What is total skin electron beam therapy?
Total skin electron beam therapy (TSEBT) is a specialized radiation therapy that treats the entire skin surface of the body versus smaller localized areas. It’s typically used to treat the most common type of cutaneous (skin-based) T-cell lymphoma, also known as mycosis fungoides. This condition produces cancer cells in the skin that can display as red patches or other skin abnormalities.
TSEBT uses low-energy electron beams to treat superficial areas of the body. These electron beams do not penetrate deeply underneath the skin, so deeper tissues and organs are spared from damage. It targets the DNA of a tumor’s cells to eliminate them or slow their growth, while keeping normal cells healthy.
Radiation oncologists at Penn Medicine are recognized as leaders in radiation therapy with an established history of providing the most appropriate treatment options for each of our patients. Our doctors will assess your unique case and health history and determine whether total skin electron beam therapy is right for you based on your diagnosis.
Who is a candidate for electron beam cancer treatment?
Electron beam cancer treatment is a long-established radiation therapy used when large or widespread areas of the skin are impacted by lymphoma. Your symptoms may include:
- A patch that is flat, but has pigment changes or is scaly
- A thick, raised area
- Red skin that may be itchy
- A tumor or ulcerated nodule
Electron beam radiation therapy is often used if you have cutaneous T-cell lymphoma that has not been responsive to other treatments, such as ultraviolet light, photopheresis, topical agents, or medication. It may also be used in conjunction with other therapies.
Your doctor will review your symptoms and health history and decide whether electron radiation is the best option for your cancer treatment.
What to expect during electron beam therapy treatment
It’s easiest to deliver radiation to the entire surface of your body when you are in a standing position next to a linear accelerator (radiation) machine. There are two different delivery methods for treatment. In one method, your radiation therapist will ask you to change your position as they direct the radiation beams toward different parts of your body. In another method, you’ll stand on a rotating platform that exposes different parts of your body to
Your doctor will determine the frequency and overall duration of treatments. Often, you’ll receive multiple treatments per week for up to 10 weeks. You’ll be monitored throughout treatment to determine whether certain parts of your body need adjustments to the radiation dosage. For example, your hands and feet can be particularly sensitive to radiation and may need to be shielded from too much radiation, while other parts of your body may need extra radiation treatment. You may also wear goggles to protect your eyes from radiation. Each treatment session may be slightly different depending on the treatment plan and your reaction to previous treatments.
Recovery from total skin electron therapy
Many people have minimal side effects from electron beam radiation therapy though some experience effects after treatment. Short-term side effects may include fatigue, loss of appetite, nail loss, or burning or itchy skin. These symptoms typically resolve soon after treatment. Talk with your doctor about methods for addressing these symptoms so you can feel more comfortable.
In some cases, long-term side effects may develop such as hair loss, skin that feels dry or changes color, and changes in how your body sweats. Total skin electron beam therapy may also increase your skin cancer risk. It’s important that you talk with your doctor about any long-term symptoms and get support to lessen them with medications or other forms of therapy. Also, attend follow-up appointments with your doctor who may recommend additional screenings that can help you stay healthy.
Experts in electron beam radiation therapy
TSEBT is one of many highly effective radiation treatments offered at Penn Medicine. Our treatments are informed by research and use the latest technologies and techniques for the best possible outcomes. Our range of radiation treatments include those used specifically for certain types of cancer like cutaneous T-cell lymphoma.
Our expert radiology oncology doctors are supported by a team of radiation therapists, nurses, and clinical providers who specialize in delivering radiation treatments every day. When you come to Penn Medicine, you can be confident that you’ll be receiving the best care for you—before, during, and after treatment.
Rated “exceptional” by The National Cancer Institute
Penn Medicine’s Abramson Cancer Center is a world leader in cancer research, patient care, and education. Our status as a national leader in cancer care is reflected in our continuous designation as a Comprehensive Cancer Center by the National Cancer Institute (NCI) since 1973, one of 7 such centers in the United States. The ACC is also a member of the National Comprehensive Cancer Network, one of a select few cancer centers in the U.S., that are working to promote equitable access to high-quality, advanced cancer care.
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