About me
- Associate Professor of Otorhinolaryngology: Head and Neck Surgery
My Locations
Qualifications and experience
- American Physiological Society, National
- American Society for Biochemistry and Molecular Biology, National
- Association for Chemoreception Sciences, International
- Cell and Molecular Biology Graduate Group (Penn Biomedical Graduate Studies program), Local
- Cystic Fibrosis Foundation (US), National
- Department of Otorhinolaryngology pilot grant program, Local
- National Institutes of Health, Neuroscience of Interoception and Chemosensation (NIC) study section, National
- Penn Diabetes Research Center Pilot Grant Program, Local
- Pharmacology Graduate Group, University of Pennsylvania, Local
- Polish-U.S. Fulbright Commission, International
- The Salt and Water Club, National
- UK Medical Research Council, International
- UPenn University Research Foundation (URF), Local
- W. Garfield Weston Foundation (Canada), International
Treatments and Conditions
My research
Lee, RJ., and Cohen NA Innate immune function in chronic rhinosinusitis , Journal of Allergy and Clinical Immunology, 155: 2025,1472-1474
Kouakou YI, Thompson JC, Tan LH, Miller ZA, Ma RZ, Adappa ND, Palmer JN, Cohen NA, and <b>Lee RJ</b> Hops bitter beta-acids have antibacterial effects against sinonasal <i>Staphylococcus aureus</i> but also induce sinonasal cilia and mitochondrial dysfunction , International Forum of Allergy and Rhinology, 15: 2025,287-302
Miller ZA, Mueller A, Kim TB, Jolivert JF, Ma RZ, Muthuswami S, Park A, McMahon DB, Nead KT, Carey RM, <b>Lee RJ</b>. Lidocaine Induces Apoptosis in Head and Neck Squamous Carcinoma Cells Through Activation of Bitter Taste Receptor T2R14 , Cell Reports: 2023
Kouakou YI and <b>Lee RJ</b> Interkingdom detection of bacterial quorum sensing molecules by mammalian taste receptors , Microorganisms, 11(5): 2023,1295
Carey RM, Adappa ND, Palmer JN, <b>Lee RJ</b> Loss of CFTR Function Is Associated With Reduced Bitter Taste Receptor-Stimulated Nitric Oxide Innate Immune Responses in Nasal Epithelial Cells and Macrophages , Frontiers in Immunology, 14: 2023,1096242
Carey RM, McMahon DB, Miller ZA, Kim TB, Rajasekaran K, Gopallawa I, Newman JG, Basu D, Nead KT, White EA, <b>Lee RJ</b> T2R Bitter Taste Receptors Regulate Apoptosis and May Be Associated with Survival in Head and Neck Squamous Cell Carcinoma , Molecular Oncology, 16(7): 2022,1474-1492
McMahon DB, Kuek LE, Johnson ME, Johnson PO, Horn RLJ, Carey RM, Adappa ND, Palmer JN, and <b>Lee RJ</b> The Bitter End: T2R Bitter Receptor Agonists Elevate Nuclear Calcium and Induce Apoptosis in Non-Ciliated Airway Epithelial Cells , Cell Calcium, 101: 2022,102499
McMahon DB, Carey RM, Kohanski MA, Adappa ND, Palmer JN, and <b>Lee RJ</b> PAR-2-activated secretion by airway gland serous cells: role for CFTR and inhibition by <i>Pseudomonas aeruginosa</i> , American Journal of Physiology-Lung Cellular and Molecular Physiology, 320(5): 2021,L845-L879
Gopallawa I, Freund JR, and <b>Lee RJ</b> Bitter Taste Receptors Stimulate Phagocytosis in Human Macrophages Through Calcium, Nitric Oxide, and Cyclic-GMP Signaling , Cellular and Molecular Life Sciences, 78(1): 2021,271-286
Kuek L, and <b>Lee RJ</b> First Contact: The Role of Respiratory Cilia in Host-Pathogen Interactions in the Airways , American Journal of Physiology-Lung Cellular and Molecular Physiology, 319(4): 2020,L603-L619