PHILADELPHIA — Mark L. Kahn, MD, professor of Medicine, Perelman School of Medicine at the University of Pennsylvania, received a five-year, $6 million grant from Paris-based Fondation Leducq to study lymphatic vascular defects and their contribution to common human cardiovascular diseases. Kahn and his lab team, including Zhiying Zou, Paul Hess, Zoltan Jakus, and Patty Mericko, lead the North American contingent of an international group that includes two other American and three European academic institutions.

The lymphatic vascular system comprises a large vascular network that regulates fluid balance, transports fats and coordinates immune responses in the body. The lymphatic system is poorly understood compared to the blood vascular system and its role in human vascular diseases is relatively unexplored. The project brings together the major labs investigating lymphatic vascular biology to understand the impact of lymphatic dysfunction on cardiovascular disease and to develop new therapies for lymphatic vascular diseases.

For more information please read the Fondation Leducq news release:


Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $5.3 billion enterprise.

The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 18 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $373 million awarded in the 2015 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center -- which are recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report -- Chester County Hospital; Lancaster General Health; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Chestnut Hill Hospital and Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2015, Penn Medicine provided $253.3 million to benefit our community.

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