News Release


PHILADELPHIA— While the technology for developing artificial intelligence-powered chatbots has existed for some time, a new viewpoint piece in JAMA lays out the clinical, ethical, and legal aspects that must be considered before applying them in healthcare. And while the emergence of COVID-19 and the social distancing that accompanies it has prompted more health systems to explore and apply automated chatbots, the authors still urge caution and thoughtfulness before proceeding.

“We need to recognize that this is relatively new technology and even for the older systems that were in place, the data are limited,” said the viewpoint’s lead author, John D. McGreevey III, MD, an associate professor of Medicine in the Perelman School of Medicine at the University of Pennsylvania. “Any efforts also need to realize that much of the data we have comes from research, not widespread clinical implementation. Knowing that, evaluation of these systems must be robust when they enter the clinical space, and those operating them should be nimble enough to adapt quickly to feedback.”

McGreevey, joined by C. William Hanson III, MD, chief medical information officer at Penn Medicine, and Ross Koppel, PhD, FACMI, a senior fellow at the Leonard Davis Institute of Healthcare Economics at Penn and professor of Medical Informatics, wrote “Clinical, Legal, and Ethical Aspects of AI-Assisted Conversational Agents.” In it, the authors lay out 12 different focus areas that should be considered when planning to implement a chatbot, or, more formally, “conversational agent,” in clinical care.

Chatbots are a tool used to communicate with patients via text message or voice. Many chatbots are powered by artificial intelligence (AI). This paper specifically discusses chatbots that use natural language processing, an AI process that seeks to “understand” language used in conversationsand draws threads and connections from them to provide meaningful and useful answers.

With health care, those messages, and people’s reactions to them, are extremely important and carry tangible consequences.

“We are increasingly in direct communication with our patients through electronic medical records, giving them direct access to their test results, diagnoses and doctors’ notes,” Hanson said. “Chatbots have the ability to enhance the value of those communications on the one hand, or cause confusion or even harm, on the other.”

For instance, how a chatbot handles someone telling it something as serious as “I want to hurt myself” has many different implications.

In the self-harm example, there are several areas of focus laid out by the authors that apply. This touches first and foremost on the “Patient Safety” category: Who monitors the chatbot and how often do they do it? It also touches on “Trust and Transparency”: Would this patient actually take a response from a known chatbot seriously? It also, unfortunately, raises questions in the paper’s “Legal & Licensing” category: Who is accountable if the chatbot fails in its task. Moreover, a question under the “Scope” category may apply here, too: Is this a task best suited for a chatbot, or is it something that should still be totally human-operated?

Within their viewpoint, the team believes they have laid out key considerations that can inform a framework for decision-making when it comes to implementing chatbots in health care. Their considerations should apply even when rapid implementation is required to respond to events like the spread of COVID-19.

“To what extent should chatbots be extending the capabilities of clinicians, which we’d call augmented intelligence, or replacing them through totally artificial intelligence?” Koppel said. “Likewise, we need to determine the limits of chatbot authority to perform in different clinical scenarios, such as when a patient indicates that they have a cough, should the chatbot only respond by letting a nurse know or digging in further: ‘Can you tell me more about your cough?’”

Chatbots have the opportunity to significantly improve health outcomes and lower health systems’ operating costs, but evaluation and research will be key to that: both to ensure smooth operation and to keep the trust of both patients and health care workers.

“It’s our belief that the work is not done when the conversational agent is deployed,” McGreevey said. “These are going to be increasingly impactful technologies that deserve to be monitored not just before they are launched, but continuously throughout the life cycle of their work with patients.”


Penn Medicine is one of the world’s leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation’s first medical school) and the University of Pennsylvania Health System, which together form a $8.6 billion enterprise.

The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $494 million awarded in the 2019 fiscal year.

The University of Pennsylvania Health System’s patient care facilities include: the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center—which are recognized as one of the nation’s top “Honor Roll” hospitals by U.S. News & World Report—Chester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; and Pennsylvania Hospital, the nation’s first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.

Penn Medicine is powered by a talented and dedicated workforce of more than 43,900 people. The organization also has alliances with top community health systems across both Southeastern Pennsylvania and Southern New Jersey, creating more options for patients no matter where they live.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2019, Penn Medicine provided more than $583 million to benefit our community.

Share This Page: