News Release

PHILADELPHIA – Penn Medicine will break ground Friday on a state-of-the-art, four-story, 250,000-square-foot multispecialty outpatient facility in Radnor, Pa., that will expand options for patients to receive advanced care close to home.

Set to open in Spring 2020, the site will be home to the new Penn Medicine Radnor, replacing its current facility in the Township which has operated since 1997 on King of Prussia Road. The new location will provide comprehensive cancer care, including newly available radiation oncology services and chemotherapy provided by the Abramson Cancer Center, as well as primary care, heart and vascular, orthopaedic and neuroscience care. Additional services will include same-day surgery, with six operating rooms and four endoscopy suites, along with full radiology and laboratory services. Patients will also have access to cutting-edge Penn Medicine clinical trials, expanding access to more patients without having to travel into Philadelphia.

Officials will also announce today that Brandywine Realty Trust has entered into an agreement with University of Pennsylvania Health System to purchase and serve as the designated developer and manager of two premier sites in Radnor where the new outpatient facility will take shape (145 King of Prussia Rd. and 250 King of Prussia Rd.). Brandywine will transform the new buildings into high-quality facilities – including office space and a hotel – and will serve as the development manager of the medical office building, allowing Penn to expand its network and offer even more locations to deliver the level of care for which the health system is renowned.

The new LEED Silver certified building will feature natural light throughout, and a building design which wraps around a courtyard will bring nature views to patients, families, and staff inside.

“More than half of our activity comes from outpatient care today, and we’re committed to investing in the very best facilities which can offer our patients more options to get the best possible care close to their homes,” said Ralph W. Muller, CEO of the University of Pennsylvania Health System. “Our mission is to offer Penn Medicine care to patients where it’s most convenient to them and their families, so we’re making more cancer, women’s health, and cardiac services available to patients at Radnor to ensure they can receive a more comprehensive suite of care without having to travel downtown.”

The western section of 145 King of Prussia Road will introduce 150,000 GSF of office space and a hotel component comprising 75,000 GSF, with a projected 100 rooms – which Penn Medicine officials say will help make the new Radnor facility a destination for patients traveling for specialized outpatient services from outside the area. The eastern portion of 145 King of Prussia Road will serve as a medical office parcel.

The University of Pennsylvania has been a long-time, valued partner of ours, and together we have created transformative projects that have helped to shape the city of Philadelphia that we know today, most notably FMC Tower at Cira Centre South,” said Jerry Sweeney, President and CEO of Brandywine Realty Trust. “As Penn Medicine continues to expand its footprint, we are proud to work alongside them to bring new, high-quality offerings to their patients and help fuel the great work that they continue to deliver.”   

“We are excited for our partnership with Brandywine, which will develop this area of Radnor into a state-of-the-art mixed-use campus that will build on Penn Medicine’s longstanding support of health and wellness for residents of the Township and beyond,” said Kevin B. Mahoney, executive vice president and chief administrative officer for the University of Pennsylvania Health System.

The new Radnor facility, which is double the square footage of the current Penn Medicine Radnor building, is the latest among a growing list of Penn Medicine multispecialty ambulatory centers. Other sites include the Perelman Center for Advanced Medicine, Penn Medicine University City and Washington Square in Philadelphia, as well as facilities in Bucks County, Valley Forge, Southern Chester County (West Grove) and, in Southern New Jersey, Cherry Hill and Woodbury Heights.


Penn Medicine is one of the world’s leading academic medical centers, dedicated to the related missions of medical education, biomedical research, excellence in patient care, and community service. The organization consists of the University of Pennsylvania Health System and Penn’s Raymond and Ruth Perelman School of Medicine, founded in 1765 as the nation’s first medical school.

The Perelman School of Medicine is consistently among the nation's top recipients of funding from the National Institutes of Health, with $550 million awarded in the 2022 fiscal year. Home to a proud history of “firsts” in medicine, Penn Medicine teams have pioneered discoveries and innovations that have shaped modern medicine, including recent breakthroughs such as CAR T cell therapy for cancer and the mRNA technology used in COVID-19 vaccines.

The University of Pennsylvania Health System’s patient care facilities stretch from the Susquehanna River in Pennsylvania to the New Jersey shore. These include the Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, Chester County Hospital, Lancaster General Health, Penn Medicine Princeton Health, and Pennsylvania Hospital—the nation’s first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.

Penn Medicine is an $11.1 billion enterprise powered by more than 49,000 talented faculty and staff.

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