The McKay Orthopaedic Research Laboratory embodies the principles that guide orthopaedic research at the University of Pennsylvania: interdisciplinary effort, common-use facilities, scientific collaboration, and collegial discussion. The McKay Lab occupies more than 15,000 square feet of space in the School of Medicine, and is populated by more than 100 research personnel and six principal investigators.

Research expenditures in McKay total more than $5 million per annum, supported largely through extramural funding including grants from the National Institutes of Health (NIH), private foundations, and industry. Penn Orthopaedics is ranked in the top five of Orthopaedic Departments nationally in terms of NIH funding. Moreover, the McKay Lab serves as the focal point for the Penn Center for Musculoskeletal Disorders, a university-wide Center that provides resources and a forum for scientific exchange through annual symposia, a year-long seminar series, a pilot grant program and other activities.

Penn Orthopaedics research foci include:

  • Allotransplantation
  • Bone metabolism and cancer-associated bone diseases
  • Connective tissue extracellular matrix biophysics and cell biology
  • Fibrodysplasia Ossificans Progressiva and other disorders of heterotopic ossification
  • Genetic and cellular regulation of osteogenesis and chondrogenesis
  • Intervertebral disc and soft tissue mechanics
  • Mesenchymal stem cell maintenance and differentiation
  • Musculoskeletal aging and disease
  • Musculoskeletal tissue engineering
  • Stem cell mechanobiology
  • Tendon and ligament injury and repair

For more information, please visit the Department of Orthopaedic Medicine and Surgery.