About me
- Mary Black Ralston Professor for Education and Research in Orthopaedic Surgery
- Professor of Orthopaedic Surgery in Physical Medicine and Rehabilitation
My Locations
Qualifications and experience
- American Society of Mechanical Engineers, National
- AO Foundation, Pilot Grant Program, International
- AO Spine, International
- Arthritis Foundation, National
- Biomedical Engineering Society, National
- Department of Veterans Affairs Rehabilitation Research and Development Service, National
- Department of Veterans Affairs, BLR&D and CSR&D Services, National
- Engineering Conferences International (ECI), International
- Food and Drug Administration (FDA), Orthopaedic and Rehabilitation Panel, Center for Devices adn Radiological Health (CDRH), National
- International Cartilage Repair Society (ICRS), International
- Materials Research Society, National
- National Institutes of Health, National
- National Science Foundation, National
- Orthopaedic Research Society, National
- Philadelphia VA Medical Center and VISN4, Local
- Pilot Grant Program, Penn Center for Musculoskeletal Disorders, Local
- Qatar National Research Fund (QNRF), International
- Science Foundation of Ireland, International
- Society for the Physical Regulation of Biology in Medicine (SPRBM), International
- Tissue Engineering and Regenerative Medicine International Society (TERMIS), International
- UPenn Institute on Aging, Local
Treatments and Conditions
My research
Xu KL, Di Caprio N, Fallahi H, Dehghany M, Davidson MD, Laforest L, Cheung BCH, Zhang Y, Wu M, Shenoy V, Han L, Mauck RL, Burdick JA. Microinterfaces in biopolymer-based bicontinuous hydrogels guide rapid 3D cell migration , Nat Commun, 15: 2024,2766
Lemmon EA, Burt KG, Kim SY, Kwok B, Laforest L, Xiao R, Han L, Scanzello CR, Mauck RL, Agnello KA. Interleukin receptor therapeutics attenuate inflammation in canine synovium following cruciate ligament injury , Osteoarthritis Cartilage: 2024
Bonnevie ED, Gullbrand SE, Ashinsky BG, Tsinman TK, Elliott DM, Chao PG, Smith HE, Mauck RL. Aberrant mechanosensing in injured intervertebral discs as a result of boundary-constraint disruption and residual-strain loss , Nat Biomed Eng: 2019
Heo SJ, Song KH, Thakur S, Miller LM, Cao X, Peredo AP, Seiber BN, Qu F, Driscoll TP, Shenoy VB, Lakadamyali M, Burdick JA, Mauck RL. Nuclear softening expedites interstitial cell migration in fibrous networks and dense connective tissues , Sci Adv, 6: 2020,eaax5083
Zlotnick HM, Clark AT, Gullbrand SE, Carey JL, Cheng XM, Mauck RL. Magneto-Driven Gradients of Diamagnetic Objects for Engineering Complex Tissues , Adv Mater: 2020
Patel JM, Loebel C, Saleh KS, Wise BC, Bonnevie ED, Miller LM, Carey JL, Burdick JA, Mauck RL. Stabilization of Damaged Articular Cartilage with Hydrogel-Mediated Reinforcement and Sealing , Adv Healthc Mater: 2021
Heo SJ, Thakur S, Chen X, Loebel C, Xia B, McBeath R, Burdick JA, Shenoy VB, Mauck RL, Lakadamyali M. Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues , Nat Biomed Eng: 2023
Jones DL, Hallström GF, Jiang X, Locke RC, Evans MK, Bonnevie ED, Srikumar A, Leahy TP, Nijsure MP, Boerckel JD, Mauck RL, Dyment NA. Mechanoepigenetic regulation of extracellular matrix homeostasis via Yap and Taz , Proc Natl Acad Sci U S A, 120: 2023,e2211947120
Bonnevie ED, Scanzello CR, Mauck RL. Modulating mechanobiology as a therapeutic target for synovial fibrosis to restore joint lubrication , Osteoarthritis Cartilage: 2023
Peredo AP, Gullbrand SE, Friday CS, Orozco BS, Dehghani B, Jenk AC, Bonnevie ED, Hilliard RL, Zlotnick HM, Dodge GR, Lee D, Engiles JB, Hast MW, Schaer TP, Smith HE, Mauck RL. Tension-activated nanofiber patches delivering an anti-inflammatory drug improve repair in a goat intervertebral disc herniation model , Sci Transl Med, 15: 2023,eadf1690