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Devraj Basu, MD, PhD, FACS

Devraj Basu, MD, PhD, FACS Physician

Associate Professor of Otorhinolaryngology: Head and Neck Surgery at the Hospital of the University of Pennsylvania Associate Professor of Otorhinolaryngology: Head and Neck Surgery at the Hospital of the University of Pennsylvania

Dr. Basu is employed by Penn Medicine.

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About Dr. Devraj Basu

As part of a multidisciplinary team, I am dedicated to optimizing survival for patients with aggressive head and neck cancer cases while managing readily curable ones with the goal of minimizing negative effects of treatment. I have over a decade of experience in managing the most complex head and neck cancer cases as an oncologic and reconstructive surgeon. My NIH-funded research enterprise brings a cutting edge molecular perspective to surgical cancer care while optimizing use of resected tumors to advance the science of cancer therapy. I use open, endoscopic, robotic, and laser procedures to treat both benign and malignant disorders of the mouth, throat, larynx, nose, sinuses, salivary glands, parapharyngeal space, and skin. I am also highly experienced in surgical management of thyroid and parathyroid diseases.

Clinical Specialties

Clinical Expertise:

  • Adenoid Cystic Carcinoma
  • All Cancer Types
  • Angiosarcoma
  • Basal Cell Carcinoma
  • Broken Nose (Nose Fracture)
  • Brow Lift
  • Cancer Surgery
  • Cerebrospinal Fluid (CSF) Leak
  • Chondrosarcoma
  • Craniopharyngioma
  • Dedifferentiated Liposarcoma
  • Deviated Septum
  • Difficulty Swallowing (Dysphagia)
  • Ear and Temporal Bone Cancer
  • Ear and Temporal Bone Tumors
  • Esophageal Cancer
  • Facial Deformities
  • Facial Nerve Disorders
  • Facial Tumors
  • Fat Grafting
  • Fibrosarcoma
  • Flaps Surgery
  • forehead lift
  • Forehead Nodule
  • Glomus Tumor
  • Goiter
  • Head and Neck Tumor
  • Head and Neck Tumor Reconstruction
  • Hoarseness
  • Hypercalcemia
  • Hyperparathyroidism
  • Inverted Papilloma
  • Jaw Deformities
  • Jaw Disorders
  • Jaw Injuries
  • Juvenile Nasopharyngeal Angiofibroma (JNA)
  • Laryngeal Cancer
  • Leiomyosarcoma
  • Lipoma
  • Liposarcoma
  • Malignant Fibrous Histiocytoma
  • Merkel Cell Carcinoma
  • Microsurgery
  • Mouth Cancer (Oral Cancer)
  • Mouth Infections
  • Multiple Endocrine Neoplasia
  • Nasal Cancer
  • Nasal Cavity and Paranasal Sinus Cancer
  • Nasal Polyps
  • Nasopharyngeal Cancer
  • Neck Cancer
  • Neck Masses and Lumps
  • Oncologic Reconstruction
  • Oral Pain
  • Oropharyngeal Cancer
  • Oropharyngeal Disorders
  • Parathyroid Adenoma
  • Radioactive Iodine (Radioiodine) Therapy
  • Rhabdomyosarcoma
  • Salivary Gland Cancer
  • Salivary Gland Disorders
  • Sarcoma
  • Scar Revision
  • Sinonasal Mucocele
  • Sinus Cancer
  • Sinus Disorders
  • Sinus Infections (Sinusitis)
  • Skin Cancer
  • Skin Cancer Reconstructive Surgery
  • Skin Cancer Surgery
  • Skin Grafts
  • Styloidectomy
  • Swallowing Disorders
  • Swollen Lymph Nodes
  • Synovial Sarcoma
  • Throat Cancer
  • Throat Disorders
  • Thyroid Cancer
  • Thyroid Nodule Biopsy
  • Thyroid Nodules
  • Thyroidectomy
  • Tongue Cancer
  • Tonsil Cancer
  • Tonsil Removal Surgery (Tonsillectomy)
  • Tonsillitis (Tonsil Inflammation)
  • Toxic Nodular Goiter
  • Tracheal Cancer
  • TransOral Robotic Surgery (TORS)
  • Vocal Cord Lesion
  • Voice Disorders
  • Zenker's Diverticulum
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Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Washington University
Residency: Barnes-Jewish Hospital - Washington University, St. Louis

Memberships

American Association for the Advancement of Cancer Research, National American College of Surgeons, National American Head and Neck Society, National American Society of Clinical Oncology, National California Tobacco-Related Disease Research Program, National The Triological Society, National

