For Nurses and Advanced Practice

The Hospital of the University of Pennsylvania (HUP) was established in 1874 as the nation's first teaching hospital and is one of the nation's premier academic medical centers. As a Magnet® recognized institution, HUP offers nurses the opportunity to practice professional nursing in an environment committed to the highest standards of compassionate patient-centered care, technological advancements, education and clinical research.

Welcome HUP’s Chief Nursing Executive

Colleen Mattioni headshot

Colleen Mattioni, DNP, MBA, RN, CNOR, serves as the Chief Nurse Executive (CNE) at HUP.   In her role, Colleen provides strategic direction and oversight for the delivery of all nursing service at HUP. Dr. Mattioni brings a wealth of relevant experiences and a stellar track record of successes to her new post. As we continue to focus on the new pavilion and the future of HUP, Colleen’s expertise in shaping clinical and operational workflows, acuity adaptable staffing models, and the patient experience will be absolutely essential.

Colleen is known for her collaborative style and proven ability to build strong relationships that span traditional boundaries. Over the past few years, she has worked in partnership with interprofessional colleagues to integrate a number of procedural areas at HUP, moving towards the development of a single standard of care for patients undergoing procedures and preparing us well for the pavilion transition where these services will be co-located.

On the national front, Colleen is recognized as an influential leader in the perioperative space. She consults with hospital leaders across the country sharing evidence-based and best practices for optimizing high reliability leadership and operating room efficiency, implementing ambulatory perioperative care delivery models, and achieving quality and safety outcomes. Colleen is broadly published in peer-reviewed literature and currently serves as a Column Coordinator for the AORN Journal, the indispensable resource for scholarly, evidence-based, peer-reviewed literature for perioperative nursing.

Colleen joined HUP as a staff nurse and assumed positions of progressively responsible nursing leadership over time. She has served on the nursing executive team, initially providing direction for perioperative nursing. After being promoted to Associate Chief Nursing Officer, she expanded her scope to include Women’s Health, Advanced Practice, and the Centers of Nursing Excellence. Colleen was appointed as HUPs Interim CNE in June of last year, and in this capacity, she has truly excelled. Colleen has spearheaded several nursing process innovations to improve the efficiency, quality, and safety of patient care.

Colleen received her Bachelor of Science in Nursing from Villanova University, and subsequently completed a Master’s in Business Administration at Eastern University College of Business. In 2016, she earned a Doctor of Nursing Practice (DNP) from the University of Pittsburgh, School of Nursing. She has completed a fellowship in executive nursing practice through the American Organization of Nurse Leaders.

Nursing Culture

HUP is dedicated to focusing on the needs of patients and their families. HUP's nursing culture delivers high quality, patient-centered care that is influenced by education, experience, and research. Nurses practicing at HUP:

  • Provide high quality, individualized, evidence-based and fiscally responsible nursing care.
  • Are driven by an environment of continuous improvement that is fast paced, high achieving and competitive.
  • Are motivated and encouraged to thrive through accountability, peer evaluation and a shared governance model that empower nurses to have a voice within their practice.
  • Are rewarded for innovation, assertiveness and offering input that contributes to improved patient care.
  • Are "knowledge workers" and professionals who use their specialized knowledge to problem solve and use their unique skills to accomplish their work.

An Innovator in Nursing Practice

HUP possesses one of the leading nursing models of practice in the nation, entitled HUP Nursing Excellence in Professional Practice (HUPNEPP). This visionary model was conceptualized as a means to achieve the highest quality of patient care and facilitate professional growth opportunities for nurses. This multifaceted, innovative model transformed the nursing culture at HUP, empowering nurses to practice world-class patient care through:

Skilled Communication

  • Having a two-way dialogue in which people think and decide together.
  • Having familiar knowledge, united with readiness and dexterity in its application to maintain a healthy work environment..


  • Respectful, collegial communication and behavior.
  • Team orientation.
  • Presence of trust.
  • Respect for diversity.

A Respectful Workplace

To improve the level of professionalism among all HUP staff, the "respectful workplace" values collaborative practice that works to meet the needs of patients by establishing principles and support systems for professional conduct.

A respectful workplace is characterized by understanding, awareness, ownership and the ability to provide feedback to others.

About HUP

The Hospital of the University of Pennsylvania is a 772-bed, world-renowned facility known for its clinical and research excellence. As the nation's oldest medical center and teaching hospital, HUP has pioneered best practices in nursing that have created a culture of excellence for nurses, patients and their families. In 2007, HUP achieved Magnet® recognition, one of the highest honors a hospital can earn in the world of professional nursing. This prestigious honor acknowledges health care organizations for quality patient care, nursing excellence and innovations in professional nursing practice.

A Mission to Continuously Improve the Patient and Family Experience

HUP is on a never-ending journey to improve the patient and family experience. Recently HUP has established a patient family advisory committee. These advisors consist of a volunteer group of current patients, former patients and family members that work with HUP faculty to improve the patient experience. This collaboration works to better serve and enhance the patient experience. These advisors are instrumental in all new programs initiated at HUP.

Nursing Specialties at HUP

At HUP, nurses can grow and excel in the following areas:

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