Warren S. Pear, MD

Pathology and Laboratory Medicine
Sees patients age 18 and up
Penn Pathology and Laboratory Medicine HUP
Call 800-789-7366
Headshot of Warren S. Pear, MD
Penn Medicine Provider

About me

  • Gaylord P. and Mary Louise Harnwell Professor

My education and training

  • Medical School: University of Rochester School of Medicine
  • Residency: Mass General Brigham Healthcare Center - Chestnut Hill
  • Fellowship: Rockefeller University
  • Fellowship: Massachusetts Institute of Technology

Spoken languages

English
English

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Pear is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

McClory SE, Bardhan O, Rome KS, Giles JR, Baxter AE, Xu L, Gimotty PA, Faryabi RB, Wherry EJ, Pear WS, Jordan MS. The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR(+) CD8(+) effector state, and its deletion improves checkpoint blockade , Cell Rep, 42: 2023,112905

Li T, Bou-Dargham MJ, Fultang N, Li X, Pear WS, Sun H, Chen YH. c-Rel-dependent monocytes are potent immune suppressor cells in cancer , J Leukoc Biol: 2022

Gómez Atria D, Gaudette BT, Londregan J, Kelly S, Perkey E, Allman A, Srivastava B, Koch U, Radtke F, Ludewig B, Siebel CW, Ryan RJ, Robertson TF, Burkhardt JK, Pear WS, Allman D, Maillard I. Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naïve B cells , J Clin Invest: 2022

Zhou Y, Petrovic J, Zhao J, Zhang W, Bigdeli A, Zhang Z, Berger SL, Pear WS, Faryabi RB. EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells , Mol Cell, 82(5): 2022,1003-1020

Schwartz GW, Zhou Y, Petrovic J, Pear WS, Faryabi RB. TooManyPeaks identifies drug-resistant-specific regulatory elements from single-cell leukemic epigenomes , Cell Rep, 36: 2021,109575

Zheng Q, Capell BC, Parekh V, O'Day C, Atillasoy C, Bashir HM, Yeh C, Shim EH, Prouty SM, Dentchev T, Lee V, Wushanley L, Kweon Y, Suzuki-Horiuchi Y, Pear W, Grice EA, Seykora JT. Whole-Exome and Transcriptome Analysis of UV-Exposed Epidermis and Carcinoma In Situ Reveals Early Drivers of Carcinogenesis , J Invest Dermatol, 141: 2021,295-307

Kobia FM, Preusse K, Dai Q, Weaver N, Hass MR, Chaturvedi P, Stein SJ, Pear WS, Yuan Z, Kovall RA, Kuang Y, Eafergen N, Sprinzak D, Gebelein B, Brunskill EW, Kopan R. Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation , PLoS Biol, 18: 2020,e3000850

Zhang W, Pear WS. MYC degradation via AURKB inhibition: a new brake in the path to T-ALL , Blood Sci, 2: 2020,68-69

Rome KS, Stein SJ, Kurachi M, Petrovic J, Schwartz GW, Mack EA, Uljon S, Wu WW, DeHart AG, McClory SE, Xu L, Gimotty PA, Blacklow SC, Faryabi RB, Wherry EJ, Jordan MS, Pear WS. Trib1 regulates T cell differentiation during chronic infection by restraining the effector program , J Exp Med, 217: 2020,e20190888

Schwartz Gregory W, Zhou Yeqiao, Petrovic Jelena, Fasolino Maria, Xu Lanwei, Shaffer Sydney M, Pear Warren S, Vahedi Golnaz, Faryabi Robert B TooManyCells identifies and visualizes relationships of single-cell clades. , Nature Methods, 17(4): 2020,405-413

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