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Bryson Katona, MD, PHD

Bryson Katona, MD, PHD Physician

Director, Acute and Transitional Gastroenterology Program Director, Gastrointestinal Cancer Genetics Program Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Katona is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Gastroenterology

Programs & Centers:

Board Certification:

  • Gastroenterology, 2014
  • Internal Medicine, 2012

Clinical Expertise:

  • Cancer Risk Evaluation
  • Colon Polyps
  • Colonoscopy
  • Familial Adenomatous Polyposis (FAP)
  • Gastrointestinal Cancer
  • Gastrointestinal Cancer Genetics
  • Hereditary Diffuse Gastric Cancer (HDGC)
  • Lynch Syndrome
  • MUTYH-Associated Polyposis (MAP)
  • Peutz-Jeghers Syndrome (PJS)
  • Polyposis Syndromes
  • Polyps
  • Upper GI Endoscopy

Description of Clinical Expertise

Hereditary gastrointestinal cancer and polyposis syndromes. Gastrointestinal cancer risk evaluation.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Washington University
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Association for Cancer Research, National American Chemical Society, National American Gastroenterological Association, National Collaborative Group of the Americas on Inherited Colorectal Cancer, National North American Neuroendocrine Tumor Society, National

Hospital Affiliation

Dr. Katona is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Radnor: Has privileges to perform procedures.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Cellular signaling and epigenetic mechanisms of tumorigenesis in colon cancer and gastroenteropancreatic neuroendocrine tumors.

Selected Publications:

Matkar Smita, Sharma Paras, Gao Shubin, Gurung Buddha, Katona Bryson W, Liao Jennifer, Muhammad Abdul Bari, Kong Xiang-Cheng, Wang Lei, Jin Guanghui, Dang Chi V, Hua Xianxin: An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis. Cancer cell 28 (4): 472-85,2015.

Zhu Jiajun, Sammons Morgan A, Donahue Greg, Dou Zhixun, Vedadi Masoud, Getlik Matthäus, Barsyte-Lovejoy Dalia, Al-awar Rima, Katona Bryson W, Shilatifard Ali, Huang Jing, Hua Xianxin, Arrowsmith Cheryl H, Berger Shelley L: Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature 525 (7568): 206-11,2015.

Riff Brian P, Katona Bryson W, Wilkerson Myra, Nathanson Katherine L, Metz David C: HNPCC-associated pheochromocytoma: expanding the tumor spectrum. Pancreas 44 (4): 676-8,2015.

Matkar Smita, Katona Bryson W, Hua Xianxin: Harnessing the hidden antitumor power of the MLL-AF4 oncogene to fight leukemia. Cancer cell 25 (4): 411-3,2014.

Gurung Buddha, Katona Bryson W, Hua Xianxin: Menin-mediated regulation of miRNA biogenesis uncovers the IRS2 pathway as a target for regulating pancreatic beta cells. Oncoscience 1 (9): 562-6,2014.

Katona Bryson W, Liu Yuanyuan, Ma Anqi, Jin Jian, Hua Xianxin: EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon cancer cells. Cancer biology & therapy 15 (12): 1677-87,2014.

Katona Bryson W, Falk Gary W: Barrett's esophagus surveillance: When, how often, does it work? Gastrointestinal endoscopy clinics of North America 21 (1): 9-24,2011.

Katona Bryson W, Anant Shrikant, Covey Douglas F, Stenson William F: Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines. The Journal of biological chemistry 284 (5): 3354-64,2009.

Katona Bryson W, Krishnan Kathiresan, Cai Zu Yun, Manion Brad D, Benz Ann, Taylor Amanda, Evers Alex S, Zorumski Charles F, Mennerick Steven, Covey Douglas F: Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens. European journal of medicinal chemistry 43 (1): 107-13,2008.

Molander Gary A, Katona Bryson W, Machrouhi Fouzia: Development of the suzuki-miyaura cross-coupling reaction: use of air-stable potassium alkynyltrifluoroborates in aryl alkynylations. The Journal of organic chemistry 67 (24): 8416-23,2002.

Li Ping, Bracamontes John, Katona Bryson W, Covey Douglas F, Steinbach Joe Henry, Akk Gustav: Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor. Molecular pharmacology 71 (6): 1582-90,2007.

Katona Bryson W, Rath Nigam P, Anant Shrikant, Stenson William F, Covey Douglas F: Enantiomeric deoxycholic acid: total synthesis, characterization, and preliminary toxicity toward colon cancer cell lines. The Journal of organic chemistry 72 (24): 9298-307,2007.

Katona Bryson W, Cummins Carolyn L, Ferguson Andrew D, Li Tingting, Schmidt Daniel R, Mangelsdorf David J, Covey Douglas F: Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. Journal of medicinal chemistry 50 (24): 6048-58,2007.

View all publications

Academic Contact Info

751 Perelman Center for Advanced Medicine
3400 Civic Center Boulevard
South Pavilion

Philadelphia, PA 19104
Phone: (215) 349-8222
Patient appointments: 800-789-7366 (PENN)