Simon Chen, MD
Pathology and Laboratory Medicine
Headshot of Simon Chen, MD
Penn Medicine Provider

About me

  • Assistant Professor of Clinical Pathology and Laboratory Medicine

Education and training

  • Medical School: Washington University School of Medicine
  • Residency: Stanford University Medical Center
  • Fellowship: Stanford University Medical Center

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Chen is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Bian F, August A, Chen S, Lally S, Shields C, Milman T Correlation of PRAME expression by immunohistochemistry with genomic profiling: a comprehensive clinicopathologic study of 51 conjunctival melanomas , United States and Canadian Academy of Pathology Annual Meeting (San Antonio, Texas; poster): 2026


Shi WY, Liu KJ, Esfahani MS, Mach KE, Phillips NA, Almanza D, Bajpai RK, Schroers-Martin JG, Trabanino L, Lee TJ, La V, Rodriguez G, Holton G, Chen SB, Mullane P, Wu DJ, Nesselbush MC, Sugio T, Cheng JC, Jabara I, Hamilton EG, Alig SK, Liu CL, Peterson DJ, Prado K, Shkolyar E, Thong A, Shah JB, Gill H, Kunder CA, Chan E, Khaki AR, Skinner EC, Alizadeh AA, Liao JC, Diehn M Field-effect-informed urine liquid biopsy for bladder cancer , Cell, 189(4): 2026,1024-38


Bushara O, Devaro D, Ahn SS, Dourlain J, Farooq MS, Brunetti A, Chen S, Feldser D, Kucharczuk JC, Singhal S Characterizing the clinical and molecular profile of SETD2-mutated lung adenocarcinoma , Cancers, 17(21): 2025,3540


Landi AS, Cappas-Navarro B, Kalghatgi T, Rimal A, Chitturi A, Gentile C, Herlihy SE, Chen S Race against the clock: validating a rapid NGS myeloid panel , Association for Molecular Pathology Annual Meeting (Boston, Massachusetts; poster): 2025


Wadsworth PA, Chen SB, Lawrence L, Ho CC, Le JE, Libiran P, Grayson PC, Ferrada MA, Beck DB, Suarez CJ Rapid clinical deployment of UBA1 testing in patients with VEXAS syndrome , American Journal of Clinical Pathology, 164(3): 2025,360-6


Kim JS, Priore SF, Chen SB, Morrissette JJ, Fortuna D, Haye KK, Harris JC, Poniatowski N, Yang G Rare cases of gastrointestinal stromal tumors with concomitant KIT and SDH gene mutations: a single-institution experience , Association for Molecular Pathology Annual Meeting (Vancouver, British Columbia, Canada; poster): 2024


Elghawy O, Barsouk A, Xu J, Chen S, Cohen RB, Sun L Real world outcomes of cabozantinib therapy in poorly differentiated thyroid carcinoma , European Thyroid Journal, 13(6): 2024,e240225


Madabhushi SC, Chaum M, Chen SB, Fogt F, Lal P Exploring molecular signatures in primary seminal vesicle adenocarcinoma: insights from next generation sequencing , College of American Pathologists Annual Meeting (Las Vegas, Nevada; poster): 2024


Elghawy O, Barsouk A, Heidlauf A, Chen S, Cohen RB, Sun L Single-institution experience of larotrectinib therapy for patients with NTRK fusion-positive thyroid carcinoma , Journal of the Endocrine Society, 8(10): 2024,bvae158


Yin CC, Tam W, Walker SM, Kaur A, Ouseph MM, Xie W, Weinberg OK, Li P, Zuo Z, Routbort MJ, Chen S, Medeiros LJ, George TI, Orazi A, Arber DA, Bagg A, Hasserjian RP, Wang SA STAT5B mutations in myeloid neoplasms differ by disease subtypes but characterize a subset of chronic myeloid neoplasms with eosinophilia and/or basophilia , Haematologica, 109(6): 2024,1825