Thomas T. Joseph, MD, PhD
Anesthesiology
Penn Medicine Provider
About me
- Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania
As an anesthesiologist and computational biophysicist, I study anesthetic-protein binding with a focus on the lipid-embedded environment using molecular dynamics simulations. I also run various informatics projects in the Department of Anesthesiology and Critical Care at Penn Medicine, focused on clinical workflow improvement.
My education and training
- Medical School: Mount Sinai Medical Center
- Residency: Mount Sinai Medical Center
Spoken languages
English
English
Insurance accepted
Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.
- Aetna Advantra Cares D-SNP
- Aetna Advantra Credit Value
- Aetna Advantra Eagle HMO
- Aetna Advantra Eagle POS
- Aetna Advantra Premier Plus PPO
- Aetna Advantra Value
- Aetna Advantra Value Plus
- Aetna APCN Plus (Multi-Tier)
- Aetna Better Health Kids (CHIP) - DH Only
- Aetna Flexible Five
- Aetna Freedom Core
- Aetna Gold
- Aetna HMO
- Aetna Philly Prime
- Aetna POS
- Aetna PPO APCN
- Aetna Premier
- Aetna Premier Plus
- Aetna Savings Plus
- Aetna Signature Administrators
- Aetna Student Health Plan PPO
- Aetna Upfront Advantage
- First Health HMO
- First Health POS
- First Health PPO
- Meritain - Aramark (Other)
- Meritain - Aramark (Pennsylvania Premier Medical Plan)
- Americhealth Caritas of PA VIP - LGH Only
- Amerihealth Caritas (Transplant patients only)
- Amerihealth Caritas of PA - LGH Only
- Capital Blue Cross/Capital Advantage Insurance Company
- Centivo EPO
- Cigna Healthcare EPO
- Cigna Healthcare HMO
- Cigna Healthcare POS
- Cigna Healthcare PPO
- Claim Watcher (Homestead/ INDECs) Open Access
Locations
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
- Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Qualifications and experience
- Anesthesiology, 2017
- American Society of Anesthesiologists, National
- International Anesthesia Research Society, International
- National Institutes of Health, National
- National Institutes of Health, National
Treatments and conditions
Research
Publications
Elena B Riel, Weiming Bu, Thomas T Joseph, Leila Khajoueinejad, Roderic G Eckenhoff, Paul M Riegelhaupt The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel , Proceedings of the National Academy of Sciences, 122(14): 2025,e2421654122
Joseph Cichon, Thomas T Joseph, Xinguo Lu, Andrzej Z Wasilczuk, Max B Kelz, Steven J Mennerick, Charles F Zorumski, Peter Nagele Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect , Nature Communications, 16(1): 2025,2999
Joseph TT, Bu W, Haji-Ghassemi O, Chen YS, Woll K, Allen PD, Brannigan G, van Petegem F, Eckenhoff R. Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1) , British Journal of Anaesthesia: 2024
Johanna Becker-Baldus, Alexei Yeliseev, Thomas T. Joseph, Snorri Th. Sigurdsson, Lioudmila Zoubak, Kirk Hines, Malliga R. Iyer, Arjen van den Berg, Sam Stepnowski, Jon Zmuda, Klaus Gawrisch, and Clemens Glaubitz Probing the Conformational Space of the Cannabinoid Receptor 2 and a Systematic Investigation of DNP-Enhanced MAS NMR Spectroscopy of Proteins in Detergent Micelles , ACS Omega, 8(36): 2023,32963-32976
Joseph TT Best practices for resilient automation of biomolecular simulations , Methods in Cell Biology, 169: 2022,199-219
John T Petroff, Noah M Dietzen, Ezry Santiago-McRae, Brett Deng, Maya S Washington, Lawrence J Chen, K Trent Moreland, Zengqin Deng, Michael Rau, James AJ Fitzpatrick, Peng Yuan, Thomas T Joseph, Jérôme Hénin, Grace Brannigan, Wayland WL Cheng Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation , Nature Communications, 13(1): 2022,7017
Joseph TT, Bu W, Lin W, Zoubak L, Yeliseev A, Liu R, Eckenhoff RG, Brannigan G Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors , ACS Chem Neurosci, 12(9): 2021,1487–1497
Yeliseev A, Iyer MR, Joseph TT, Coffey NJ, Cinar R, Zoubak L, Kunos G, Gawrisch K Cholesterol as a modulator of cannabinoid receptor CB2 signaling , Scientific Reports, 11(3706): 2021
Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia B, Nimigean CM, Eckenhoff RG, Riegelhaupt PM Mechanistic insights into volatile anesthetic modulation of K2P channels , eLife, 21(9): 2020,e59839
Wenric S, Jeff JM, Joseph T, Yee M-C, Belbin GM, Owusu Obeng A, Ellis SB, Bottinger EP, Gottesman O, Levin MA, Kenny EE Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry , Pharmacogenomics Journal, 21(2): 2020,174–189