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My research focuses on deciphering the key molecular mechanism that regulates vessel formation and tissue repair. My lab uses a multidisciplinary approach combining cell and molecular biology, genetics, and animal models to investigate: 1. The molecular mechanisms by which proteases regulate stem cell function during tissue repair and regeneration; 2. The regulatory mechanism underlying new vessel formation in normal development and disease; 3 Endothelial plasticity in ischemic microenvironment that leads to the abnormal neovascularization in ischemic heart disease.
Wang Q, He Z, Huang M, Liu T, Xu H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O’Rourke DM, Dahmane N, Brem S, Gong Y, & Fan Y: Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α Nature Comm. 9 (559): 2018.
Wang Y, Xu H, Liu T, Huang M, Butter P, Li C, Zhang L, Kao G, Gong Y, Maity A, Koumenis C, & Fan Y: Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells. JCI Insight. 3 (3): e98096,2018.
Tao L., Yang J., Cao F., Xie H., Zhang M., Gong Y.*, Zhang C.*: Mogroside IIIE, A novel anti-fibrotic compound, reduces pulmonary fibrosis through Toll like receptor 4 pathways. J Pharmacol. Exp. Ther. 361 (2): 2017 *co-senior author.
Huang M., Liu T., Ma P., Mitteer A., Cai, P., Li C., Zhang L., Zhao B., Gong Y. Koumenis, C., Fan Y: c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J. Clin. Invest. 126 (5) : 1801-14,2016.
Gong Y*, Zhao Y, Li Y, Fan Y, Hoover-Plow J: Plasminogen regulates cardiac repair after myocardial infarction through its noncanonical function in stem cell homing to the infarcted heart. J Am Coll Cardiol 63 (25): 2862-2872,2014 *Corresponding author.
Huang M, Gong Y, Grondosky J, Hoover-Plow J: Lp(a)/apo(a) modulate MMP-9 activation and neutrophil cytokines in vivo in inflammation to regulate leukocyte recruitment. Am J Pathol 184 (5): 1503-1507,2014.
Fan Y, Potdar AA, Gong Y, Eswarappa SM, Donnola S, Lathia JD, Hambardzumyan D, Rich JN, Fox PL: Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation. Nat Cell Biol 16 (5): 445-456,2014.
Fan Y, Arif A, Gong Y, Jia J, Eswarappa SM, Willard B, Horowitz A, Graham LM, Penn MS, Fox PL.: Stimulus-dependent phosphorylation of profilin-1 in angiogenesis.
Nat Cell Biol 14 (10): 1046-56,2012.
Gong Y*, Fan Y, Hoover-Plow J: Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9.
Arterioscler Thromb Vasc Biol 31 (9): 2035-43,2011 *Corresponding author.
Gong Y, Hart E, Shchurin A, Hoover-Plow J: Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice.
J Clin Invest 118 (9): 3012-24,2008.
Perelman School of Medicine at The University of PennsylvaniaDivision of Translational Medicine and Human GeneticsSmilow Center for Translational Research, Room 11-142 3400 Civic Center Blvd.Philadelphia, PA 19104