Description of Research Expertise

Dr. Choudhri’s research centers on cerebrovascular disease and cutting-edge vascular imaging. He is a recognized leader in cerebrovascular venous imaging, pioneering innovative translational approaches to address conditions such as idiopathic intracranial hypertension and pulsatile tinnitus. His work leverages advanced techniques, including microangiography, optical coherence tomography, photon-counting CT, and state-of-the-art MRI modalities like 4D flow MRI and vessel wall imaging, to deepen our understanding of cerebral venous pathology.

Dr. Choudhri’s lab focuses on cerebrospinal fluid (CSF) physiology, with a particular emphasis on the venous glymphatic system and the molecular mechanisms underlying CSF clearance. His research explores the implications of these processes in diseases such as stroke, multiple sclerosis, and Alzheimer’s disease, as well as their potential for enhancing therapeutic strategies, including drug delivery.

Dedicated to translational science, Dr. Choudhri actively develops and tests novel devices and solutions for cerebrovascular disease. He also leads and collaborates on multiple clinical trials aimed at advancing treatments for aneurysms and venous disorders.

Selected Publications

Musmar B, Adeeb N, Roy JM, Abdalrazeq H, Tjoumakaris SI, Atallah E, Salim HA, Kondziolka D, Sheehan J, Ogilvy CS, Riina H, Kandregula S, Dmytriw AA, El Naamani K, Abdelsalam A, Ironside N, Kumbhare D, Ataoglu C, Essibayi MA, Keles A, Muram S, Sconzo D, Rezai A, Erginoglu U, Pöppe J, Sen RD, Griessenauer CJ, Burkhardt JK, Starke RM, Baskaya MK, Sekhar LN, Levitt MR, Altschul DJ, McAvoy M, Aslan A, Abushehab A, Swaid C, Abla AA, Gooch MR, Rosenwasser RH, Stapleton C, Koch M, Srinivasan VM, Chen PR, Blackburn S, Dannenbaum MJ, Choudhri O, Pukenas B, Orbach D, Smith E, Mosimann PJ, Alaraj A, Aziz-Sultan MA, Patel AB, Cuellar HH, Lawton MT, Morcos J, Guthikonda B, Jabbour P.: Comparing stand-alone endovascular embolization versus stereotactic radiosurgery in the treatment of arteriovenous malformations with Spetzler-Martin grades I-III: a propensity score matched study J Neurointerv Surg : 2024.

Cavarocchi C, Wong K, Cao AC, Hwa TP, Quimby AE, Eliades SJ, Ruckenstein MJ, Bigelow DC, Choudhri OA, Brant JA.: Toward a Diagnostic Imaging Algorithm for Undifferentiated Pulsatile Tinnitus Otol Neurotol 45 : 895-900,2024.

Sarraj A, Hassan AE, Abraham MG, Ortega-Gutierrez S, Kasner SE, Hussain MS, Chen M, Churilov L, Johns H, Sitton CW, Yogendrakumar V, Ng FC, Pujara DK, Blackburn S, Sundararajan S, Hu YC, Herial NA, Arenillas JF, Tsai JP, Budzik RF, Hicks WJ, Kozak O, Yan B, Cordato DJ, Manning NW, Parsons MW, Cheung A, Hanel RA, Aghaebrahim AN, Wu TY, Portela PC, Gandhi CD, Al-Mufti F, Pérez de la Ossa N, Schaafsma JD, Blasco J, Sangha N, Warach S, Kleinig TJ, Shaker F, Al Shaibi F, Toth G, Abdulrazzak MA, Sharma G, Ray A, Sunshine J, Opaskar A, Duncan KR, Xiong W, Samaniego EA, Maali L, Lechtenberg CG, Renú A, Vora N, Nguyen T, Fifi JT, Tjoumakaris SI, Jabbour P, Tsivgoulis G, Pereira VM, Lansberg MG, DeGeorgia M, Sila CA, Bambakidis N, Hill MD, Davis SM, Wechsler L, Grotta JC, Ribo M, Albers GW, Campbell BC; SELECT2 Investigators.: Endovascular Thrombectomy for Large Ischemic Stroke Across Ischemic Injury and Penumbra Profiles JAMA 331 : 750-763,2024.

