Gestational trophoblastic disease treatment

At Penn Medicine, we take a precision medicine approach to determine the best treatment plan for your unique medical history. Our gynecologic oncologists will communicate regularly with other Penn specialists and members of your care team to provide comprehensive, integrated care. And we are experienced in creating fertility-sparing treatment plans when current or future pregnancy is a consideration.

Learn more about Penn Medicine’s fertility preservation program

Gestational trophoblastic disease treatments at Penn Medicine

Although most cases of gestational trophoblastic disease (GTD) are benign (not cancer) tumors, Penn doctors will follow up for six months after treatment to see if the growth has returned or become cancerous.

Treatment for GTD depends on:

  • Age
  • Type of GTD
  • If the tumor has spread
  • The number, location, and size of tumors in the body
  • Blood level of beta human chorionic gonadotropin (β-hCG), a hormone that the body makes during pregnancy
  • How soon the tumor was diagnosed after the pregnancy began
  • If GTD occurred after a molar pregnancy, miscarriage, or normal pregnancy
  • Previous treatment for GTD

Gestational trophoblastic disease chemotherapy

Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Chemotherapy may be given before or after surgery, or on its own as a treatment for gestational trophoblastic neoplasia.

The chemotherapy type and delivery method depends on the type and stage of the cancer being treated:

  • Combination therapy is treatment with more than one anticancer drug.
  • Neoadjuvant therapy is given before surgery to shrink a tumor in order to more easily remove it.
  • Systemic chemotherapy is taken by mouth or injected into a vein or muscle. It then enters the bloodstream to reach cancer cells throughout the body.
  • Regional chemotherapy is placed directly into the cerebrospinal fluid, an organ, or a body cavity (such as the abdomen), to treat cancer in those areas.
  • Intraperitoneal (IP) chemotherapy is delivered directly into the peritoneal cavity (the space that contains the abdominal organs) through a thin tube.

Gestational trophoblastic disease surgery

At Penn Medicine, our minimally invasive techniques, such as robotic-assisted surgery, have become the standard of care for treating gynecologic cancers. If you have surgery for gestational trophoblastic disease (GTD), your doctors will follow up with regular blood tests to measure your levels of beta-HCG, a hormone that can be a sign of GTD.

Two types of surgery are most often used to treat GTD:

Gestational trophoblastic disease radiation

Radiation therapy, which uses high-energy X-rays to kill cancer cells, is generally not used to treat GTD except in special circumstances. For example, radiation may be used in certain cases to treat cancer that has spread to other parts of the body.

For those cases in which radiation therapy is used, Penn Radiation Oncology has the most advanced equipment and technology available to treat cancer. Our radiation oncologists are recognized leaders in using techniques that target radiation precisely to the treatment area while sparing normal tissue.

Gestational trophoblastic disease support services

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