PMOS care

Polyendocrine metabolic ovarian syndrome (PMOS) is a lifelong condition affecting menstrual cycles, fertility, cardiometabolic health, and mental health. Penn Medicine’s specialists provide comprehensive care and the latest, most effective treatments.
Female doctor holds a digital tablet while listening attentively to the unrecognizable female patient

Personalized treatment by compassionate PMOS specialists

Polyendocrine metabolic ovarian syndrome (PMOS), formerly referred to as polycystic ovary syndrome (PCOS), is a common condition experienced by 10 percent of females, beginning in adolescence. It is a genetic condition that may result in an imbalance of ovarian hormones and insulin resistance.

Our PMOS care team has expertise in treating all symptoms and related conditions using the latest therapies. We offer comprehensive care with a personalized treatment plan that addresses your unique symptoms and needs.

We know PMOS can be challenging for people experiencing it, especially if you’re trying to get pregnant. Our team offers compassionate fertility and reproductive support and education as we guide you through your journey.

Complete care at the Penn PMOS Center of Excellence

As a designated Center of Excellence for Polyendocrine Metabolic Ovarian Syndrome (PMOS), the Penn PMOS Center in downtown Philadelphia provides specialized, whole-person care for complex cases.

Our center brings together top specialists in reproductive endocrinology, primary care, metabolic medicine, and behavioral health into a single, seamless care approach. Working as one team, we use advanced diagnostic tools and personalized care plans to pinpoint the cause of your symptoms and deliver clear answers, supporting your health from your teenage years through midlife.

At the center, our experts conduct advanced clinical research to study and develop highly effective treatments for PMOS. As a patient, you receive an accurate diagnosis, compassionate support, and direct access to clinical trials shaping the future of PMOS care.

PMOS care team and patient reviewing digital health data on a tablet at the hospital

Connect with a Penn PMOS Center specialist

Find an expert at the Penn PMOS Center for advanced diagnostics, research-backed care, and support.
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Clinical trials

Clinical trials offer patients the opportunity to try new and effective treatments and take part in future research.

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Second opinions

If you've received a diagnosis, our team of experts offers second opinions to grant you peace of mind.

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Our PMOS management

PMOS affects each person differently. The specialists at Penn Medicine understand the complexity of PMOS and the care required to manage it. Our team includes experts from a variety of fields, including:

PMOS treatment options

PMOS is a complex condition with a wide range of symptoms and related health issues. Because the experience of PMOS differs from one person to another, treatments will vary as well.

Depending on your symptoms and related conditions, we may recommend lifestyle modifications, such as diet and exercise. We may also prescribe medications to manage diabetes or regulate your hormones. For fertility issues caused by PMOS, we may recommend one or more of the following treatments:

IVF and assisted reproduction
Penn Fertility Care offers in vitro fertilization (IVF) and other assisted reproductive services.
Hysteroscopy
Hysteroscopy is a procedure to look at the inside of the womb (uterus). Your health care provider can look at the: Cervix, the opening to the wombInside of the wombOpenings of the fallopian tubes Cervix, the opening to the womb Inside of the womb Openings of the fallopian tubes This procedure is commonly used to diagnose bleeding problems in...
In vitro fertilization (IVF)
We help you overcome infertility and build your family with in vitro fertilization (IVF).
Ovulation induction
Ovulation induction can increase your pregnancy chances when paired with timed intercourse, IUI, or IVF.
Reproductive surgery
Our reproductive surgery specialists offer advanced, minimally invasive surgery for infertility.
Third-party reproduction
Our fertility care includes third-party reproduction services like egg, sperm, and embryo donation.
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Our doctors

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Locations

Our hospitals, multispecialty medical centers, pharmacies, labs and more offer outstanding, personalized care for patients all across the region.

Related articles

PMOS raises risk of heart disease

PMOS, formerly PCOS, is linked to higher rates of heart disease and blood clots that can cause heart attacks and strokes.

  • July 20, 2026

Women with PCOS on birth control do not raise certain risks

Birth control, taken alone or paired with metformin, did not raise metabolic syndrome risk, a precursor of heart disease and diabetes, in women with PCOS.

  • December 22, 2025

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