Thomas T. Joseph, MD, PhD
Anesthesiology
Call 800-789-7366
Penn Medicine Provider

About me

  • Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania

As an anesthesiologist and computational biophysicist, I study anesthetic-protein binding with a focus on the lipid-embedded environment using molecular dynamics simulations. I also run various informatics projects in the Department of Anesthesiology and Critical Care at Penn Medicine, focused on clinical workflow improvement.

Education and training

  • Medical School: Mount Sinai School of Medicine
  • Residency: Mount Sinai Medical Center

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Joseph is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Elena B Riel, Weiming Bu, Thomas T Joseph, Leila Khajoueinejad, Roderic G Eckenhoff, Paul M Riegelhaupt The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel , Proceedings of the National Academy of Sciences, 122(14): 2025,e2421654122

Joseph Cichon, Thomas T Joseph, Xinguo Lu, Andrzej Z Wasilczuk, Max B Kelz, Steven J Mennerick, Charles F Zorumski, Peter Nagele Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effec , Nature Communications, 16(1): 2025,2999

Joseph TT, Bu W, Haji-Ghassemi O, Chen YS, Woll K, Allen PD, Brannigan G, van Petegem F, Eckenhoff R. Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1) , British Journal of Anaesthesia: 2024

Johanna Becker-Baldus, Alexei Yeliseev, Thomas T. Joseph, Snorri Th. Sigurdsson, Lioudmila Zoubak, Kirk Hines, Malliga R. Iyer, Arjen van den Berg, Sam Stepnowski, Jon Zmuda, Klaus Gawrisch, and Clemens Glaubitz Probing the Conformational Space of the Cannabinoid Receptor 2 and a Systematic Investigation of DNP-Enhanced MAS NMR Spectroscopy of Proteins in Detergent Micelles , ACS Omega, 8(36): 2023,32963-32976

Joseph TT Best practices for resilient automation of biomolecular simulations , Methods in Cell Biology, 169: 2022,199-219

John T Petroff, Noah M Dietzen, Ezry Santiago-McRae, Brett Deng, Maya S Washington, Lawrence J Chen, K Trent Moreland, Zengqin Deng, Michael Rau, James AJ Fitzpatrick, Peng Yuan, Thomas T Joseph, Jérôme Hénin, Grace Brannigan, Wayland WL Cheng Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation , Nature Communications, 13(1): 2022,7017

Joseph TT, Bu W, Lin W, Zoubak L, Yeliseev A, Liu R, Eckenhoff RG, Brannigan G Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors , ACS Chem Neurosci, 12(9): 2021,1487–1497

Yeliseev A, Iyer MR, Joseph TT, Coffey NJ, Cinar R, Zoubak L, Kunos G, Gawrisch K Cholesterol as a modulator of cannabinoid receptor CB2 signaling , Scientific Reports, 11(3706): 2021

Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia B, Nimigean CM, Eckenhoff RG, Riegelhaupt PM Mechanistic insights into volatile anesthetic modulation of K2P channels , eLife, 21(9): 2020,e59839

Wenric S, Jeff JM, Joseph T, Yee M-C, Belbin GM, Owusu Obeng A, Ellis SB, Bottinger EP, Gottesman O, Levin MA, Kenny EE Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry , Pharmacogenomics Journal, 21(2): 2020,174–189

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