Director: Eline Luning Prak, MD, PhD
The Human Immunology Core provides state-of-the-art immune assays, cellular products and immunological expertise for clinical trials and immunology research. Immunological data generated by the Core are used to evaluate and improve novel cancer therapies. The Core also provides specimens and reagents to facilitate basic and translational research that enhances our understanding of the tumor microenvironment and the host immune response.
The Core performs a wide range of cellular immunology assays including cell proliferation assays, multifunctional lymphocyte subset analysis by flow cytometry, luminex, and assays that measure lymphocyte activation and specificity, including ELISPOT and intracellular cytokine profiling. Under Dr. Luning Prak's leadership, the Core has expanded its services in molecular immunology and high complexity data analysis, and now performs high throughput sequencing, cloning and analysis of antibody gene rearrangements, with TCR assays in the pipeline. Services also include the provision of purified primary human blood cell subsets from apheresis donors, and annotated specimen handling and storage. The Core staff works closely with each investigator to perform the optimal immunological assays and sample processing for each research study and clinical trial. The Core can perform studies on a pilot research basis, or at the standard of Good Laboratory Practices, as needed.
Eline Luning Prak, MD, PhD
For more information, please visit the Core's website: https://pathbio.med.upenn.edu/hic/site/