Sarraj A, Hill MD, Hussain MS, Abraham MG, Ortega-Gutierrez S, Chen M, Kasner SE, Churilov L, Pujara DK, Johns H, Blackburn S, Sundararajan S, Hu YC, Herial NA, Budzik RF, Hicks WJ, Arenillas JF, Tsai JP, Kozak O, Cordato DJ, Hanel RA, Wu TY, Portela PC, Gandhi CD, Al-Mufti F, Maali L, Gibson D, Pérez de la Ossa N, Schaafsma JD, Blasco J, Sangha N, Warach S, Kleinig TJ, Shaker F, Sitton CW, Nguyen T, Fifi JT, Jabbour P, Furlan A, Lansberg MG, Tsivgoulis G, Sila C, Bambakidis N, Davis S, Wechsler L, Albers GW, Grotta JC, Ribo M, Campbell BC, Hassan AE; SELECT2 Investigators; SELECT2 Collaborators; Vora N, Manning NW, Cheung A, Aghaebrahim AN, Paipa Merchán AJ, Sahlein D, Requena Ruiz M, Elijovich L, Arthur A, Al-Shaibi F, Samaniego EA, Duncan KR, Opaskar A, Ray A, Xiong W, Sunshine J, DeGeorgia M, Tjoumakaris S, Mendes Pereira V; SELECT2 Collaborators.: Endovascular Thrombectomy Treatment Effect in Direct vs Transferred Patients With Large Ischemic Strokes: A Prespecified Analysis of the SELECT2 Trial JAMA Neurol 81 : 327-35,2024.

Alkhatib SG, Kandregula S, Flesher K, Choudhri OA, Brant JA, Mohan S.: Imaging of Pulsatile Tinnitus Radiographics : 2024.

Phi HQ, Alkhatib SG, Raymond SB, Choudhri OA, Song JW.: Vessel Wall Imaging in Angiogram-Negative Diffuse Subarachnoid Hemorrhage Reveals a Ruptured Lenticulostriate Aneurysm Neurointervention : 2024.

Tudor T, Sussman J, Sioutas GS, Salem MM, Muhammad N, Romeo D, Corral Tarbay A, Kim Y, Ng J, Rhodes IJ, Gajjar A, Hurst RW, Pukenas B, Bagley L, Choudhri OA, Zager EL, Srinivasan VM, Jankowitz BT, Burkhardt JK.: Intraoperative angiography in neurosurgery: temporal trend, access site, and operative indication considerations from a 6-year institutional experience J Neurointerv Surg : 2023.

Favilla CG, Forti RM, Carter S, Kofke WA, Kasner SE, Baker WB, Yodh AG, Messé SR, Cummings S, Kung DK, Burkhardt JK, Choudhri OA, Pukenas B, Srinivasan VM, Hurst RW, Detre JA.: Microvascular reperfusion during endovascular therapy: the balance of supply and demand J Neurointerv Surg : jnis-2023-020834,2023.

Sioutas GS, Salem MM, Muhammad N, Romeo D, Corral Tarbay A, Kim Y, Sussman J, Ng JJ, Rhodes IJ, Gajjar A, Zager EL, Srinivasan VM, Burkhardt JK, Jankowitz BT, Choudhri OA.: Feasibility and safety of transradial intraoperative angiography for neurosurgery: An institutional experience Interv Neuroradiol : 15910199231196478,2023.

Liu T, Tsui JC, Choudhri OA, Kim BJ, Brucker AJ: Bilateral retinal hemorrhages after sequential endovascular treatment of bilateral unruptured cerebral aneurysms Retin Cases Brief Rep : 2023.

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Academic Contact Information

Perelman Center For Advanced Medicine South Tower
15th Floor, Room 15-146
3400 Civic Center Boulevard
Philadelphia, PA 19104
Phone: 215-662-3487
Patient appointments: 800-789-7366