Penn Medicine Provider
Neurosurgery
Steven Brem, MD
Accepting new patients
Sees patients age 18 and up
About me
- Course Director, Annual Penn Brain Tumor CME
- Site Director, Perelman School of Medicine Surgery Rotation - Neurosurgery at HUP
- Director, Neurosurgery Medical Student Education
- Professor CE of Neurosurgery
Education and training
- Medical School: Harvard University
- Residency: Massachusetts General Hospital
- Fellowship: NewYork-Presbyterian/Weill Cornell Medical Center
- Fellowship: University of California, Los Angeles
What my patients think about me
30 reviews
Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.
October 2020
We appreciate the top notch professionals in this office. Every level of care was excellent
September 2020
Dr Brem was awesome.
March 2020
constantly interrupted from explaining my condition to answer cellphone
January 2020
again the staff are very friendly and helpful
My Locations
Penn Neuroscience Center - Neurosurgery
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
- Pennsylvania Hospital: On the medical staff, but does not have privileges to treat patients in the hospital.
- Penn Presbyterian Medical Center: On the medical staff, but does not have privileges to treat patients in the hospital.
Qualifications and experience
- Neurological Surgery, 1983
- Advisory Board, Institute of Surgical Excellence, National
- American Brain Tumor Association, National
- American Brain Tumor Association, National
- American Brain Tumor Association-Discovery Grant Panel, National
- Appointed to NIH Review Panel, ZRG1 OTC-T(12)B, Small Business: Cancer Diagnostics and Treatments, National
- Central Brain Tumor Registry of the United States (CBTRUS), National
- Co-Chair, AACR/SNO-Neuro Tumor Club, National
- NCI Review Panel, Cancer Center Support Grant, P30, MD Anderson Comprehensive Cancer Center, National
- NCI Review Panel, Cancer Center Support Grant, P30, UCSF, National
- NCI SPORE Review Panel II, ZCA1 RPRB-0, National
- NCI-UCSF Cancer Center-Core Grant-CCSG-, National
- NIH / NCI, Brain Tumor Program Project Grant, National
- NIH Review Panel, ZRG1 OTC-T(12)B, Small Business: Cancer Diagnostics and Treatments, National
- NIH/NCATS Bench Testing Therapeutic/Indication Pairing Strategies (HU2/UH3) Review Special Emphasis Panel, National
- NIH/NCATS-ZTR1 CI-6-New Therapeutic Uses (NU) X02 Special Emphasis Panel-Grant Review, National
- NIH/NCI Spore Review-ZCA1 RPRB-7(MI) Group, National
- NIH-NCI, Brain Tumor SPORE (P50), ZCA1 RPRB-7 (MI),, National
- Society of Neuro-Oncology, National
- Penn Brain and Spinal Cord Tumors Program
- Penn Brain Tumor Center
Treatments and Conditions
My research
Akbari H, Bakas S, Sako C, Fathi Kazerooni A, Villanueva-Meyer J, Garcia JA, Mamourian E, Liu F, Cao Q, Shinohara RT, Baid U, Getka A, Pati S, Singh A, Calabrese E, Chang S, Rudie J, Sotiras A, LaMontagne P, Marcus DS, Milchenko M, Nazeri A, Balana C, Capellades J, Puig J, Badve C, Barnholtz-Sloan JS, Sloan AE, Vadmal V, Waite K, Ak M, Colen RR, Park YW, Ahn SS, Chang JH, Choi YS, Lee SK, Alexander GS, Ali AS, Dicker AP, Flanders AE, Liem S, Lombardo J, Shi W, Shukla G, Griffith B, Poisson LM, Rogers LR, Kotrotsou A, Booth TC, Jain R, Lee M, Mahajan A, Chakravarti A, Palmer JD, DiCostanzo D, Fathallah-Shaykh H, Cepeda S, Santonocito OS, Di Stefano AL, Wiestler B, Melhem ER, Woodworth GF, Tiwari P, Valdes P, Matsumoto Y, Otani Y, Imoto R, Aboian M, Koizumi S, Kurozumi K, Kawakatsu T, Alexander K, Satgunaseelan L, Rulseh AM, Bagley SJ, Bilello M, Binder ZA, Brem S, Desai AS, Lustig RA, Maloney E, Prior T, Amankulor N, Nasrallah MP, O'Rourke DM, Mohan S, Davatzikos C; ReSPOND consortium. Machine learning-based prognostic subgrouping of glioblastoma: A multicenter study , Neuro Oncol, 27: 2025,1102-1115
