Ronald P. DeMatteo, MD, FACS
Endocrine and Oncologic Surgery
Headshot of Ronald P. DeMatteo, MD, FACS

Ronald P. DeMatteo, MD, FACS

Endocrine and Oncologic Surgery
Accepting new patients
Sees patients age 18 and up
Penn Endocrine and Oncologic Surgery Perelman 4th Floor
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Headshot of Ronald P. DeMatteo, MD, FACS
Penn Medicine Provider

About me

  • Chair, Department of Surgery
  • John Rhea Barton Professor of Surgery

Dr. DeMatteo is the Chairman of the Department of Surgery and a Surgical Oncologist who specializes in treating diseases of the liver, bile duct, gallbladder, pancreas and abdominal sarcomas (GIST).

His clinical research has focused on liver, bile duct, gallbladder, and pancreas cancers. In addition, he has led several national trials testing the benefit of imatinib mesylate (Gleevec) following surgery for gastrointestinal stromal tumor (GIST), a tumor that usually begins in the stomach or intestine.

In the laboratory he and his colleagues study the immune environment of the liver and tumor immunology, working to develop immune therapies to help prevent tumors from returning after surgery.

My education and training

  • Cornell UniversityMedical School
  • University of Pennsylvania Health SystemResidency
  • Memorial Sloan-Kettering Cancer CenterResidency
Watch video featuring Ronald P. DeMatteo, MD, FACS on YouTube

Spoken languages

English
English

Reviews

Average Rating

387 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
September 2026
Simply the best
Anonymous
July 2026
outstanding! very pleased with dr. dematteo.
Anonymous
July 2026
the dr delivered some less good news about cancer spread without then explaining what that would mean for future treatment or asking if i had questions. i am trying to process but struggling.
Anonymous
July 2026
totally recommend him. he also is my husband's doctor as well. top doc !

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
Dr. DeMatteo is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Song Y, Tang R, Roses RE, Fraker DL, DeMatteo RP, Kelz RR, Karakousis GC. Opioid Use Disorder is Associated With Complications and Increased Length of Stay After Major Abdominal Surgery. , Ann Surg: 2019


Chen B, Trudeau MT, Maggino L, Ecker BL, Keele LJ, DeMatteo RP, Drebin JA, Fraker DL, Lee MK 4th, Roses RE, Vollmer CM Jr. Defining the safety profile for performing pancreatoduodenectomy in the setting of hyperbilirubinemia. , Ann Surg Oncol: 2019


Cercek A, Boerner T, Tan BR, Chou JF, Gonen M, Boucher TM, Hauser HF, Do RKG, Lowery MA, Harding JJ, Varghese AM, Reidy-Lagunes D, Saltz L, Schultz N, Kingham TP, D'Angelica MI, DeMatteo RP, Drebin JA, Allen PJ, Balachandran VP, Lim KH, Sanchez-Vega F, Vachharajani N, Majella Doyle MB, Fields RC, Hawkins WG, Strasberg SM, Chapman WC, Diaz LA Jr, Kemeny NE, Jarnagin WR. Assessment of hepatic arterial infusion of floxuridine in combination with systemic gemcitabine and oxaliplatin in patients with unresectable intrahepatic cholangiocarcinoma: A phase 2 clinical trial. , JAMA Oncol: 2019


Gamboa AC, Aveson VG, Zaidi MY, Lee RM, Jarnagin WR, Allen PJ, Drebin JA, Peter Kinghamm T, DeMatteo RP, Sarmiento JM, Russell MC, Cardona K, Kooby DA, D'Angelica MI, Maithel SK. Lending a hand for laparoscopic distal pancreatectomy: the optimal approach? , HPB: 2019


Ganesh K, Wu C, O'Rourke KP, Szeglin BC, Zheng Y, Sauve CG, Adileh M, Wasserman I, Macro MR, Kim AS, Shady M, Sanchez-Vega F, Karthaus WR, Won HH, Choi SH, Pelossof R, Barlas A, Ntiamoah P, Pappou E, Elghouayel A, Strong JS, Chen CT, Harris JW, Weisser MR, Nash GM, Guillem JG, Wei IH, Kolesnick RN, Veeraraghavan H, Ortiz EJ, Petkovska I, Cercek A, Manova-Todorova KO, Saltz LB, Lavery JA, DeMatteo RP, Massague J, Paty PB, Yaeger R, Chen X, Patil S, Clevers H, Berger MF, Lowe SW, Shia J, Romesser PB, Dow LE, Garcia-Aguilar J, Sawyers CL, Smith JJ. A rectal cancer organoid platform to study individual responses to chemoradiation. , Nat Med, 25: 2019,1607-14


Glauser G, Osiemo B, Goodrich S, McClintock SD, Vollmer C, DeMatteo RP, Malhotra NR. Association of Overlapping, nonconcurrent, surgery with patient outcomes at a large academic medical center: A coarsened exact matching study. , Ann Surg, 270: 2019,620-9


Basta MN, Kozak GM, Broach RB, Messa CA 4th, Rhemtulla I, DeMatteo RP, Serletti JM, Fischer JP. Can we predict incisional hernia?: Development of a surgery-specific decision-support interface. , Ann Surg, 270: 2019,544-53


Song Y, Ecker BL, Tang R, Maggino L, Roses RE, DeMatteo RP, Fraker DL, Karakousis GC. Trends in practice patterns and outcomes: A decade of sarcoma care in the United States. , Surg Oncol, 29: 2019,168-77


Butler PD, Aarons CB, Ahn J, Wein AJ, Ruckenstein MJ, Lett LA, DeMatteo RP, Serletti JM. Leading from the front: An approach to increasing racial and ethnic diversity in surgical training programs. , Ann Surg, 269: 2019,1012-5


Santamaria-Barria JA, Zeng S, Greer JB, Beckman MJ, Seifert AM, Cohen NA, Zhang JQ, Crawley MH, Green BL, Loo JK, Maltbaek JH, DeMatteo RP. CSflr or Mer inhibition delays liver regeneration via suppression of Kupffer cells. , PLoS One, 14: 2019