Sharlene M. Day, MD

Cardiology
Accepting new patients
Sees patients age 16 and up
Penn Heart and Vascular Center
Penn Medicine Provider

About me

  • Director, Translational Research, Division of Cardiovascular Medicine and Cardiovascular Institute
  • Presidential Professor

My education and training

  • Medical School: New York University School of Medicine
  • Residency: University of Michigan Health
  • Fellowship: University of Michigan Health

Spoken languages

English
English

Reviews

Average Rating

312 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
June 2026
dr day shows concern for my health and follows up on previous issues from detailed notes
Anonymous
June 2026
dr. day spends time trying to make you whole again. she reviews and compares past and present records.
Anonymous
May 2026
great care and support
Anonymous
May 2026
dr day is always very thoughtful and kind. my echo ran very overtime and she was incredibly flexible with accommodating my later arrival due to testing

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. Day is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Walsh R, Mazzarotto F, Whiffin N, Buchan R, Midwinter W, Wilk A, Li N, Felkin L, Ingold N, Govind R, Ahm, ad M, Mazaika E, Allouba M, Zhang X, de Marvao A, Day SM, Ashley E, Colan SD, Michels M, Pereira AC, Jacoby D, Ho CY, Thomson KL, Watkins H, Barton PJR, Olivotto, I, Cook SA, Ware JS. Quantitative Approaches to Variant Classification Increase the Yield and Precision of Genetic Testing for Mendelian Diseases: The Case for Hypertrophic Cardiomyopathy. , Genome Medicine, 11(1): 2019,5


Garratt M, Leander D, Pifer K, Herrera J, Day SM, Fiehn O, Brooks S, Miller RA. 17-alpha Estradiol Ameliorates Age-Associated Sarcopenia and Improves Late Life Physical Function in Male Mice But Not in Females or Castrated Males , Aging Cell, 18(2): 2019,e12920


Day SM Nonobstructive Hypertrophic Cardiomyopathy: The High Hanging Fruit. , JAMA Cardiol, 4(3): 2019 ,235-236


Vigneault DM, Yang E, Jensen PJ, Tee MW, Farhad H, Chu L, Noble JA, Day SM, Colan SD, Russell MW, Towbin J, Sherrid MV, Canter CE, Shi L, Ho CY, Bluemke DA Left Ventricular Strain Is Abnormal in Preclinical and Overt Hypertrophic Cardiomyopathy: Cardiac MR Feature Tracking. , Radiology, 290(3): 2019,640-48


Smith ED, Tome J, Mcgrath R, Kumar S, Concannon M, Day SM, Saberi S, Helms AS Exercise hemodynamics in hypertrophic cardiomyopathy identify risk of incident heart failure but not ventricular arrhythmias or sudden cardiac death. , Int J Cardiol, 274: 2019,226-231


O'Leary TS, Snyder J, Sadayappan S, Day SM, Previs MJ MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy. , J Mol Cell Cardiol, 127: 2019,165-173


Glazier AA, Thompson A, Day SM Allelic imbalance and haploinsufficiency in MYBPC3-linked hypertrophic cardiomyopathy. , Pflugers Arch, 471(5): 2019,781-793


Ho CY, Day, SM, Ashley EA, Michels M, Pereira A, Jacoby D, Fox J, Caleshu C, Cirino AL, Ware J, Helms AS, Colan SD, Signorovich J, Green E, Olivotto I Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy: Insights from the Sarcomeric Human Cardiomyopathy Registry (SHaRe). , Circulation, 138(14): 2018,1387-98


Ahmad F, McNally EM, Ackerman MJ, Baty LC, Day SM, Kullo IJ, Madueme PC, Maron MS, Martinez MW, Salberg L, Taylor MR, Wilcox JE. Establishment of Specialized Clinical Cardiovascular Genetics Programs: Recognizing the Need and Meeting the Standards , Circ Genom Precis Med, 12(6): 2019,e000054


Ko C, Arscott P, Saberi S, Concannon M, Day SM, Yashar BM, Helms AS Genetic Testing Impacts the Utility of Prospective Familial Screening in Hypertrophic Cardiomyopathy Through Identification of a Non-Familial Subgroup , Genetics in Medicine, 20(1): 2018,69-75


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