Elena B Riel, Weiming Bu, Thomas T Joseph, Leila Khajoueinejad, Roderic G Eckenhoff, Paul M Riegelhaupt The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel , Proceedings of the National Academy of Sciences, 122(14): 2025,e2421654122
Joseph Cichon, Thomas T Joseph, Xinguo Lu, Andrzej Z Wasilczuk, Max B Kelz, Steven J Mennerick, Charles F Zorumski, Peter Nagele Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect , Nature Communications, 16(1): 2025,2999
Joseph TT, Bu W, Haji-Ghassemi O, Chen YS, Woll K, Allen PD, Brannigan G, van Petegem F, Eckenhoff R. Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1) , British Journal of Anaesthesia: 2024
Johanna Becker-Baldus, Alexei Yeliseev, Thomas T. Joseph, Snorri Th. Sigurdsson, Lioudmila Zoubak, Kirk Hines, Malliga R. Iyer, Arjen van den Berg, Sam Stepnowski, Jon Zmuda, Klaus Gawrisch, and Clemens Glaubitz Probing the Conformational Space of the Cannabinoid Receptor 2 and a Systematic Investigation of DNP-Enhanced MAS NMR Spectroscopy of Proteins in Detergent Micelles , ACS Omega, 8(36): 2023,32963-32976
Joseph TT Best practices for resilient automation of biomolecular simulations , Methods in Cell Biology, 169: 2022,199-219
John T Petroff, Noah M Dietzen, Ezry Santiago-McRae, Brett Deng, Maya S Washington, Lawrence J Chen, K Trent Moreland, Zengqin Deng, Michael Rau, James AJ Fitzpatrick, Peng Yuan, Thomas T Joseph, Jérôme Hénin, Grace Brannigan, Wayland WL Cheng Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation , Nature Communications, 13(1): 2022,7017
Joseph TT, Bu W, Lin W, Zoubak L, Yeliseev A, Liu R, Eckenhoff RG, Brannigan G Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors , ACS Chem Neurosci, 12(9): 2021,1487–1497
Yeliseev A, Iyer MR, Joseph TT, Coffey NJ, Cinar R, Zoubak L, Kunos G, Gawrisch K Cholesterol as a modulator of cannabinoid receptor CB2 signaling , Scientific Reports, 11(3706): 2021
Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia B, Nimigean CM, Eckenhoff RG, Riegelhaupt PM Mechanistic insights into volatile anesthetic modulation of K2P channels , eLife, 21(9): 2020,e59839
Wenric S, Jeff JM, Joseph T, Yee M-C, Belbin GM, Owusu Obeng A, Ellis SB, Bottinger EP, Gottesman O, Levin MA, Kenny EE Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry , Pharmacogenomics Journal, 21(2): 2020,174–189
