Robert H. Mach, PhD
Penn Medicine Provider

About me

  • Britton Chance Professor of Radiology

Insurance accepted

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My research

Stehouwer JS, Huang G, Saturnino Guarino D, Debnath ML, Polu A, Geib SJ, Lopresti B, Ikonomovic MD, Mason N, Mach RH, Mathis CA Structure-Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1 H-indoles as Tauopathy Positron Emission Tomography Radiotracers , Journal of Medicinal Chemistry, Vol 68/Issue 6: 2025 ,6462-6492


Dubroff JG, Hsieh CJ, Wiers CE, Lee H, Li EJ, Schubert EK, Mach RH, Kranzler HR [11C]Carfentanil PET Whole-Body Imaging of Mu-Opioid Receptors: A First In-Human Study , J. Nucl. Med, 66(1112-1118): 2025,1112-1118


Hsieh C-J, Saturnino Guarino D, Young AJ, Siderowf AD, Nasrallah I, Schmitz A, Garcia C, Kim HY, Schubert EK, Lee H, Perlmutter JS, Mach RH Pilot Study of [11C]HY-2-15: A Mixed Alpha-Synuclein and Tau PET Radiotracer , Cells, 14(1157): 2025


Zhao H, Huang T, Dhavale DD, O’Shea JY, Lengyel-Zhand Z, Saturnino Guarino D, Gu J, Yue X, Nai Y-H, Jiang H, Lougee MG, Pagar VV, Kim HJ, Garcia BA, Petersson EJ, Mathis CA, Kotzbauer P, Perlmutter JS, Mach RH, Tu Z Discovery of N-(6-Methoxypyridin-3-yl)quinoline-2-amine Derivatives for Imaging Aggregated α-Synuclein in Parkinson's Disease with Positron Emission Tomography , Cells, 14(1108): 2025


Burström V, Xu K, Garro-Martínez E, Mach RH, Sahlholm K, Nibal Betari N A Nanoluciferase Complementation-based Assay for Monitoring β-arrestin2 Recruitment to the Dopamine D3 Receptor , Biochemistry and Biophysics Reports, 42(102019): 2025


Tian GL, Hsieh CJ, Guarino DS, Graham TJA, Lengyel-Zhand Z, Schmitz A, Chia WK, Young AJ, Crosby JG, Plakas K, Huang T, Jiang H, Yu Y, Hou C, Lee H, Petersson EJ, Giannakoulias S, O'Shea J, Kotzbauer P, Tu Z, Mathis CA, Mach RH The Development of a PET Radiotracer for Imaging Alpha Synuclein Aggregates in Parkinson’s Disease , RSC Med Chem , 10(1039): 2025


Li S, Schmitz A, Lu YT, Pal R, Sarkar S, Sellmyer MA, Mach RH, Lee H Evaluation of a Simplified Radiolabeling Method for a PARP Inhibitor in an Animal Model of Breast Cancer , EJNMMI Research , 15(50): 2025


Stehouwer JS, Huang G, Saturnino Guarino D, Debnath ML, Polu A, Geib SJ, Lopresti B, Ikonomovic MD, Mason N, Mach RH, Mathis CA Structure-Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1 H-indoles as Tauopathy Positron Emission Tomography Radiotracers , J Med. Chem, 68(6462-6492): 2025


Plakas K, Hsieh CJ, Guarino DS, Hou C, Chia WK, Young A, Schmitz A, Ho YP, Weng CC, Lee H, Li S, Graham TJA, Mach RH Toward a Small Molecule Antagonist Radioligand for Positron Emission Tomography Imaging of the Mu Opioid Receptor , ACS Chem. Neurosci, 16(1592-1603): 2025


Blizard GS, Dwivedi G, Pan YG, Hou C, Etersque JM, Said H, Chevrier A, Lavertu M, Ni H, Davis B, Tam Y, Cao Q, Mach RH, Weissman D, Alameh MG, Sellmyer MA. Monitoring mRNA vaccine antigen expression in vivo using PET/CT , Nature Communications, 16(1):2234: 2025


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