News Release
A digital image with a background of blue cells and a heading in white text that says 2023 American Society of Clinical Oncology Annual Meeting.

CHICAGO –  Researchers from the Abramson Cancer Center and Perelman School of Medicine at the University of Pennsylvania will present data on the latest advances in clinical cancer research at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting from June 2-6 in Chicago, Illinois. Follow us on Twitter @PennMDForum and @PennCancer for updates.

Expert Interviews

Experts from the Perelman School of Medicine are available to comment on a wide range of topics in cancer science and medicine during the meeting on site and by video call, telephone, or email. To arrange interviews, please contact Meagan Raeke at or 267-693-6224.

Incoming ASCO Leaders from Penn Medicine

ASCO President-Elect Lynn M. Schuchter, MD, FASCO, the Madlyn and Leonard Abramson Professor of Clinical Oncology and director of the Tara Miller Melanoma Center, will begin her term as ASCO President for 2023-2024 at the end of the Annual Meeting. Learn more about her election to the top professional society for cancer care.

In addition, Angela DeMichele, MD, MSCE, the Jill & Alan Miller Endowed Chair in Breast Cancer Excellence, will serve as chair of the Scientific Program Committee, and Charu Aggarwal, MD, MPH, the Leslye M. Heisler Associate Professor for Lung Cancer Excellence in Hematology-Oncology, will serve as chair of the Communications Committee for the 2024 ASCO Annual Meeting.

News Releases

Two Penn Medicine Abramson Cancer Center Faculty Members Receive Top ASCO Awards

Real-World Data Suggests Stopping Immunotherapy after Two Years is Reasonable in Patients with Advanced Lung Cancer

Key Presentations

Penn Medicine researchers will present results from clinical trials for recurrent glioblastoma and metastatic HR+/HER2- breast cancer. Experts will also present studies focused on serious illness conversations for patients with cancer, the effect of Medicaid expansion on clinical trial enrollment, and infertility among female oncologists. Key presentations include:

Central Nervous System Tumors

  • Phase II study of immunotherapy with fractionated stereotactic radiotherapy for recurrent glioblastoma (Abstract 2004): In a single-center, multi-arm study involving patients with recurrent glioblastoma, Stephen Bagley, MD, MSCE, an assistant professor of Hematology-Oncology and Neurosurgery, and colleagues, evaluated the immunotherapy drugs retifanlimab (an anti-PD1 agent) and INCAGN01876 (a GITR agonist) in combination with fractionated stereotactic radiotherapy, which was administered as an immunostimulatory strategy. In the cohort of patients who received the immunotherapy drug combination as neoadjuvant therapy prior to surgery, patients who also received neoadjuvant radiotherapy (Cohort B1) experienced a clear overall survival benefit compared to patients who received only neoadjuvant immunotherapy (Cohort B2). Stronger and more sustained inflammatory and cellular immune responses in the peripheral blood were also seen in Cohort B1, supporting preclinical evidence that fractionated stereotactic radiotherapy may help stimulate an anti-tumor immune response. Efficacy of the treatment regimen was not observed in Cohort B2 or the other group of patients whose treatment plans did not include surgery (Cohort A). Bagley will present the findings in an oral abstract session on Friday, June 2, at 2:45 p.m. CT in S100a.

Breast Cancer

  • BRACELET-1 (PrE0113), a Phase II study of oncolytic reovirus for metastatic HR+/HER2- breast cancer (Abstract 1012): This multicenter clinical trial enrolled 48 patients with HR+/HER2- metastatic breast cancer who were randomized to receive either chemotherapy alone (Cohort 1), chemotherapy in combination with pelareorep, an oncolytic reovirus engineered to attack cancer cells (Cohort 2), or both treatments with the addition of the immunotherapy avelumab (Cohort 3). As the trial co-PI and Penn Medicine site PI Amy Clark, MD, an assistant professor of Hematology-Oncology, and colleagues, found, the early data indicates chemotherapy plus pelareorep has a higher response rate and 6-month progression-free survival compared to chemotherapy alone, and pelareorep increased T-cell responses in blood samples. One third of patients discontinued either pelareorep or avelumab due to adverse side effects from treatment. Clark will present the results during The Dr. Bernard Fisher Memorial Annual Clinical Science Symposium on Saturday, June 3, at 1:15 p.m. CT in S406.

