What is osteoarthritis? 

Osteoarthritis (OA), also called degenerative arthritis, is the most common type of arthritis. It happens when the cartilage that cushions the ends of your bones wears down over time. Without enough cartilage, bones rub against each other, causing pain, stiffness, and swelling. OA can affect any joint but is most common in the knees, hips, hands, and spine. Symptoms often develop gradually and worsen as the condition progresses.

Penn Medicine provides comprehensive, innovative care for people with osteoarthritis. We are your trusted partner in managing this condition to minimize pain and maximize mobility at every stage.

Symptoms of osteoarthritis

Osteoarthritis symptoms can vary from person to person and often develop slowly. Common signs include:

  • Joint pain that worsens with activity and improves with rest
  • Stiffness, especially after waking up or sitting still for long periods
  • Tenderness when pressing on the joint
  • Swelling caused by fluid or bone growths (bone spurs)
  • A rubbing, crackling, or grating sound (crepitation) when moving the joint
  • Limited range of motion
  • Pain that may become constant or disturb sleep as OA progresses

While OA most often affects weight-bearing joints, over time it can impact daily activities such as walking, climbing stairs, or even sleeping comfortably.

What causes osteoarthritis? 

OA develops when joint cartilage gradually breaks down, but several risk factors can increase the likelihood of the disease:

  • Age: Wear and tear makes OA more common as you get older.
  • Sex: People assigned female at birth have a higher risk of developing osteoarthritis over age 55.
  • Genetics: OA often runs in families.
  • Excess weight: Extra pounds increase stress on hips, knees, ankles, and feet.
  • Injury: Previous fractures, ligament tears, or cartilage injuries may trigger OA years later.
  • Occupation and sports: Jobs or sports that involve heavy lifting, kneeling, squatting, or twisting put joints at risk.
  • Other conditions: Autoimmune diseases like rheumatoid arthritis can weaken joints and increase the risk of osteoarthritis.

Diagnosing osteoarthritis

Your provider will ask about your medical history, review your symptoms, perform a physical exam, and order imaging tests to view your joints and surrounding tissues. Joint fluid analysis or blood tests may be performed to rule out infection or other causes of pain and inflammation.

CT scan
A CT scan helps diagnose traumatic injuries, cancer, vascular diseases, and many other conditions.
MRI
An MRI provides high-resolution images of the brain, spine, and many other structures in the body.
Ultrasound
Leading-edge ultrasound technology helps us diagnose a range of health conditions.
X-ray
We use X-rays to diagnose broken bones, lung problems, and many other conditions.

Osteoarthritis treatment and management options

While there’s no cure for osteoarthritis, treatment can relieve pain, improve mobility, and slow progression. Care may include lifestyle changes such as weight management, exercise, and joint protection strategies. Over-the-counter medications, including oral pain relievers and topical creams or gels, can ease discomfort and support daily movement. Prescription medicines may be used for chronic symptoms, and corticosteroid injections can provide short-term relief. Physical therapy helps strengthen muscles and improve joint motion. Braces or splints may be recommended to support weak joints and redistribute weight. Some people also benefit from alternative approaches, such as acupuncture, yoga, or tai chi.

Penn Medicine also offers a wide range of innovative therapies for osteoarthritis, including low-dose radiation, a nonsurgical alternative that involves six sessions over three weeks to relieve OA inflammation in the knees, hips, ankles, elbows, hands, wrists, and shoulders. When surgery is your best option, Penn Medicine’s orthopaedic experts perform advanced procedures like minimally invasive and robot-assisted surgery.

Arthritis surgery
This surgical procedure is used to fix or replace damaged joints caused by arthritis.
Arthroscopy
This minimally invasive procedure uses an arthroscope to view the inside of a joint and make repairs.
Platelet-rich plasma (PRP) injections
This treatment uses a patient’s platelets to promote healing for sports injuries and other conditions.

Leaders in osteoarthritis and bone health

Penn Medicine offers high-quality, comprehensive care for every stage of osteoarthritis, including the latest surgical and nonsurgical treatments based on active research and clinical trials. You’ll benefit from personalized rehabilitation plans, advanced pain management, and access to multiple specialists, often available within the same location.

Related specialties

Arthritis care
We deliver complete care for the many forms of arthritis, all within one trusted health system.
Elbow pain
Our experts address a wide range of injuries and functional issues affecting the elbow.
Hip pain
We offer advanced nonsurgical and surgical solutions to bring pain relief and restore function to hips.
Holistic therapies
Discover holistic therapies like massage and acupuncture to ease pain, reduce stress, and boost wellness.
Joint replacement
Our innovative, collaborative care is the best approach for those seeking a joint replacement.
Knee pain
We have the technology and expertise to evaluate and treat a full range of knee issues, from minor to complex.

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