharmacologic intervention.
Lazarus SC. Chinchilli VM. Rollings NJ. Boushey HA. Cherniack R. Craig TJ. Deykin A. DiMango E. Fish JE. Ford JG. Israel E. Kiley J. Kraft M. Lemanske RF Jr. Leone FT. Martin RJ. Pesola GR. Peters SP. Sorkness CA. Szefler SJ. Wechsler ME. Fahy JV. National Heart Lung and Blood Institute’s Asthma Clinical Research Network. Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Resp Crit Care Med 2007;175(8):783-90. An analysis of the impact of tobacco smoke exposure on effectiveness of inhaled corticosteroids.