Ron C. Anafi, MD, PhD
Sleep Medicine
Accepting new patients
Sees patients age 18 and up
Penn Sleep Center Market Street
Schedule onlineCall 215-662-7772
Penn Medicine Provider

About me

  • Associate Professor of Medicine (Sleep Medicine) at the Hospital of the University of Pennsylvania

Education and training

  • Medical School: University of Minnesota Medical School
  • Residency: University of Vermont Medical Center
  • Fellowship: Hospital of the University of Pennsylvania

What my patients think about me

Average Rating

129 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

September 2025
dr anafi is very interested in my health.
August 2025
10 out of 10
August 2025
he seems to care and he listens and explains this well
August 2025
personable, thorough, insightful, super smart

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
Dr. Anafi is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Anafi RC, Francey LJ, Hogenesch JB, Kim J CYCLOPS reveals human transcriptional rhythms in health and disease , Proceedings of the National Academy of Sciences of the United States of America, 114(20): 2017,5312-5317

Hollis HC, Sharma A, Sheehan PW, Maggi LB, Weber JD, Hammarlund JA, Bennett DA, Menon V, *Musiek ES, *Anafi RC Reconstructed cell-type-specific rhythms in human brain link Alzheimer's pathology, circadian stress, and ribosomal disruption , Neuron, 113: 2025,1-17

Li SY, Hammarlund JA, Wu G, Lian JW, Howell SJ, Clarke RB, Adamson AD, Gonçalves CF, Hogenesch JB, *Anafi RC, *Meng QJ. Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer , Proc Natl Acad Sci U S A, 121: 2024,e2311854121

Anafi RC, Kayser MS, Raizen DM Exploring phylogeny to find the function of sleep , Nature Reviews. Neuroscience, 20(2): 2019,109-116

Anafi RC, Lee Y, Sato TK, Venkataraman A, Ramanathan C, Kavakli IH, Hughes ME, Baggs JE, Growe J, Liu AC, Kim J, Hogenesch J Machine learning helps identify CHRONO as a circadian clock component , PLoS Biology, 12(4): 2014,e1001840

Ruben MD, Wu G, Smith DF, Schmidt RE, Francey LJ, Lee YY, Anafi RC, Hogenesch JB A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine , Science Translational Medicine, 10(458): 2018,eaat8806

Zhang R, Podtelezhnikov AA, Hogenesch JB, Anafi RC Discovering biology in periodic data through Phase Set Enrichment Analysis (PSEA) , Journal of Biological Rhythms, 31(3): 2016,244-257

Krishnaiah SY, Wu G, Altman B, Growe J, Rhoades SD, Coldren F, Venkataraman A, Olarerin-George AO, Francey LJ, Mukherjee S, Girish S, Selby CP, Cal S, Er U, Sianati B, Sengupta A, Anafi RC, Kavakli IH, Sancar A, Baur JA, Dang CV, Hogenesch JB, Weljie AM Clock regulation of metabolites reveals coupling between transcription and metabolism , Cell Metabolism, 25(4): 2017,961-974.e4

Ben-Zvi D, Meoli L, Abidi WM, Nestoridi E, Panciotti C, Castillo E, Pizarro P, Shirley E, Gourash WF, Thompson CC, Munoz R, Clish CB, Anafi RC, Courcoulas AP, Stylopoulos N Time-Dependent Molecular Responses Differ between Gastric Bypass and Dieting but Are Conserved Across Species , Cell Metabolism, 28(2): 2018,310-323.e6

Cal-Kayitmazbatir S, Kulkoyluoglu-Cotul E, Growe J, Selby CP, Rhoades SD, Malik D, Oner H, Asimgil H, Francey LJ, Sancar A, Kruger WD, Hogenesch JB, Weljie A, *Anafi RC, *Kavakli IH CRY1-CBS binding regulates circadian clock function and metabolism , The FEBS Journal, 288(2): 2021,614-639