Wen PY, Manzanera A, Duault C, Gonzalez-Kozlova E, Lopez L, Grossman SA, Ye X, Fisher J, Lee I, Walbert T, Snyder J, Brem S, Desai A, Bagley SJ, Kakani C, Strowd R, Tatter S, Laxton A, Lesser G, Amankulor N, Lieberman F, Drappatz J, Mantica M, Triggs D, Haymaker C, Wistuba II, Al-Atrash G, Mendoza Perez J, Futreal A, Little LD, Islam MDH, Duose D, Jiang P, Reuben A, Lawler SE, Pichavant M, Gentles A, Bendall S, Kong A, Camacho C, Del Valle D, Kim-Schulze S, Gnjatic S, Sharon E, Nowicki MO, Peruzzi P, Lane D, Aguilar-Cordova E, Aguilar LK, Nichols G, Dwyer J, Tak PP, Maecker H, Barone F, Chiocca EA. A multi-institutional phase 1 clinical trial exploring upfront multimodal standard of care and combined immunotherapies for newly diagnosed glioblastoma , Neuro Oncol: 2025
de Godoy LL, Rajan A, Banihashemi A, Patel T, Desai A, Bagley S, Brem S, Chawla S, Mohan S. Response Assessment in Long-Term Glioblastoma Survivors Using a Multiparametric MRI-Based Prediction Model , Brain Sci, 15: 2025,146
Hosseini SA, Servaes S, Hall B, Bhaduri S, Rajan A, Rosa-Neto P, Brem S, Loevner LA, Mohan S, Chawla S. Quantitative Physiologic MRI Combined with Feature Engineering for Developing Machine Learning-Based Prediction Models to Distinguish Glioblastomas from Single Brain Metastases , Diagnostics (Basel), 15: 2024,38
Yadav VK, Mohan S, Agarwal S, de Godoy LL, Rajan A, Nasrallah MP, Bagley SJ, Brem S, Loevner LA, Poptani H, Singh A, Chawla S. Distinction of pseudoprogression from true progression in glioblastomas using machine learning based on multiparametric magnetic resonance imaging and O(6)-methylguanine-methyltransferase promoter methylation status , Neurooncol Adv, 6: 2024,vdae159
Tapescu I, Madsen PJ, Lowenstein PR, Castro MG, Bagley SJ, Fan Y, Brem S. The transformative potential of mRNA vaccines for glioblastoma and human cancer: technological advances and translation to clinical trials , Front Oncol, 14: 2024,1454370
Gongala S, Garcia JA, Korakavi N, Patil N, Akbari H, Sloan A, Barnholtz-Sloan JS, Sun J, Griffith B, Poisson LM, Booth TC, Jain R, Mohan S, Nasralla MP, Bakas S, Tippareddy C, Puig J, Palmer JD, Shi W, Colen RR, Sotiras A, Ahn SS, Park YW, Davatzikos C, Badve C; ReSPOND Consortium. Sex-Specific Differences in Patients with IDH1-Wild-Type Grade 4 Glioma in the ReSPOND Consortium , AJNR Am J Neuroradiol, 45: 2024,1299-1307
Brem S. Vagus nerve stimulation: Novel concept for the treatment of glioblastoma and solid cancers by cytokine (interleukin-6) reduction, attenuating the SASP, enhancing tumor immunity , Brain Behav Immun Health, 42: 2024,100859
Richardson TE, Walker JM, Hambardzumyan D, Brem S, Hatanpaa KJ, Viapiano MS, Pai B, Umphlett M, Becher OJ, Snuderl M, McBrayer SK, Abdullah KG, Tsankova NM. Genetic and epigenetic instability as an underlying driver of progression and aggressive behavior in IDH-mutant astrocytoma , Acta Neuropathol, 148: 2024,5
Liu J, Cao S, Imbach KJ, Gritsenko MA, Lih TM, Kyle JE, Yaron-Barir TM, Binder ZA, Li Y, Strunilin I, Wang YT, Tsai CF, Ma W, Chen L, Clark NM, Shinkle A, Naser Al Deen N, Caravan W, Houston A, Simin FA, Wyczalkowski MA, Wang LB, Storrs E, Chen S, Illindala R, Li YD, Jayasinghe RG, Rykunov D, Cottingham SL, Chu RK, Weitz KK, Moore RJ, Sagendorf T, Petyuk VA, Nestor M, Bramer LM, Stratton KG, Schepmoes AA, Couvillion SP, Eder J, Kim YM, Gao Y, Fillmore TL, Zhao R, Monroe ME, Southard-Smith AN, Li YE, Jui-Hsien Lu R, Johnson JL, Wiznerowicz M, Hostetter G, Newton CJ, Ketchum KA, Thangudu RR, Barnholtz-Sloan JS, Wang P, Fenyö D, An E, Thiagarajan M, Robles AI, Mani DR, Smith RD, Porta-Pardo E, Cantley LC, Iavarone A, Chen F, Mesri M, Nasrallah MP, Zhang H, Resnick AC, Chheda MG, Rodland KD, Liu T, Ding L; Philadelphia Coalition for a Cure; Clinical Proteomic Tumor Analysis Consortium. Multi-scale signaling and tumor evolution in high-grade gliomas , Cancer Cell, 42: 2024,1217-1238