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Diagnosis and Treatment of Peripheral Artery Disease

Affecting almost 10 million people, peripheral artery disease (PAD) is a common condition in the United States.

PAD occurs when arteries become narrow or blocked, decreasing blood supply in the legs. It’s caused by a buildup of plaque in the walls of arteries called atherosclerosis. While PAD typically occurs in the legs, it can affect arteries that carry blood from the heart to the kidneys, head, arms or stomach. People with PAD have greater risk for coronary artery disease, heart attack and stroke.

It is a startling statistic that almost 50% of those that are affected by PAD don’t know that they have it and therefore also are unaware of their increased heart and cerebrovascular disease risk. Untreated, PAD can have devastating effects.


Take our PAD Risk Profiler

Signs and Symptoms of PAD

Classic symptoms of PAD typically include pain, fatigue or discomfort in the feet and legs that occurs during walking or exercise and then goes away after a few minutes of rest. Others with the disease may show signs of:

  • Sores on legs or feet that heal slowly or not at all
  • Skin that looks dark and blue
  • Lower temperature in one leg compared to the other
  • Weak or absent pulse in the legs or feet
  • Erectile dysfunction

PAD may be diagnosed following a complete medical history, physical examination and diagnostic tests. One of the most commonly used tests is the ankle-brachial index (ABI), which compares blood pressure in the ankle to blood pressure in the arm. Other studies that could be done to determine where a blood vessel is blocked include ultrasound of arteries, a magnetic resonance angiography test or computed tomography (CAT scan) angiography test.

Illustration of signs and symptoms of peripheral artery disease

Treatment for PAD?

Treatment for PAD is based on severity of the disease, risk factors and test results. Lifestyle changes that can help control PAD include:

  • not smoking
  • eating a healthy diet
  • lowering blood pressure
  • controlling cholesterol
  • exercising regularly – walking at least 30 minutes for three days each week or 10,000 steps per day. Read more about the best workout to manage symptoms of PAD.

Medications to treat underlying conditions may be prescribed, such as statins to lower cholesterol or ACE inhibitor to reduce blood pressure. Surgical procedures such as angioplasty or bypass may also be recommended to open the blocked arteries.

Penn’s Vascular Medicine Program is conducting peripheral artery disease research studies to improve circulation in the legs of patients with PAD.

About this Blog

The Penn Heart and Vascular blog provides the latest information on heart disease prevention, nutrition and breakthroughs in cardiovascular care.


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