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Zissimos Mourelatos, MD

Zissimos Mourelatos, MD Physician

Director, Neuropathology Professor of Pathology and Laboratory Medicine

Dr. Mourelatos is a Penn Medicine employed physician.

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About Dr. Zissimos Mourelatos

Received the Penn Medicine Award of Excellence, 2006

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Anatomic and Clinical Pathology, 1999

Description of Clinical Expertise

Surgical Neuropathology (Brain tumors; Brain biopsies; Muscle biopsies; Nerve biopsies)
Medical Neuropathology

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Aristotelian University of Thessaloniki
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


Ad Hoc Member, Grant Reviews, Netherlands Organization for Health Research and Development, The Netherlands, International Ad Hoc Member, Grant reviews, Wellcome Trust, London, UK, International Ad Hoc Member, MGB Study Section CSR/NIH , National Ad Hoc Member, NCF Study Section CSR/NIH, National Ad Hoc Member, ZCA1 GRB-S P01 Study Section, NCI/NIH, National Ad Hoc Member, ZMH1 ERB-L Study Section, CSR/NIH/NIMH, National Ad Hoc Member, ZRG1 Study Section, CSR/NIH/NINDS, National American Association for the Advancement in Science, National American Association of Neuropathologists, National Human Frontier Science Program (HFSP), International Member, Grant Reviews, European Union Commission on Framework Grants; Brussels, EU, International Permanent Member, MGB Study Section CSR/NIH , National Reviewer, Agence Nationale de la Recerche, France (ANR), International Reviewer, Austrian Science Fund, Vienna, Austria, International Reviewer, Hellenic Ministry of Education Research Council, Athens, Greece, International Reviewer, Israel Science Foundation, International Reviewer, Swedish Research Council, International

Hospital Affiliation

Dr. Mourelatos is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Biochemical and genetic studies of Ribonucleoproteins (RNPs) with emphasis on
small regulatory RNPs such as microRNAs (miRNAs) and piRNAs (Piwi-associated RNAs).
Biochemical and genetic studies of mRNA translation and mRNA decay.
Biochemical and genetic studies of RNA dysregulation in the pathogenesis of neurodegeneration.

Selected Publications:

Couthouis J., Hart M.P., Erion R., King O.D., Diaz Z., Nakaya T., Ibrahim F., Kim H.J., Mojsilovic-Petrovic J., Panossian S., Kim C.E., Frackelton E.C., Solski J.A., Williams K.L., Clay-Falcone D., Elman L., McCluskey L., Greene R., Hakonarson H., Kalb R.G., Lee V-MY, Trojanowski J.Q., Nicholson G.A., Blair I.P., Bonini N.M., Van Deerlin V.M., Mourelatos Z. ,Shorter J and A.D. Gitler: Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis Human Molecular Genetics 21 : 2899-911,2012.

Liu X., Jin D-Y, McManus M.T. and Z. Mourelatos: Precursor MicroRNA-Programmed Silencing Complex Assembly Pathways in Mammals Molecular Cell 46 : 507-17,2012.

Vourekas, A, Zheng Q., Kirino Y., Alexiou P., Maragkakis, M., Gregory B.D. and Z. Mourelatos : Target RNA repertoire of Mili and Miwi reveals piRNA biogenesis and function of Miwi in spermiogenesis Nature Structural & Molecular Biology 19 : 773-81,2012.

Venneti S, Moss HE, Levin MH, Vagefi MR, Brozena CS, Pruitt AA, Mourelatos Z, Trojanowski JQ, Galetta SL, Balcer LJ: Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity Journal of the Neurological Sciences 301 (1-2): 112-5,2011.

Couthouis J., Erion R., Hart M.P., Oristano R.E., Liu X.A., Ramos D., Jethava N., Hosangadi D., Epstein J., Chiang A., Diaz Z., Nakaya T., Ibrahim F., King O.D., , Kim H.J., Panossian S., Kim C.E., Frackelton E.C., Geser F., Clay-Falcone D., Elman L., McCluskey L., Greene R., Lee V-MY, Trojanowski J.Q., Hakonarson H., Bonini N.M., Shorter J., Van Deerlin V.M., Mourelatos Z. and A.D. Gitler: A yeast functional screen predicts new candidate ALS disease genes. PNAS 108 : 20881-90,2011.

Venneti S., Boateng L.A., Friedman J.R, Baldwin D.A., Tobias J.W., Judkins A.R., Mourelatos Z. and L. Priti.: MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. Brain Pathology 22 (4): 522-9,2012.

Kirino Y, Vourekas A, Khandros E, Mourelatos Z: Immunoprecipitation of piRNPs and directional, next generation sequencing of piRNAs Methods Molecular Biology 725 : 281-93,2011.

de Planell-Saguer M, Rodicio MC, Mourelatos Z: Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment Nature Protocols 5 (6): 1061-73,2010.

Kirino Y, Vourekas A, Kim N, de Lima Alves F, Rappsilber J, Klein PS, Jongens TA, Mourelatos Z: Arginine methylation of vasa protein is conserved across phyla J Biol Chem 285 (11): 8148-54,2010.

Kirino A, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, and Mourelatos Z : Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization RNA 16 (1): 70-8,2010.

View all publications

Academic Contact Info

Department of Pathology and Laboratory Medicine
Division of Neuropathology
613B Stellar Chance Labs
422 Curie Boulevard

Philadelphia, PA 19104-6100
Phone: 215-746-0014
Fax: 215-746-0285
Patient appointments: 800-789-7366 (PENN)

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