Biliary and pancreatic disease care

When your digestive system stops working the way it should, it can take highly specialized care to get you back on track. Penn Medicine uses the latest technology to diagnose and treat all disorders of the pancreas, gallbladder, and bile ducts.
Digital composite of highlighted red pancreas of woman

High-quality, patient-focused pancreatic care

Nearly 25 million Americans are affected by biliary and pancreatic disorders, from gallstones and bile duct issues to pancreatic cysts and cancer. At Penn Medicine, our specialists focus on these conditions every day, using advanced imaging, minimally invasive procedures, and complex surgeries—like the Whipple procedure and total pancreatectomy—to achieve the best outcomes.

As a Pancreatic Disease Center of Excellence and a high-volume surgical center, we handle some of the most challenging cases in the country. You can expect collaborative care from experts across multiple disciplines, with guidance every step of the way.

Clinical trials

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Second opinions

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Conditions we treat

  • Bile duct cancer
  • Bile duct obstruction
  • Bile duct stricture
  • Biliary atresia
  • Cholecystitis (gallbladder inflammation)
  • Gallbladder cancer
  • Gallbladder cancer diagnosis
  • Gallbladder cancer treatment
  • Gallstones
  • Jaundice
  • Pancreatic cancer
  • Pancreatic cyst
  • Pancreatitis
  • Primary biliary cholangitis
  • Primary sclerosing cholangitis

Pancreatic Disease Center of Excellence

Penn Medicine is recognized as a Center of Academic and Clinical Excellence for Pancreatitis by the National Pancreas Foundation (NPF). This designation is given to programs that meet strict standards for patient care and research. Our team of specialists includes gastroenterologists, pancreatic surgeons, and interventional radiologists, along with experts in pain management, nutrition, psychosocial support, and more. Together, we treat acute and chronic pancreatitis, including rare forms like hereditary and autoimmune pancreatitis.

Pancreatic Disease Center of Excellence

Pioneering techniques for accurate diagnosis and care

We offer advanced testing and treatment for all biliary and pancreatic diseases, from benign conditions to complex cancers involving the pancreas, bile ducts, gallbladder, and duodenum.

Cholecystectomy (gallbladder removal)
Cholecystectomy is gallbladder removal surgery to treat gallstones or other gallbladder dysfunctions.
Pancreatectomy (pancreas removal)
Pancreatectomy involves the partial or complete removal of the pancreas due to tumors or pancreatitis.
Radiation therapy
External radiation and internal radiation therapies are used to treat cancer and benign tumors.
Whipple procedure
A Whipple procedure can help treat cancerous and noncancerous pancreatic conditions.
3D Illustration of Human Body Organs Anatomy (Pancreas)

Unmatched experience in hepatobiliary and pancreas surgery

When surgery is needed, our hepatobiliary surgeons have the experience you need to treat your liver, pancreatic, gallbladder, or bile duct condition with precision. We see the highest patient volumes in the region and are often a destination for hard-to-treat cases.

Pancreatic Cyst Program

Penn Medicine’s Pancreatic Cyst Program is one of the few in the country dedicated to evaluating, treating, and monitoring pancreatic cysts. Each year, we care for more than 1,000 people, helping determine when a cyst can be safely watched and when treatment may be needed. Whether you’re newly diagnosed, unsure about the cause of a cyst, or seeking a second opinion, our program provides clear guidance. Our team also participates in ongoing research, so you’ll have access to the most promising advances in care.

Diverse team of doctors having a discussion

Our doctors

Our providers work with you to plan and deliver exceptional treatment and personalized care.

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Locations

Our hospitals, multispecialty medical centers, pharmacies, labs and more offer outstanding, personalized care for patients all across the region.

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