Publications
Nelson F. Freeburg, Daniel Chafamo1, Gayathri Konanur Gopikrishna, Regan M. Murphy, Jacqueline J. Peng, Shridhar Parthasarathy, Sydney Dumont, Edward G. Estrada, Meghan T. Logun, Yusha Sun, Xin Wang, Payal Grover, Jesse L. Rodriguez, Daniel L. Zhang, Kristen Park, Yao Fu, Nadine Ben Hamouda, Isaias Hernandez-Verdin, Lamia Lamrani, Kelly A. Hicks, Natalie A. Cooper, Christina Ekwegbara, Emma Grace Bawden, Joshua J. Waterfall, Jaime Fuentealba, Marion Alcantara, John T. Seykora, Stephen M. Prouty, David Barrett, Esha Banerjee, Arin Cox, Charles-Antoine Assenmacher, Camilla Macia, Melinda Yin, Erica L. Carpenter, Guo-li Ming, Catherine Sautès-Fridman, Wolf H. Fridman, Eric Tartour, E. John Wherry, Sebastian Amigorena, Joseph A. Fraietta, MacLean P. Nasrallah, Hongjun Song, Tyler E. Miller, Stephen J. Bagley, Donald M. O’Rourke, Zev A. Binder*, Cécile Alanio*, Dana Silverbush* The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM , Cell: 2026
Sabra K Salim, Muhammad Vaseem Shaikh, Jeffrey Wei, William T Maich, Alisha Anand, Oliver Y Tang, Minomi K Subapanditha, Zahra Alizada, Yujin Suk, Manoj Singh, Kui Zhai, Aapti Khanna, Benjamin Brakel, Vassil Dimitrov, Zoya Tabunshchyk, Katie Chan, Kevin R Brown, Parvez Vora, Donald M O'Rourke, Zev A Binder, Chitra Venugopal, Jason Moffat, Sheila K Singh Generation of Allogeneic CAR-T Circumvents Functional Deficits in Patient-Derived Autologous Product for Glioblastoma , International Journal of Cancer: 2026
Elizabeth J Li, Adam Kraya, Pedro Costa-Pinheiro, Joshua Scheuermann, Anthony J Young, Erin Schubert, Mariam Aboian, Robert Doot, Jeffrey B Ware, Austin R Pantel, Zev A Binder, Phillip B Storm, Adam C Resnick, Nduka M Amankulor, Donald M O'Rourke, Arati Desai, MacLean P Nasrallah, Steven Brem, Stephen J Bagley, David Mankoff, Ali Nabavizadeh Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma , Journal of Nuclear Medicine: 2026
Zev A. Binder, Stephen J. Bagley, Jessica B. Foster & Donald M. O’Rourke The development of CAR T cells for patients with CNS malignancies , Nature Reviews Clinical Oncology: 2025
Kyosuke Shishikura, Jiasong Li, Yiming Chen, Nate R. McKnight, Thomas P. Keeley, Katelyn A. Bustin, Eric W. Barr, Snehil R. Chilkamari, Mahaa Ayub, Sun Woo Kim, Zongtao Lin, Ren- Ming Hu, Kelly Hicks, Xie Wang, Donald M. O’Rourke, J. Martin Bollinger Jr., Zev A. Binder, William H. Parsons, Kirill A. Martemyanov, Aimin Liu, Megan L. Matthews Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma , Science Advances, 11(42): 2025
Erica L Carpenter, Jacob E Till, Dominique Ballinger, Camilla Macia, Carlos Leche, Melinda Yin, Arati S Desai, Timothy Prior, Maikel Mansour, Emily McCoy, Thara Patel, Shivani Shah, H Isaac Chen, Eric Zager, Christina Jackson, Steven Brem, Zev A Binder, Donald M O'Rourke, Nduka Amankulor, Nike Beaubier, Stephen J Bagley Next-Generation Sequencing of Intraoperatively Acquired Cerebrospinal Fluid and Matched Tumor Tissue in Patients Undergoing Surgical Resection for Glioblastoma , JCO Precision Oncology: 2025
Benjamin Lin, Abigail K. Shelton, Erin Smithberger, Julia Ziebro, Kasey R. Skinner, Ryan E. Bash, Richard Kirkman, Allie Stamper, Madison Butler, Alex Flores, Steven P. Angus, Michael P. East, Timothy F. Cloughesy, David A. Nathanson, Michael E. Berens, Jann N. Sarkaria, Zev A. Binder, Donald M. O’Rourke, Timothy C. Howton, Brittany N. Lasseigne, Christopher D. Willey, Gary L. Johnson, Anita B. Hjelmeland, Frank B. Furnari & C. Ryan Miller Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma , Acta Neuropathologica Communications: 2025
Stephen J. Bagley, Arati S. Desai, Joseph A. Fraietta, Dana Silverbush, Daniel Chafamo, Nelson F. Freeburg, Gayathri Konanur Gopikrishna, Andrew J. Rech, Ali Nabavizadeh, Linda J. Bagley, Jungmin Park, Danuta Jarocha, Rene Martins, Nicolas Sarmiento, Eileen Maloney, Lester Lledo, Carly Stein, Amy Marshall, Rachel M. Leskowitz, Julie K. Jadlowsky, Shane Mackey, Shannon Christensen, Bike Su Oner, Gabriela Plesa, Andrea Brennan, Vanessa Gonzalez, Fang Chen, David Barrett, Robert Colbourn, MacLean P. Nasrallah, Zissimos Mourelatos, Wei-Ting Hwang, Cecile Alanio, Donald L. Siegel, Carl H. June, Elizabeth O. Hexner, Zev A. Binder & Donald M. O’Rourke Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial , Nature Medicine: 2025
Fathi Kazerooni A, Akbari H, Hu X, Bommineni V, Grigoriadis D, Toorens E, Sako C, Mamourian E, Ballinger D, Sussman R, Singh A, Verginadis II, Dahmane N, Koumenis C, Binder ZA, Bagley SJ, Mohan S, Hatzigeorgiou A, O'Rourke DM, Ganguly T, De S, Bakas S, Nasrallah MP, Davatzikos C. The radiogenomic and spatiogenomic landscapes of glioblastoma and their relationship to oncogenic drivers , Communications Medicine, 5(1): 2025
Sabrina L. Begley, Donald M. O’Rourke, and Zev A. Binder CAR T cell therapy for glioblastoma: A review of the first decade of clinical trials , Molecular Therapy: 2025
