Tobias Raabe1 Dylan Haseman1 Andy Liu1 Khushal Bantu1 Vladimir Muzykantov1 Drew Weissman1 Jilian Melamed1 Jia Nong1, 1University of Pennsylvania A MASH PATIENT LIVER DERIVED 3D FIBROSIS MODEL FOR THE DESIGN AND VALIDATION OF CANDIDATE THERAPEUTIC LIPID NANOPARTICLES , AASLD supplement The Liver Meeting 2025: 2025

Liu, Andy' Haseman, Dylan; Bantu, Khushal; Muzykantov, Vladimir; Weissman, Drew; Melamed, Jilian; Nong, Jia; Raabe, Tobias Engineering a Fibrotic Scar Organoid Model for MASH Liver Disease , Scholarly Commons, University of Pennsylvania, CURF poster: 2025

Andy Liu, Dylan Haseman, Khushal Bantu, Jia Nong, Vladimir Muzykantov, Jilian Melamed, Michael Kegel, Jenna Muscat-Rivera, Drew Weissman, David Smith, Mei Zhang, Daniel J Rader, Tobias D Raabe Modeling Fibrosis with MASH Patient Liver-Derived Organoids. , biorxiv.org: 2025,2025.09. 18.677209

Dorottya Laczko 1, Patricia Y Tsao 2, Ruth-Anne Pai 3, Joseph Zinski 4, Michael V Gonzalez 2, Melanie Mumau 5, Tobias D Raabe 2, Hiromi Muramatsu 5, Norbert Pardi 2, Taku Kambayashi 6, David C Fajgenbaum 6 A patient-derived CABIN1 mutation recapitulates features of idiopathic multicentric Castleman disease in a mouse model , Blood Advances: 2025

Anagh A Sahasrabuddhe, Xiaofei Chen, Kaiyu Ma, Rui Wu, Huan-Chang Liang, Richa Kapoor, Rishi R Chhipa, Ozlem Onder, Courtney McFetridge, John S Van Arnam, Xiao Zhang, Jennifer JD Morrissette, Vinodh Pillai, Marilyn M Li, Philippe Szankasi, Venkatesha Basrur, Kevin P Conlon, Tobias D Raabe, Nathanael G Bailey, Cory M Hogaboam, Robert Rottapel, Junhyong Kim, Cristina López, Matthias Schlesner, Reiner Siebert, Kostiantyn Dreval, Ryan D Morin, Loredana Moro, Michele Pagano, Louis M Staudt, Megan S Lim, Kojo SJ Elenitoba-Johnson The FBXO45–GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis , Cancer Discovery , 15(4): 2025

Tobias D. Raabe, Jilian Melamed, Mohamad-Gabriel Alameh, Drew Weissman HUMAN ORGANOIDS FOR OPTIMIZATION OF LNP MEDIATED TARGETING OF NON PARENCHYMAL PATIENT LIVER CELL TYPES , ASGCT meeting Baltimore : 2024

Tobias D. Raabe, Sarah McCarron, Mohamad-Gabriel Alameh, Drew Weissman, Brooke Bathon LNPs for editing NASH patient liver derived organoids , American Society of Gene & Cell Therapy (ASGCT) Annual Meeting, Los Angeles, CA: 2023

Larsen LE, van den Boogert MAW, Rios-Ocampo WA, Jansen JC, Conlon D, Chong PLE, Levels JHM, Eilers RE, Sachdev VV, Zelcer N, Raabe T, He M, Hand NJ, Drenth JPH, Rader DJ, Stroes ESG, Lefeber DJ, Jonker JW, Holleboom AG Defective Lipid Droplet-Lysosome Interaction Causes Fatty Liver Disease as Evidenced by Human Mutations in TMEM199 and CCDC115 , Cell Mol Gastroenterol Hepatol, 13(2): 2022,583-597

Tobias D. Raabe, Sarah McCarron, Brooke Bathon Organoids derived from the liver of patients with NASH exhibit highly variable patient specific senescence phenotypes. , American Association for the Study of Liver Diseases (AASLD) Annual Meeting, New Orleans, LA: 2022

Lian Cui, Jeff Guo, Suna L Cranfill, Mayank Gautam, Janardhan Bhattarai, William Olson, Katherine Beattie, Rosemary C Challis, Qinxue Wu, Xue Song, Tobias Raabe, Viviana Gradinaru, Minghong Ma, Qin Liu, Wenqin Luo Glutamate in primary afferents is required for itch transmission , Neuron , 110(5): 2022,809-823