Robert H. Mach, PhD
Penn Medicine Provider
About me
- Britton Chance Professor of Radiology
Spoken languages
English
English
Insurance accepted
Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.
Dr. Mach is a Penn Medicine physician.
Qualifications and experience
- Academy of Molecular Imaging, National
- American Association for Cancer Research, National
- American Chemical Society, National
- Divisions of Medicinal Chemistry, Organic Chemistry, and Fluorine Chemistry, National
- Neural Basis of Psychopathology, Addictions, and Sleep Disorders, National
- New York Academy of Sciences, Local
- Society for Neuroscience, National
- Society of Molecular Imaging, National
- Society of Nuclear Medicine, National
- Society of Nuclear Medicine and Molecular Imaging, National
- Society of Radiopharmaceutical Sciences, National
- Society of Radiopharmaceutical Sciences, International
- World Molecular Imaging Society, International
Treatments and conditions
Research
Publications
Li EJ, Wiers CE, Hsieh CJ, Lee H, Schmitz A, Young AJ, Pond T, Chang J, Schubert EK, Mach RH, Kranzler HR, Dubroff JG. Total-body [(11)C]carfentanil PET: Liver-brain axis in methadone vs. buprenorphine treatment , Eur J Nucl Med Mol Imaging: 2026
Tian GL, Hsieh CJ, Saturnino Guarino D, Lengyel-Zhand Z, Chia WK, Li S, Graham TJA, Hou C, Lee H, Young AJ, Petersson EJ, Mach RH. A Structure-Activity Relationship Study of Alpha Synuclein PET Radiotracer M503-1619 , Molecules, 31: 2026,2513
Li X, Perez RM, Tu Z, Mach RH, Giannakoulias S, Petersson EJ. Machine learning prediction of multiple distinct high-affinity chemotypes for α-synuclein fibrils , Chem Commun (Camb), 62: 2026,2922-2926
Young AJ, Doot RK, Cho JK, Pham JM, Ordonez AA, Del Castillo AF, Dominguez TL, Dugyala S, Schubert EK, Lee H, Pantel AR, Mach RH, Mankoff DA, Sellmyer MA. First-in-Human Biodistribution and Dosimetry of [(11)C]Trimethoprim , Mol Imaging Biol: 2026
Weng CC, Chu CH, Khan F, Li S, Lee H, Mach RH, Hsu CH, Chung YH. Evaluating the tumour detection efficacy of [(18)F]Fluorthanatrace positron emission tomography in a metastatic lung cancer animal model , Nucl Med Biol: 2026
Zhu Y, McManus MJ, Mach RH. Novel Non-Invasive PET Imaging of Reactive Oxygen Species Using [18 F]ROStrace in Three Proteinopathy-Associated Neurodegenerative Mouse Models , Acad Radiol: 2026
Varlow C, Pees A, Stehouwer JS, Grotegerd AK, Bleher D, Guarino DS, Lindberg A, Tong J, Lopresti BJ, Knight AC, Zabrocki M, Nasser A, Shalgunov V, Ferri E, Cannazza G, McQuade P, Mathis CA, Mach RH, Battisti UM, Herfert K, Herth MM, Knudsen GM, Vasdev N. Autoradiography and preclinical PET studies with radiolabeled asyn-44 and ACI-12589 for imaging α-synuclein , J Parkinsons Dis: 2026
Stehouwer JS, Huang G, Saturnino Guarino D, Debnath ML, Polu A, Geib SJ, Lopresti B, Ikonomovic MD, Mason N, Mach RH, Mathis CA Structure-Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1 H-indoles as Tauopathy Positron Emission Tomography Radiotracers , Journal of Medicinal Chemistry, Vol 68/Issue 6: 2025 ,6462-6492
Dubroff JG, Hsieh CJ, Wiers CE, Lee H, Li EJ, Schubert EK, Mach RH, Kranzler HR [11C]Carfentanil PET Whole-Body Imaging of Mu-Opioid Receptors: A First In-Human Study , J. Nucl. Med, 66(1112-1118): 2025,1112-1118
Zhao H, Huang T, Dhavale DD, O’Shea JY, Lengyel-Zhand Z, Saturnino Guarino D, Gu J, Yue X, Nai Y-H, Jiang H, Lougee MG, Pagar VV, Kim HJ, Garcia BA, Petersson EJ, Mathis CA, Kotzbauer P, Perlmutter JS, Mach RH, Tu Z Discovery of N-(6-Methoxypyridin-3-yl)quinoline-2-amine Derivatives for Imaging Aggregated α-Synuclein in Parkinson's Disease with Positron Emission Tomography , Cells, 14(1108): 2025