Hospital Affiliation

Dr. Basu is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

As a surgeon-scientist, my overall goal is to improve our ability cure the most aggressive head and neck cancers while also abating treatment toxicity for ones readily curable by existing therapies. My lab's work has pursued how multiple discrete subpopulations of malignant cells within these tumors cooperatively resist therapy via both tumor cell autonomous mechanisms and crosstalk with the stromal microenvironment. In the process, we have developed the ability to analyze heterogeneity and phenotypic plasticity within cancer cell lines, patient-derived xenografts, and primary human cancer samples based on molecular and functional criteria. My group seeks precise molecular definition of the epigenetic plasticity that promotes homeostasis of tumor cells that retain malignant potential in the face of standard therapy. Our studies integrate known drug resistance mechanisms into a conceptual framework where oncogenic signal dependence is regulated by flux between distinct cell states. Our work demonstrates that activation of oncogenic signaling pathways is remarkably heterogeneous and plastic within any single tumor. As a result, rapid compensation to targeting these pathways occurs not only at the level of signaling networks in individual cells but also through dynamics among diverse cell states cooperatively sustaining cancer progression. We are presently exploiting such intra-tumor diversity as a basis to improve the marginal efficacy of current targeted agents in head and neck cancer therapy with new drug combinations.

Selected Publications:

Harmeyer KM, Facompre ND, Herlyn M, Basu D: JARID1 Histone Demethylases: Emerging Targets in Cancer Trends Cancer 3 (10): 713-725,2017.

Facompre ND, Harmeyer KH, Basu D: Regulation of oncogenic PI3-kinase signaling by JARID1B Oncotarget 8 (5): 7218-7219,2017.

Facompre ND, Harmeyer KM, Sole X, Kabraji S, Belden Z, Sahu V, Whelan K, Tanaka K, Weinstein GS, Montone KT, Roesch A, Gimotty PA, Herlyn M, Rustgi AK, Nakagawa H, Ramaswamy S, Basu D: JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers Cancer Res 76 (18): 5538-49,2016.

Facompre ND, Harmeyer KM, Sahu V, Gimotty PA, Rustgi AK, Nakagawa H, Basu D: Targeting JARID1B's Demethylase Activity Blocks a Subset of Its Functions in Oral Cancer Oncotarget 9 (10): 8985-8998,2017.

Facompre ND, Sahu V, Montone KT, Harmeyer KM, Nakagawa H, Rustgi AD, Weinstein GS, Gimotty PA, Basu D: Barriers to Generating PDX Models of HPV-Related Head and Neck Cancer Laryngoscope 127 (12): 2777-2783,2017.

Natsuizaka M, Whelan K, Kagawa S, Tanaka K, Giroux V, Chandramouleeswaran P, Long A, Sahu V, Darling D, Que J, Yang Y, Katz J, Wileyto E, Basu D, Kita Y, Natsugoe S, Naganuma S, Klein-Szanto A, Diehl JA, Bass A, Wong K, Rustgi A, Nakagawa H: Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma Nature Communications 8 (1): 1758,2017.

Basu D, Bewley AF, Sperry SM, Montone KT, Gimotty PA, Rasanen K, Facompre ND, Weinstein GS, Nakagawa H, Diehl JA, Rustgi AK, Herlyn M: EGFR Inhibition Promotes an Aggressive Invasion Pattern Mediated by Mesenchymal-like Tumor Cells within Squamous Cell Carcinomas Mol Cancer Ther 12 (10): 2176-86,2013.

Facompre N, Nakagawa H, Herlyn M, Basu D: Stem-like cells and therapy resistance in squamous cell carcinomas Adv Pharmacol 65 : 235-65,2012.

Basu D, Montone KT, Wang LP, Gimotty PA, Hammond R, Diehl JA, Rustgi AK, Lee JT, Rasanen K, Weinstein GS, Herlyn M: Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas Cell Cycle 10 (12): 2008-16,2011.

Basu D, Ngyen TK, Montone KT, Zhang BS, Wang L, Diehl JA, Rustgi AK, Lee JT, Weinstein GS, Herlyn M: Evidence for mesenchymal-like subpopulations within squamous cell carcinomas possessing chemoresistance and phenotypic plasticity Oncogene 29 (29): 4170-82,2010.

Academic Contact Info

PATIENT APPOINTMENTS: 215-615-3534
RESEARCH LAB WEBSITE: www.basulabupenn.com

Perelman Center for Advanced Medicine
South Pavilion, 3rd Floor
3400 Civic Center Blvd.

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)