Description of Research Expertise

Scleroderma and related diseases clinical outcomes, therapeutic interventions and disease pathogenesis. Systemic Lupus Erythematosus clinical outcomes.

Selected Publications

Bean MB, Derk CT: Lower Extremity ulcers in patients with systemic sclerosis Open J Rheumatol Autoimmune Dis 12 (1): 35-45,2022.

Khanna D, Caldron P, Martin RW, Kafaja S, Spiera R, Shahouri S, Shah A, Hsu V, Ervin J, Simms R, Domsic RT, Steen V, Hummers LK, Derk C, Mayes M, Chatterjee S, Varga J, Kesten S, Draser JK, Furst DE: Adipose-derived regenerative cell transplantation for the treatment of hand dysfunction in systemic sclerosis: a randomized clinical trial Arthritis Rheumatol 74 (8): 1399-1408,2022.

GRASP study group: Systemic Sclerosis-associated class II HLA alleles restrict the diversity of the CDR3 and the T cell receptor repertoire in African American patients American College of Rheumatology Annual scientific meeting : 2022.

GRASP study group: Functional NOTCH4 Variants Increase Notch Signaling and susceptibility for systemic sclerosis American College of Rheumatology Annual Scientific meeting : 2022.

GRASP study group: Genome-wide association study in African American systemic sclerosis patients identifies a novel target-transforming growth factor -beta 3 (TGF beta 3) American College of Rheumatology Annual Scientific meeting : 2022.

Minalyan A, Gabrielyan L, Khanal S, Basyal B, Derk CT: Systemic Sclerosis : Current state and survival after lung transplantation Cureus 13 (1): e12797,2021.

Sandorf N, Derk CT, Hajnoczky N: Long term outcomes of vascular grafting of medium sized vessels of the wrist and hand in patients with medication refractory systemic sclerosis related Raynaud's phenomenon at the University of Pennsylvania from 2009-2019 American College of Rheumatology Annual scientific meeting : 2021.

Ingegnoli F, Herrick AL, Schioppo T, Bartoli F, Ughi N, Pauling JD, Sulli A, Cutolo M, Smith V, EULAR study group on microcirculation in rheumatic diseases and the Scleroderma Clinical Trials Consortium: Reporting items for cappilaroscopy in clinical research on musculoskeletal diseases: a systematic review and international Delphi consensus Rheumatology 60 (3): 1410-1418,2021.

Gourth P, Safran SA, Alexander T, Boyden SE, Margan ND, Shah AA, Mayes MD, Doumatey A, Bentley AR, Shriner D, Domsic RT, Medsger TA, Ramos PS, Silver RM, Steen VD, Varga J, Hsu V, Saketkoo LA, Schiopu E, Khanna D, Gordon JK, Kron B, Criswell LA, Gladue H, Derk CT, Bernstein EJ, Bridges SL, Shamugam VK, Kolstad KD, Chung L, Kafaja S, Jan R, Rojanowski M, Goldberg A, Korman BD, Stenbach PJ, Chandrasekharappa SC, Mullikin JC, Adeyemo A, Rotimi C, Wigley FM, Kastner DL, Boin F, Remmers EF: HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry Proc Natl Acad Sci 117 (1): 552-562,2020.

GRASP study group: African ancestry-specific variants regulate TGFbeta3 expression in systemic sclerosis American College of Rheumatology Annual scientific meeting : 2020.

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Academic Contact Information

Division of Rheumatology
300 S Atrium
PCAM Bldg
3400 Spruce street
Philadelphia, PA 19104
Phone: 215-662-2792
Patient appointments: 800-789-7366