Samantha Zuckerman, MD, MBE

Radiology
Accepting new patients
Sees patients age 18 and up
Call 800-789-7366
Headshot of Samantha Zuckerman, MD, MBE
Penn Medicine Provider

About me

  • Breast Imaging Fellowship Director
  • Co-Chair, Hospital of the University of Pennsylvania Ethics Committee
  • Associate Professor of Clinical Radiology

I am a board-certified, fellowship-trained breast radiologist. I work closely and collaboratively with a multidisciplinary team to provide the most appropriate breast imaging and minimially invasive breast procedures to our patients.

In a typical day, I interpret screening and diagnostic mammograms, perform and interpret breast ultrasound, and read breast MRIs. I also perform image guided minimally invasive procedures. While I enjoy the diagnostic and procedural components of my work, the most meaningful and my most favorite aspects of my job are my interactions with our patients. As a breast imager, my role is to not only detect breast abnormalities, but to explain the imaging findings and my recommendations to our patients. I am often the first person to tell a patient they have breast cancer - I take this role very seriously and am honored to help patients understand their disease and their next treatment steps.

My research is focused on emerging screening technologies (breast tomosynthesis, synthetic imaging, abbreviated MRI) and reducing disparities in access to screening. I am also dedicated to education - I am the breast imaging fellowship director and actively teach residents and medical students.

I am also the Co-Chair of Hospital of the University of Pennsylvania's ethics committee and a member of the hospital ethics consultative service. In this role, I help facilitate conversations with our patients and their medical team around complex medical decision making and treatment choices.

My education and training

  • Medical School: Mount Sinai Medical Center
  • Residency: Memorial Sloan-Kettering Cancer Center
  • Residency: University of Pennsylvania Health System
  • Fellowship: University of Pennsylvania Health System

Spoken languages

English
English

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Chester County Hospital: Has privileges to treat patients in the hospital.
Dr. Zuckerman is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

Research

Publications

Joseph J Villavicencio 1, Sophia R O'Brien 1, Tom Hu 2, Samantha Zuckerman 1 Cystic Neutrophilic Granulomatous Mastitis: Imaging Features With Histopathologic Correlation , J Breast Imaging, 7(2): 2025

Anthony J Young 1, Austin R Pantel 1, Mahsa Kiani 1, Robert K Doot 1, Sina Bagheri 1, Daniel A Pryma 1, Michael D Farwell 1, Shihong Li 1, Hsiaoju Lee 1, Erin K Schubert 1, Anthony Secreto 2, Samantha P Zuckerman 1, Anupma Nayak 3, Hoon Choi 1, Sean Carlin 4, Angela DeMichele 5, David A Mankoff 1, Rong Zhou 1, Robert H Mach 1, Elizabeth S McDonald 6 Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted 18F-Fluorthanatrace PET in Breast Cancer , J Nucl Med, 65(12): 2024

Villavicencio, J.J., Zuckerman, S.P. Case-Based Review of Breast Imaging Changes Associated With GLP-1 Agonists , Curr Radiol Rep, 13(2): 2025

Samantha P Zuckerman 1, Senthil Periaswamy 2, Julie L Shisler 1 3, Ameena Elahi 1, Christine E Edmonds 1, Jeffrey Hoffmeister 4, Emily F Conant 1 Evaluating the Impact of Changes in Artificial Intelligence-derived Case Scores over Time on Digital Breast Tomosynthesis Screening Outcomes , Radiol Artif Intell.: 2025

David N, Donuru A, Zuckerman SP, O’Brien SR, Nayak A, Araki T, Xu D, Nachiappan AC Hyperdense Pleural Metastasis from Osteosarcomatous Breast Phyllodes Tumor. , J Med Imaging Case Rep , 7(2): 2023,39-42

Damien Medrano, Samantha P Zuckerman UNKNOWN CASE: PEDIATRIC BREAST MASS , Journal of Breast Imaging: 2025

Christine E Edmonds, Susan P Weinstein, Elizabeth S McDonald, Sina Bagheri, Samantha P Zuckerman, Sophia R O'Brien, Mitchell D Schnall, Emily F Conant Abbreviated Breast MRI for Supplemental Screening in Patients With Dense Breasts: Comparison of Baseline Versus Subsequent-Round Examinations , AJR Am J Roentgenol: 2024

Sophia R O’Brien, MD, Samantha P Zuckerman, MD, MBE Palpable Fibroadenoma in a Transgender Woman , Journal of Breast Imaging, 4(4): 2022,443–444

Janine Katzen; Gary Whitman; Samantha Zuckerman; Jonathan Nguyen; Lilian Wang; Victoria Mango Breast Imaging Fellowship Virtual Interviews: The Program Director’s Perspective , Journal of Breast Imaging, 6(1): 2024,80-85

Samantha P Zuckerman and Elizabeth S McDonald Breast Imaging: The Core Requisites Chapter 20: Mammography Quality Standards Act (MQSA) and American College of Radiology (ACR) Accreditation Programs , Elseiver, 4th: 2022