Bleeding disorders

Living with a bleeding disorder can mean managing unexpected bleeding episodes and symptoms like bruising and pain. Our hematologists understand these challenges and provide advanced therapies that help your blood clot and improve your quality of life.
 Scientist analyzing blood samples at the laboratory and looking at the camera smiling

Setting higher standards in bleeding disorders care

Our compassionate team at the Comprehensive Hemophilia and Thrombosis Program is dedicated to protecting your health and easing your worries, enabling you to focus on what truly matters. We specialize in treating various bleeding disorders, including hemophilia, von Willebrand disease (VWD), and platelet disorders. Our team ensures you receive the best possible care tailored to your unique needs, whether your condition is inherited or acquired, or if your symptoms are mild or more severe.

What sets Penn Medicine apart is our team of renowned hematologists and specialized nursing staff, all deeply versed in the complexities of bleeding disorders. We’re also a CDC-designated center for hemophilia care, so we use the latest evidence-based treatments to improve your symptoms. Our doctors provide standard therapies, along with innovative treatments, like cell and gene therapies that have been approved to treat hemophilia.

Second opinions

If you've received a diagnosis, our team of experts offers second opinions to grant you peace of mind.

Schedule a second opinion
A young teen, of African decent, sits up on an exam table during a routine medical check-up. He is dressed casually and smiling as he talks with his doctor.

Leading-edge gene therapy for blood disorders 

Penn Medicine provides specialized gene therapy for certain blood disorders. These potentially life-changing treatments can provide transformational benefits, often with a single treatment. 

Conditions we treat

  • Heavy menstrual bleeding
  • Hemophilia
  • Thrombocytopenia
  • Von Willebrand disease

Wide-ranging, expert care for bleeding disorders

You have unique needs, depending on what type of bleeding disorder you have and your symptoms. Our providers create a treatment plan focused on you that helps you manage your condition over the long-term.

  • Complete, whole-person care: At Penn Medicine, you’ll have access to the full spectrum of care for bleeding disorders, often from a variety of specialists. Visits for inherited bleeding disorders, for example, may include a hematologist, nurse, physical therapist, social worker, and research coordinator. We also may refer you to orthopedic care specialists, if needed, or social workers to support your mental health and provide other services.
  • Physical therapy for bleeding disorder complications: Physical therapists at Penn Medicine are specially trained to help you manage bleeding in your muscles and joints. Our physical therapy services can help improve your mobility and function, support your recovery, and prevent complications, like falls.
  • Support for teens and young adults: We facilitate a smooth transition for younger patients moving to adult care, often collaborating with Children’s Hospital of Philadelphia.
  • Flexibility in personalized plans: Whether you need ongoing care or a second opinion, we're here to help. We can evaluate your treatment plan and offer options tailored to your needs.
  • Research-backed innovation: We actively contribute to developing new therapies, including gene therapy, to enhance treatment outcomes for hemophilia and other blood disorders.

Dedicated hematology services for heavy periods and recurrent miscarriages

Heavy periods and recurrent miscarriages may be linked to blood disorders. We have thrombosis and hemostasis specialists who work closely with people assigned female at birth. They offer evaluations and can coordinate family planning support for inherited bleeding and clotting conditions.

Diverse team of doctors having a discussion

Our doctors

Our providers work with you to plan and deliver exceptional treatment and personalized care.

Panoramic shot of Penn Medicine's downtown campus

Locations

Our hospitals, multispecialty medical centers, pharmacies, labs and more offer outstanding, personalized care for patients all across the region.

Related articles

Improving treatment for an autoimmune bleeding condition

More than half of patients who received an experimental treatment for immune thrombocytopenia maintained safe platelet counts without bleeding episodes for at least one year.

  • December 9, 2025

Gene therapy is potentially life-changing for hemophilia B

Adults with hemophilia B saw their number of bleeding episodes drop by an average of 71 percent after a single infusion of gene therapy.

  • September 25, 2024

Patient stories

After gene therapy, a lifetime of worries eased

After gene therapy, a lifetime of worries eased

Curt Krouse spent a lifetime worrying about injury because his hemophilia meant his blood might not clot. Then he received a new gene therapy at Penn. “It is hard to explain the feeling. I bang my arm or scratch my leg and instead of infusing, I just watch the affected area clot normally,” Krouse said. “It’s like a science fiction movie, but it’s real.”

Schedule an appointment

We can help you schedule an appointment or you can search our directory of specialists.