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Chris Derk, MD

Chris Derk, MD Physician

Associate Professor of Clinical Medicine

Dr. Derk is employed by Penn Medicine.

About Dr. Chris Derk

Recognized in Philadelphia magazine's annual Top Docs issue for 2017

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties


  • Rheumatology

Programs & Centers:

Board Certification:

  • Rheumatology, 2003

Description of Clinical Expertise

Systemic Sclerosis (Scleroderma) and other fibrotic autoimmune connective tissue disorders ( Eosinophilic Faciitis, Scleromyxedema, Scleredema, Nephrogenic Systemic Fibrosis). Raynaud's phenomenon. Systemic Lupus Erythematosus.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Jefferson Medical College
Residency: Abington Memorial Hospital
Fellowship: Thomas Jefferson University Hospital


American College of Physicians, National American College of Rheumatology, National EULAR Scleroderma Trials and Research group, International Philadelphia Rheumatism Society, Local

Hospital Affiliation

Dr. Derk is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Scleroderma and related diseases clinical outcomes, therapeutic interventions and disease pathogenesis. Systemic Lupus Erythematosus clinical outcomes.

Selected Publications:

A. Schorpion, M. Shenin, R. Neubauer, C.T. Derk: An open-label study of ambrisentan with anti-fibrotic agent combination therapy in the treatment of diffuse systemic sclerosis. EULAR : 2017.

Chung L, Fairchild RM, Furst DE, Li S, Alkassab F, Bolster MB, Csuka ME, Derk CT, Domsick RT, Fischer A, Frech T, Gomberg-Maitland M, Gordon JK, Hitchcliff M, Hsu V, Hummers LK, Khanna D, Medsger TA, Molitor JA, Preston IR, Schiopu E, Shapiro L, Hant F, Silver R, Simms R, Varga J, Steen VD, Zamanian RT: Utility of B-type natriuretic peptides in the assessment of patients with systemic sclerosis-associated pulmonary hypertension in the PHAROS registry Clin Exp Rheumatol : 2016.

Grewal SK, DErk CT, Rosenbach M: Ulcers of the ventral aspect of fingers JAMA Dermatol 152 (10): 1157-58,2016.

Sehra ST, Kelly A, Baker JF, Derk CT: Predictors of inpatient mortality in patients with systemic sclerosis: a case control study Clinical Rheumatology 35 (6): 1631-5,2016.

Khanna D, Denton CP, Merkel PA, Krieg T, Le Brun FO, Marr A, Papadakis K, Pope J, Mattuci-Cerinic M, Furst DE, DUAL-1 investigators, DUAL-2 investigators: Effect of Macitentan on the development of new ischemic digital ulcers in Patients with Systemic Sclerosis: DUAL-1 and DUAL-2 randomized clinical trials. JAMA 315 (18): 1975-88,2016.

Hinchcliff M, Khanna S, Hsu VM, Lee J, Almagor O, Chang RW, Steen V, Chung L, PHAROS investigators: Survival in systemic sclerosis-pulmonary arterial hypertension by serum autoantibody status in the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS) Registry Seminar of Arthritis and Rheumatology 45 (3): 309-14,2015.

Kelly, A; Derk CT: Anti-RNA polymerase III antibodies in Systemic Sclerosis Open Journal of Rheumatology and Autoimmune Diseases 5 : 81-86,2015.

Abraham M, Derk CT: Anti-Ribosomal- P antibodies in lupus nephritis, neuropsychiatric lupus, lupus hepatitis and Chaga's disease: promising yet limited in clinical utility Rheumatol Int 35 (1): 27-33,2015.

Sehra, S; Kelly, A, Baker J, Derk CT: Predictors of inpatient mortality in patient with systemic sclerosis: a case control study American College of Rheumatology, Annual Scientific Meeting, Boston. Poster Presentation : 2014.

Mecoli C, Purohit S, Sandorfi N, Derk CT: Mortality, Recurrence, and hospital course of patients with systemic sclerosis-related acute intestinal pseudo-obstruction J Rheumatol 41 (10): 2049-54,2014.

View all publications

Academic Contact Info

Division of Rheumatology
300 S Atrium
3400 Spruce street

Philadelphia, PA 19104
Phone: (215) 662-2792
Patient appointments: 800-789-7366 (PENN)