Equity in Oncology

  • Survey on infertility and elective fertility preservation in female oncologists and trainees (Abstract 11001): Emily MacDuffie, MD, a Radiation Oncology resident, and colleagues, designed a survey to learn more about attitudes toward family planning and use of assisted reproductive technology among self-identified United States female oncologists of all career levels. Medical training often coincides with peak fertility years, and female physicians are known to have higher rates of infertility than the general population. Of 1,005 female oncologists surveyed, one-third (32%) reported experiencing infertility. Among those who experienced infertility, 39% reported out-of-pockets costs of $10,000 or more for assisted reproductive technology. About three-quarters of female attending physicians (76%) and trainees (72%) who were interested in future fertility preservation were unsure of the feasibility to do so. MacDuffie will present the results in a clinical science symposium session on Saturday, June 3 at 4:30 p.m. CT in S100a.

Health Services Research, Quality Improvement, Care Delivery and Regulatory Policy

  • End-of-life spending analysis from serious illness communication nudge study (Abstract 6515): This secondary analysis follows the results of randomized clinical trial, published in JAMA Oncology in January, that found machine learning-triggered nudges to prompt serious illness communication among patients with cancer improved end-of-life care. In this follow-up, lead author Ravi B. Parikh, MD, an assistant professor of Medical Ethics and Health Policy and Medicine, and colleagues, found that the intervention also resulted in lower spending on care in the last 180 days of life, driven primarily by lower spending on chemotherapy, outpatient care, and other therapies. Parikh will present the results during a poster discussion session on Saturday, June 3 at 4:30 p.m. CT in E350.
  • Patient- and clinician-directed strategies to improve serious illness communication (Abstract 1514): Following the above nudge model to prompt serious illness conversations, this randomized clinical trial added another layer: a patient-facing message sent electronically before a clinic visit, with a three-question survey designed to prime patients for a serious illness conversation with their oncology team. In a study that enrolled 4,450 patients with cancer, Samuel Takvorian, MD, MS, an assistant professor of Hematology-Oncology, and colleagues, found that when both patients and physicians received a nudge, serious illness conversations were more likely to take place, compared to a control group or only one party receiving the nudge. Takvorian will present the results during a poster discussion session on Monday, June 5 at 4:30 p.m. CT in S102.
  • Medicaid expansion and accrual of Black and Hispanic patients to cancer clinical trials (Abstract 1510): Using anonymous data from 75,700 participants across 1,409 clinical trials and 351 sites, Takvorian and colleagues compared clinical trial demographics in states that did and did not expand Medicaid eligibility under the Affordable Care Act to determine if the expansion increased the percentage of Black and Hispanic patients enrolled in oncology clinical trials. Although Medicaid expansion alone did not make a statistically significant impact, in states that mandated Medicaid cover the routine costs of trial participation, Black and/or Hispanic participant enrollment significantly increased. Takvorian will present the results during a poster discussion session on Monday, June 5 at 4:30 p.m. CT in S102.


Penn Medicine is one of the world’s leading academic medical centers, dedicated to the related missions of medical education, biomedical research, excellence in patient care, and community service. The organization consists of the University of Pennsylvania Health System and Penn’s Raymond and Ruth Perelman School of Medicine, founded in 1765 as the nation’s first medical school.

The Perelman School of Medicine is consistently among the nation's top recipients of funding from the National Institutes of Health, with $550 million awarded in the 2022 fiscal year. Home to a proud history of “firsts” in medicine, Penn Medicine teams have pioneered discoveries and innovations that have shaped modern medicine, including recent breakthroughs such as CAR T cell therapy for cancer and the mRNA technology used in COVID-19 vaccines.

The University of Pennsylvania Health System’s patient care facilities stretch from the Susquehanna River in Pennsylvania to the New Jersey shore. These include the Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, Chester County Hospital, Lancaster General Health, Penn Medicine Princeton Health, and Pennsylvania Hospital—the nation’s first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.

Penn Medicine is an $11.1 billion enterprise powered by more than 49,000 talented faculty and staff.

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