Knee pain

Knee pain can have a profound impact on your activities, leaving you on the sidelines of daily life. Trust the orthopaedic experts at Penn Medicine to help you get back to living a life you love.
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When pain brings you to your knees, we bring solutions

You may not realize just how much you rely on your knees until pain strikes. There are lots of possible reasons why your knee may be bothering you. From injury to arthritis, many conditions can cause discomfort, swelling, or stiffness.

At Penn Orthopaedics, our experts conduct a thorough evaluation using advanced imaging to determine the cause of your knee pain and help you understand your best options for finding relief. Whether your knee condition is common or complex, we take an evidence-based approach to determining the best way forward for you.

Clinical trials

Clinical trials offer patients the opportunity to try new and effective treatments and take part in future research.

Find a clinical trial

Second opinions

If you've received a diagnosis, our team of experts offers second opinions to grant you peace of mind.

Schedule a second opinion

Comprehensive knee pain treatment options

Our team prioritizes conservative nonsurgical knee treatment approaches whenever possible to manage knee pain. For patients requiring surgical knee interventions, Penn Orthopaedics provides state-of-the-art procedures and a dedicated rehabilitation program for optimal recovery. Our renowned joint replacement surgeons are well-versed in the most advanced knee reconstruction techniques and work with specialists across the health system to ensure seamless care.

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Knee surgery

Our orthopaedic surgeons are leaders in research, compassionate care, and simple to complex knee procedures.

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Nonsurgical treatments for knee pain

Our experts provide noninvasive relief to delay, prevent, or complement knee surgery.

Elderly woman patient show her scars surgical total knee joint replacement Suture wound surgery arthroplasty on bed in hospital.

Joint replacement

Our innovative, collaborative care is the best approach for those seeking a joint replacement.

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Trauma and fracture care

We treat all musculoskeletal fractures, traumatic injuries, and related complications.

Conditions we treat

  • Anterior cruciate ligament (ACL) injury
  • Arthritis
  • Bursitis
  • Gout
  • Lateral collateral ligament (LCL) injury
  • Medial collateral ligament (MCL) injury
  • Meniscus tear
  • Osteoarthritis
  • Osteonecrosis
  • Posterior cruciate ligament (PCL) injury
  • Rheumatoid arthritis
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Advanced sports medicine

Healthy knees provide stability, support, and mobility for running, jumping, and pivoting while absorbing impact and bearing weight. Sports medicine addresses activity-related injuries that often involve the knee, focusing on performance and prevention. Our sports medicine providers deliver advanced, end-to-end care, from diagnosis to recovery, combining the latest technology with personalized care to get you moving again.

  • Sports medicine
  • Cartilage Center
  • Regenerative medicine and orthobiologics
  • Center for the Female Athlete
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Orthopaedic oncology

Orthopaedic oncologists treat bone and soft tissue tumors, especially in the arms, legs, and pelvis. If you need a diagnosis or second opinion, our experienced team offers personalized treatment plans to remove tumors and preserve or restore mobility.

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Our doctors

Our providers work with you to plan and deliver exceptional treatment and personalized care.

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Locations

Our hospitals, multispecialty medical centers, pharmacies, labs and more offer outstanding, personalized care for patients all across the region.

Related articles

Meniscus injuries may soon be treated by customizable hydrogel

A new 3D-printed customizable hydrogel performed well in preclinical trials with several different types of meniscal tears.

  • March 25, 2025

Knee cartilage degeneration halted by new treatment target

With no cure for osteoarthritis, scientists believe they’ve discovered a method through which a simple knee injection could potentially stop it.

  • January 14, 2021

Patient stories

Karen's quick discharge accelerates knee surgery recovery

Karen's quick discharge accelerates knee surgery recovery

“Dr. Lyons and his staff were very responsive in addressing my questions. And my physical therapist knew just when to push me and when it was enough. I was very impressed with everyone. I don’t have a single complaint about the entire process, from scheduling the surgery and the pre-op testing to the physical therapy at home and follow-up exams.”

Preschool teacher's journey to pain-free living

Preschool teacher's journey to pain-free living

“Three days after my hip surgery, I didn’t need a walker. And I was like, ‘Wait, this is it?’ There wasn’t much swelling or pain.”

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